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Tint_1132 Tint_1132 leuA leuA ilvD ilvD ilvD-2 ilvD-2 Tint_2113 Tint_2113 ilvC ilvC Tint_2153 Tint_2153 Tint_2154 Tint_2154 leuB leuB leuD leuD leuC leuC ilvE ilvE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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Your Input:
Tint_1132TIGRFAM: tartrate dehydrogenase; KEGG: vei:Veis_2698 tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (367 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (570 aa)
ilvDTIGRFAM: dihydroxy-acid dehydratase; KEGG: pol:Bpro_2052 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (561 aa)
ilvD-2TIGRFAM: dihydroxy-acid dehydratase; KEGG: aeh:Mlg_0418 dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (613 aa)
Tint_2113PFAM: aminotransferase class I and II; KEGG: mpt:Mpe_A1540 aminotransferase AlaT. (410 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
Tint_2153KEGG: dac:Daci_4866 acetolactate synthase 3 regulatory subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (163 aa)
Tint_2154KEGG: lch:Lcho_2893 acetolactate synthase 3 catalytic subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. (596 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (215 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (311 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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