(86 nodes) (2023) TGFbeta inhibition and mesenchymal to epithelial transition initiation by Xenopus egg extract: first steps towards early reprogramming in fish somatic cell. network (Sinocyclocheilus grahami)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000025383	Fibronectin-like. (2463 aa)
	SMAD9-2	SMAD family member 9. (468 aa)
	LOC107562073	Keratin, type I cytoskeletal 50 kDa-like. (473 aa)
	LOC107553040	Claudin-4-like. (215 aa)
	LOC107557698	Plakophilin-3-like. (734 aa)
	LOC107549121	Acetyl-CoA acetyltransferase, cytosolic-like. (395 aa)
	LOC107560966	Kremen protein 1-like isoform X1. (462 aa)
	LOC107601616	Secreted frizzled-related protein 3-like. (319 aa)
	Sfrp2	Secreted frizzled-related protein 2. (308 aa)
	LOC107600624	R-spondin-2-like. (248 aa)
	LOC107601571	Noggin-1-like. (217 aa)
	LOC107583766	Mothers against decapentaplegic homolog 6-like. (487 aa)
	ENSSGRP00000049214	Tight junction protein ZO-1-like isoform X1. (1752 aa)
	ENSSGRP00000048284	Dickkopf-related protein 1-like. (243 aa)
	LOC107584374	BMP and activin membrane-bound inhibitor homolog. (261 aa)
	LOC107589597	Left-right determination factor 2-like. (362 aa)
	SMAD9	Mothers against decapentaplegic homolog 9-like isoform X1. (434 aa)
	ENSSGRP00000042971	Fatty acid synthase. (1820 aa)
	LOC107556646	Noggin-2. (211 aa)
	ENSSGRP00000039366	Proto-oncogene tyrosine-protein kinase Src-like isoform X1. (505 aa)
	LOC107600514	R-spondin 3. (316 aa)
	LOC107559859	Acetyl-coenzyme A synthetase, cytoplasmic-like isoform X1. (698 aa)
	LOC107568024	Lanosterol 14-alpha demethylase. (503 aa)
	notum	Palmitoleoyl-protein carboxylesterase NOTUM. (505 aa)
	LOC107584736	7-dehydrocholesterol reductase. (457 aa)
	ENSSGRP00000029007	E3 ubiquitin-protein ligase SMURF2-like. (359 aa)
	fasn	Fatty acid synthase, animal type. (2525 aa)
	FZD10	Frizzled-10-B-like. (580 aa)
	LOC107574881	Protein sprouty homolog 1-like. (298 aa)
	hmgcs1	Hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1. (580 aa)
	LOC107551185	R-spondin-2-like. (247 aa)
	LOC107548349	Methylsterol monooxygenase 1-like. (291 aa)
	LOC107552167	Claudin-4-like. (215 aa)
	Lef1	Lymphoid enhancer-binding factor 1. (343 aa)
	LOC107594997	Secreted frizzled-related protein 1-like. (306 aa)
	LOC107560256	Homeobox protein SAX-1-like. (359 aa)
	LOC107574503	Gremlin-2-like. (166 aa)
	LOC107552770	Sclerostin-like. (211 aa)
	LOC107552760	Zinc finger E-box-binding homeobox 1-like isoform X1. (1096 aa)
	LOC107552099	Palmitoleoyl-protein carboxylesterase notum1a-like. (478 aa)
	LOC107601365	Secreted frizzled-related protein 3-like. (159 aa)
	LOC107594427	Lymphoid enhancer-binding factor 1-like. (371 aa)
	ENSSGRP00000010302	ATP citrate (pro-S)-lyase. (1075 aa)
	fdft1	Farnesyl-diphosphate farnesyltransferase. (451 aa)
	smad6	Mothers against decapentaplegic homolog 6. (450 aa)
