STRINGSTRING
rph rph recD recD recB recB recC recC Tint_2438 Tint_2438 Tint_1063 Tint_1063 orn orn Tint_0892 Tint_0892 Tint_0439 Tint_0439 Tint_0389 Tint_0389 Tint_0002 Tint_0002 Tint_3068 Tint_3068 Tint_3017 Tint_3017 Tint_3015 Tint_3015 Tint_2944 Tint_2944 Tint_2923 Tint_2923 Tint_2922 Tint_2922 Tint_2666 Tint_2666 Tint_2201 Tint_2201 Tint_2009 Tint_2009 Tint_1979 Tint_1979 dnaE2 dnaE2 rnr rnr xseA xseA xseB xseB Tint_1439 Tint_1439 Tint_1423 Tint_1423 Tint_1404 Tint_1404 dnaQ dnaQ Tint_1326 Tint_1326 polA polA Tint_1117 Tint_1117
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (243 aa)
recDExodeoxyribonuclease V, alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (691 aa)
recBExodeoxyribonuclease V, beta subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (1202 aa)
recCExodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (1173 aa)
Tint_2438DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: bte:BTH_I0984 DNA polymerase III subunit alpha; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type. (1146 aa)
Tint_1063DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; TIGRFAM: DNA polymerase III, epsilon subunit; KEGG: rfr:Rfer_2572 DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein. (469 aa)
ornExonuclease RNase T and DNA polymerase III; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (203 aa)
Tint_0892single-stranded-DNA-specific exonuclease RecJ; KEGG: cti:RALTA_A1151 ssDNA exonuclease, 5'--> 3'-specific, Mg-dependent; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1. (574 aa)
Tint_0439PFAM: RNA-metabolising metallo-beta-lactamase; KEGG: afr:AFE_2679 metallo-beta-lactamase family protein. (460 aa)
Tint_0389KEGG: ajs:Ajs_4192 TrwC protein; TIGRFAM: conjugative relaxase domain protein; PFAM: TrwC relaxase. (945 aa)
Tint_0002DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (371 aa)
Tint_3068KEGG: ppr:PBPRB1139 hypothetical protein. (173 aa)
Tint_3017PFAM: Integrase catalytic region; KEGG: vap:Vapar_2113 integrase catalytic region. (493 aa)
Tint_3015KEGG: tmz:Tmz1t_4040 hypothetical protein. (394 aa)
Tint_2944PFAM: protein of unknown function DUF1631; KEGG: mpt:Mpe_A0847 hypothetical protein. (790 aa)
Tint_2923Phage-type endonuclease; KEGG: dar:Daro_1657 hypothetical protein; TIGRFAM: phage-type endonuclease; PFAM: YqaJ viral recombinase family. (328 aa)
Tint_2922KEGG: har:HEAR0513 putative hydrolase or metal-binding protein. (313 aa)
Tint_2666PFAM: domain of unknown function DUF1732; YicC domain protein; KEGG: ctt:CtCNB1_3789 hypothetical protein. (292 aa)
Tint_2201DNA topoisomerase; KEGG: rbi:RB2501_04285 hypothetical protein; PFAM: Relaxase/mobilization nuclease family protein. (718 aa)
Tint_2009PFAM: Relaxase/mobilization nuclease family protein; KEGG: pna:Pnap_2533 relaxase/mobilization nuclease family protein. (711 aa)
Tint_1979PFAM: domain of unknown function DUF1738; KEGG: pna:Pnap_2529 hypothetical protein. (874 aa)
dnaE2DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1037 aa)
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (775 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (448 aa)
xseBExodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (88 aa)
Tint_1439PFAM: RNA-metabolising metallo-beta-lactamase; KEGG: afr:AFE_2679 metallo-beta-lactamase family protein. (460 aa)
Tint_1423KEGG: lch:Lcho_1246 exodeoxyribonuclease III Xth; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase. (253 aa)
Tint_1404PFAM: Integrase catalytic region; KEGG: vap:Vapar_2113 integrase catalytic region. (506 aa)
dnaQDNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (239 aa)
Tint_1326TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; KEGG: rme:Rmet_0149 exodeoxyribonuclease III (xth); PFAM: Endonuclease/exonuclease/phosphatase. (267 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (934 aa)
Tint_1117PFAM: RNA-metabolising metallo-beta-lactamase; KEGG: rme:Rmet_1266 beta-lactamase-like protein. (476 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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