node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tint_0335 | Tint_0943 | Tint_0335 | Tint_0943 | PFAM: acylphosphatase; KEGG: hha:Hhal_0703 acylphosphatase. | PFAM: AMP-dependent synthetase and ligase; KEGG: app:CAP2UW1_2247 AMP-dependent synthetase and ligase. | 0.900 |
Tint_0335 | Tint_1147 | Tint_0335 | Tint_1147 | PFAM: acylphosphatase; KEGG: hha:Hhal_0703 acylphosphatase. | Phosphate acetyltransferase; KEGG: rpd:RPD_1127 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase. | 0.923 |
Tint_0335 | ackA | Tint_0335 | Tint_1146 | PFAM: acylphosphatase; KEGG: hha:Hhal_0703 acylphosphatase. | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.913 |
Tint_0335 | acsA | Tint_0335 | Tint_2070 | PFAM: acylphosphatase; KEGG: hha:Hhal_0703 acylphosphatase. | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.900 |
Tint_0474 | Tint_0732 | Tint_0474 | Tint_0732 | 2-hydroxy-3-oxopropionate reductase; KEGG: lch:Lcho_1636 6-phosphogluconate dehydrogenase NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. | KEGG: mpt:Mpe_A3524 methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. | 0.928 |
Tint_0474 | Tint_0943 | Tint_0474 | Tint_0943 | 2-hydroxy-3-oxopropionate reductase; KEGG: lch:Lcho_1636 6-phosphogluconate dehydrogenase NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. | PFAM: AMP-dependent synthetase and ligase; KEGG: app:CAP2UW1_2247 AMP-dependent synthetase and ligase. | 0.803 |
Tint_0474 | Tint_1147 | Tint_0474 | Tint_1147 | 2-hydroxy-3-oxopropionate reductase; KEGG: lch:Lcho_1636 6-phosphogluconate dehydrogenase NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. | Phosphate acetyltransferase; KEGG: rpd:RPD_1127 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase. | 0.800 |
Tint_0474 | Tint_1874 | Tint_0474 | Tint_1874 | 2-hydroxy-3-oxopropionate reductase; KEGG: lch:Lcho_1636 6-phosphogluconate dehydrogenase NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. | PFAM: aminotransferase class-III; KEGG: bte:BTH_I1505 omega amino acid--pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.900 |
Tint_0474 | Tint_2302 | Tint_0474 | Tint_2302 | 2-hydroxy-3-oxopropionate reductase; KEGG: lch:Lcho_1636 6-phosphogluconate dehydrogenase NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. | propionate/CoA ligase; KEGG: rpi:Rpic_2037 propionyl-CoA synthetase; TIGRFAM: propionate/CoA ligase; PFAM: AMP-dependent synthetase and ligase. | 0.803 |
Tint_0474 | Tint_2303 | Tint_0474 | Tint_2303 | 2-hydroxy-3-oxopropionate reductase; KEGG: lch:Lcho_1636 6-phosphogluconate dehydrogenase NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. | Hypothetical protein; KEGG: pol:Bpro_2634 zinc-binding alcohol dehydrogenase; TIGRFAM: quinone oxidoreductase, YhdH/YhfP family; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein. | 0.828 |
Tint_0474 | acsA | Tint_0474 | Tint_2070 | 2-hydroxy-3-oxopropionate reductase; KEGG: lch:Lcho_1636 6-phosphogluconate dehydrogenase NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.803 |
Tint_0732 | Tint_0474 | Tint_0732 | Tint_0474 | KEGG: mpt:Mpe_A3524 methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. | 2-hydroxy-3-oxopropionate reductase; KEGG: lch:Lcho_1636 6-phosphogluconate dehydrogenase NAD-binding; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. | 0.928 |
Tint_0732 | Tint_0943 | Tint_0732 | Tint_0943 | KEGG: mpt:Mpe_A3524 methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. | PFAM: AMP-dependent synthetase and ligase; KEGG: app:CAP2UW1_2247 AMP-dependent synthetase and ligase. | 0.934 |
Tint_0732 | Tint_1147 | Tint_0732 | Tint_1147 | KEGG: mpt:Mpe_A3524 methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. | Phosphate acetyltransferase; KEGG: rpd:RPD_1127 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase. | 0.929 |
Tint_0732 | Tint_1874 | Tint_0732 | Tint_1874 | KEGG: mpt:Mpe_A3524 methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. | PFAM: aminotransferase class-III; KEGG: bte:BTH_I1505 omega amino acid--pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.934 |
Tint_0732 | Tint_2302 | Tint_0732 | Tint_2302 | KEGG: mpt:Mpe_A3524 methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. | propionate/CoA ligase; KEGG: rpi:Rpic_2037 propionyl-CoA synthetase; TIGRFAM: propionate/CoA ligase; PFAM: AMP-dependent synthetase and ligase. | 0.934 |
Tint_0732 | Tint_2303 | Tint_0732 | Tint_2303 | KEGG: mpt:Mpe_A3524 methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. | Hypothetical protein; KEGG: pol:Bpro_2634 zinc-binding alcohol dehydrogenase; TIGRFAM: quinone oxidoreductase, YhdH/YhfP family; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein. | 0.910 |
Tint_0732 | Tint_2370 | Tint_0732 | Tint_2370 | KEGG: mpt:Mpe_A3524 methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.907 |
Tint_0732 | Tint_2371 | Tint_0732 | Tint_2371 | KEGG: mpt:Mpe_A3524 methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.910 |
Tint_0732 | accA | Tint_0732 | Tint_0425 | KEGG: mpt:Mpe_A3524 methylmalonate-semialdehyde dehydrogenase [acylating]; TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase. | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. | 0.900 |