	LOC107549411	BMP and activin membrane-bound inhibitor homolog. (261 aa)
	LOC107587465	Secreted frizzled-related protein 1-like. (306 aa)
	ENSSGRP00000000202	Kremen protein 1-like. (460 aa)
	ENSSGRP00000112989	Protocadherin delta 2. (1172 aa)
	LOC107590469	Proto-oncogene tyrosine-protein kinase Src isoform X1. (553 aa)
	smurf2	E3 ubiquitin-protein ligase SMURF2 isoform X1. (765 aa)
	ENSSGRP00000109630	Homeobox protein Hox-B5b-like. (202 aa)
	LOC107596967	Mothers against decapentaplegic homolog 6-like. (488 aa)
	LOC107563552	Keratin, type I cytoskeletal 50 kDa-like. (462 aa)
	LOC107574886	Dual specificity protein phosphatase 6-like. (382 aa)
	ENSSGRP00000101582	Solute carrier family 25 (mitochondrial citrate transporter), member 1. (295 aa)
	LOC107591587	Methylsterol monooxygenase 1. (291 aa)
	LOC107550477	Matrix metalloproteinase-9 (gelatinase B). (678 aa)
	ENSSGRP00000099127	Collagen alpha-1(I) chain-like isoform X1. (1359 aa)
	LOC107586666	Left-right determination factor 2-like. (362 aa)
	ENSSGRP00000094572	Connexin 43. (282 aa)
	ENSSGRP00000094346	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b. (162 aa)
	LOC107556289	Fibronectin-like isoform X1. (2495 aa)
	ENSSGRP00000092732	Sterol regulatory element binding transcription factor 1. (1034 aa)
	LOC107567706	ATP citrate (pro-S)-lyase. (1114 aa)
	ENSSGRP00000087246	Cadherin-24-like. (788 aa)
	ENSSGRP00000086962	Transcription factor 7-like 2. (362 aa)
	LOC107554676	Protocadherin-12-like isoform X1. (1176 aa)
	LOC107551550	Acetyl-coenzyme A synthetase, cytoplasmic-like isoform X1. (698 aa)
	LOC107572944	Dual specificity protein phosphatase 6-like. (382 aa)
	ENSSGRP00000082393	Gremlin 2, DAN family BMP antagonist a. (151 aa)
	LOC107582755	Zinc finger E-box-binding homeobox 1-like. (1090 aa)
	LOC107601581	Acetyl-CoA acetyltransferase, cytosolic-like. (395 aa)
	LOC107582741	Sclerostin-like. (213 aa)
	ENSSGRP00000079598	Transcription factor 7. (380 aa)
	ENSSGRP00000078178	Dickkopf-related protein 1-like. (244 aa)
	ENSSGRP00000077692	Tight junction protein 1a. (1634 aa)
	LOC107583498	Gremlin-2-like. (194 aa)
	LOC107555113	Frizzled-10-A-like. (580 aa)
	ENSSGRP00000071057	Low-density lipoprotein receptor-related protein 5-like. (1602 aa)
	ENSSGRP00000070226	Mothers against decapentaplegic homolog 6-like isoform X1. (454 aa)
	LOC107553058	Plakophilin-3-like. (781 aa)
	LOC107570400	Gremlin-2-like. (166 aa)
	LOC107591829	Matrix metalloproteinase-9 (gelatinase B). (689 aa)
	srebf1	Sterol regulatory element-binding transcription factor 1. (1134 aa)
	ENSSGRP00000064974	Noggin-2-like. (211 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000000202	ENSSGRP00000048284	ENSSGRP00000000202	ENSSGRP00000048284	Kremen protein 1-like.	Dickkopf-related protein 1-like.	0.894
