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| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (934 aa) |
| | Tint_1409 | PFAM: transposase IS3/IS911 family protein; KEGG: reu:Reut_C5937 transposase IS3/IS911. (105 aa) |
| | Tint_1408 | PFAM: Integrase catalytic region; KEGG: reu:Reut_C5938 integrase catalytic subunit. (276 aa) |
| | Tint_1405 | KEGG: pol:Bpro_2488 cointegrate resolution protein T. (366 aa) |
| | Tint_1404 | PFAM: Integrase catalytic region; KEGG: vap:Vapar_2113 integrase catalytic region. (506 aa) |
| | Tint_1402 | PFAM: transposase Tn3 family protein; KEGG: bpt:Bpet3722 ISSod9, transposase. (739 aa) |
| | Tint_1401 | PFAM: transposase IS3/IS911 family protein; KEGG: vei:Veis_4708 transposase IS3/IS911 family protein. (80 aa) |
| | Tint_1400 | PFAM: Integrase catalytic region; KEGG: vei:Veis_4709 integrase catalytic subunit. (298 aa) |
| | Tint_1396 | PFAM: transposase IS4 family protein; KEGG: vei:Veis_3679 transposase, IS4 family protein. (478 aa) |
| | Tint_1392 | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (2005 aa) |
| | ihfA | Integration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (115 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (239 aa) |
| | Tint_1361 | Hypothetical protein; KEGG: rpf:Rpic12D_3122 integrase family protein; Belongs to the 'phage' integrase family. (229 aa) |
| | Tint_1326 | TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; KEGG: rme:Rmet_0149 exodeoxyribonuclease III (xth); PFAM: Endonuclease/exonuclease/phosphatase. (267 aa) |
| | Tint_1325 | PFAM: transposase IS4 family protein; KEGG: avn:Avin_24710 transposase, IS4. (341 aa) |
| | Tint_0298 | Transposase, IS605 OrfB family; KEGG: avn:Avin_15780 transposase, IS891/IS1136/IS1341; TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase IS891/IS1136/IS1341 family; transposase IS605 OrfB. (426 aa) |
| | Tint_0299 | PFAM: transposase IS200-family protein; KEGG: pna:Pnap_1279 transposase IS200-family protein. (138 aa) |
| | Tint_0304 | Transposase, IS605 OrfB family; KEGG: stm:STM2599 putative virulence protein; TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase IS891/IS1136/IS1341 family; transposase IS605 OrfB. (391 aa) |
| | Tint_0307 | PFAM: putative transposase IS891/IS1136/IS1341 family; transposase IS605 OrfB; KEGG: eba:p1B202 transposase. (429 aa) |
| | Tint_0330 | Transposase, IS605 OrfB family; KEGG: avn:Avin_15780 transposase, IS891/IS1136/IS1341; TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase IS891/IS1136/IS1341 family; transposase IS605 OrfB. (406 aa) |
| | Tint_0339 | KEGG: ajs:Ajs_0418 twitching motility protein; TIGRFAM: twitching motility protein; PFAM: type II secretion system protein E. (378 aa) |
| | Tint_0340 | PFAM: putative transposase IS891/IS1136/IS1341 family; transposase IS605 OrfB; KEGG: eba:p1B202 transposase. (718 aa) |
| | Tint_0341 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (388 aa) |
| | mutM | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (291 aa) |
| | Tint_0376 | KEGG: bph:Bphy_2661 NUDIX hydrolase; manually curated; PFAM: NUDIX hydrolase; Belongs to the Nudix hydrolase family. (137 aa) |
| | Tint_0383 | PFAM: integrase family protein; KEGG: tbd:Tbd_0943 putative integrase prophage protein; Belongs to the 'phage' integrase family. (407 aa) |
| | Tint_0389 | KEGG: ajs:Ajs_4192 TrwC protein; TIGRFAM: conjugative relaxase domain protein; PFAM: TrwC relaxase. (945 aa) |