ENSSGRP00000000202	ENSSGRP00000071057	ENSSGRP00000000202	ENSSGRP00000071057	Kremen protein 1-like.	Low-density lipoprotein receptor-related protein 5-like.	0.877
ENSSGRP00000000202	ENSSGRP00000078178	ENSSGRP00000000202	ENSSGRP00000078178	Kremen protein 1-like.	Dickkopf-related protein 1-like.	0.894
ENSSGRP00000010302	ENSSGRP00000042971	ENSSGRP00000010302	ENSSGRP00000042971	ATP citrate (pro-S)-lyase.	Fatty acid synthase.	0.762
ENSSGRP00000010302	ENSSGRP00000101582	ENSSGRP00000010302	ENSSGRP00000101582	ATP citrate (pro-S)-lyase.	Solute carrier family 25 (mitochondrial citrate transporter), member 1.	0.531
ENSSGRP00000010302	LOC107549121	ENSSGRP00000010302	ENSSGRP00000055695	ATP citrate (pro-S)-lyase.	Acetyl-CoA acetyltransferase, cytosolic-like.	0.869
ENSSGRP00000010302	LOC107551550	ENSSGRP00000010302	ENSSGRP00000085248	ATP citrate (pro-S)-lyase.	Acetyl-coenzyme A synthetase, cytoplasmic-like isoform X1.	0.436
ENSSGRP00000010302	LOC107559859	ENSSGRP00000010302	ENSSGRP00000039067	ATP citrate (pro-S)-lyase.	Acetyl-coenzyme A synthetase, cytoplasmic-like isoform X1.	0.436
ENSSGRP00000010302	LOC107567706	ENSSGRP00000010302	ENSSGRP00000092478	ATP citrate (pro-S)-lyase.	ATP citrate (pro-S)-lyase.	0.900
ENSSGRP00000010302	LOC107601581	ENSSGRP00000010302	ENSSGRP00000080225	ATP citrate (pro-S)-lyase.	Acetyl-CoA acetyltransferase, cytosolic-like.	0.869
ENSSGRP00000010302	fasn	ENSSGRP00000010302	ENSSGRP00000028429	ATP citrate (pro-S)-lyase.	Fatty acid synthase, animal type.	0.950
ENSSGRP00000010302	hmgcs1	ENSSGRP00000010302	ENSSGRP00000058761	ATP citrate (pro-S)-lyase.	Hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1.	0.898
ENSSGRP00000025383	LOC107556289	ENSSGRP00000025383	ENSSGRP00000093589	Fibronectin-like.	Fibronectin-like isoform X1.	0.900
ENSSGRP00000029007	ENSSGRP00000070226	ENSSGRP00000029007	ENSSGRP00000070226	E3 ubiquitin-protein ligase SMURF2-like.	Mothers against decapentaplegic homolog 6-like isoform X1.	0.939
ENSSGRP00000029007	ENSSGRP00000094572	ENSSGRP00000029007	ENSSGRP00000094572	E3 ubiquitin-protein ligase SMURF2-like.	Connexin 43.	0.426
ENSSGRP00000029007	LOC107583766	ENSSGRP00000029007	ENSSGRP00000049337	E3 ubiquitin-protein ligase SMURF2-like.	Mothers against decapentaplegic homolog 6-like.	0.938
ENSSGRP00000029007	LOC107596967	ENSSGRP00000029007	ENSSGRP00000108175	E3 ubiquitin-protein ligase SMURF2-like.	Mothers against decapentaplegic homolog 6-like.	0.938
ENSSGRP00000029007	SMAD9	ENSSGRP00000029007	ENSSGRP00000044683	E3 ubiquitin-protein ligase SMURF2-like.	Mothers against decapentaplegic homolog 9-like isoform X1.	0.697
ENSSGRP00000029007	SMAD9-2	ENSSGRP00000029007	ENSSGRP00000058417	E3 ubiquitin-protein ligase SMURF2-like.	SMAD family member 9.	0.697
ENSSGRP00000029007	smad6	ENSSGRP00000029007	ENSSGRP00000004658	E3 ubiquitin-protein ligase SMURF2-like.	Mothers against decapentaplegic homolog 6.	0.939