| | Tint_0397 | PFAM: replication C family protein; KEGG: sty:HCM1.221 putative replication protein. (311 aa) |
| | Tint_0398 | KEGG: pna:Pnap_5005 putative DNA helicase. (299 aa) |
| | Tint_0424 | HhH-GPD family protein; KEGG: reu:Reut_A1123 HhH-GPD; PFAM: HhH-GPD family protein; SMART: HhH-GPD family protein. (221 aa) |
| | Tint_0454 | KEGG: mms:mma_2792 transposase IstA. (58 aa) |
| | parC | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (777 aa) |
| | parE | DNA topoisomerase (ATP-hydrolyzing); Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (652 aa) |
| | Tint_0485 | Protein of unknown function DUF195; KEGG: mpt:Mpe_A1514 hypothetical protein; manually curated; PFAM: protein of unknown function DUF195. (509 aa) |
| | Tint_0486 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (811 aa) |
| | Tint_0497 | Hypothetical protein; KEGG: vap:Vapar_2113 integrase catalytic region. (66 aa) |
| | Tint_0509 | PFAM: integrase family protein; KEGG: rpf:Rpic12D_2659 integrase family protein; Belongs to the 'phage' integrase family. (517 aa) |
| | Tint_0525 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (978 aa) |
| | Tint_0526 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (402 aa) |
| | Tint_0570 | PFAM: transposase IS4 family protein; KEGG: avn:Avin_24710 transposase, IS4. (341 aa) |
| | Tint_0579 | KEGG: aav:Aave_4630 sporulation domain-containing protein. (256 aa) |
| | Tint_0580 | KEGG: app:CAP2UW1_0244 biotin/acetyl-CoA-carboxylase ligase; TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; PFAM: protein of unknown function DUF559; biotin/lipoate A/B protein ligase; biotin protein ligase domain protein. (445 aa) |
| | Tint_0583 | TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; KEGG: mpt:Mpe_A0265 DNA topoisomerase III; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. (843 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (520 aa) |
| | Tint_0607 | KEGG: bcm:Bcenmc03_4071 AraC family transcriptional regulator; PFAM: Ada metal-binding domain protein; helix-turn-helix- domain containing protein AraC type; AlkA domain protein; HhH-GPD family protein; SMART: Helix-turn-helix, AraC domain; HhH-GPD family protein. (484 aa) |
| | Tint_0608 | methylated-DNA/protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (172 aa) |
| | Tint_0612 | KEGG: mmb:Mmol_1614 DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein. (415 aa) |
| | Tint_0631 | KEGG: rpe:RPE_1481 superfamily II DNA/RNA helicase. (1041 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (719 aa) |
| | Tint_0694 | KEGG: mpt:Mpe_A3104 hypothetical protein. (248 aa) |
| | recA | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa) |
| | Tint_0874 | PFAM: protein of unknown function DUF34; KEGG: har:HEAR3055 hypothetical protein. (247 aa) |
| | Tint_0892 | single-stranded-DNA-specific exonuclease RecJ; KEGG: cti:RALTA_A1151 ssDNA exonuclease, 5'--> 3'-specific, Mg-dependent; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1. (574 aa) |
| | Tint_0911 | PFAM: deoxyribodipyrimidine photolyase-related protein; KEGG: lch:Lcho_1250 deoxyribodipyrimidine photolyase-related protein. (519 aa) |
| | Tint_0955 | KEGG: lch:Lcho_2312 hypothetical protein. (162 aa) |
| | Tint_1013 | PFAM: transposase IS4 family protein; KEGG: app:CAP2UW1_4671 hypothetical protein. (451 aa) |
| | Tint_1016 | PFAM: TatD-related deoxyribonuclease; KEGG: bxe:Bxe_A1568 putative TatD-related deoxyribonuclease. (291 aa) |
| | Tint_1039 | PFAM: UvrD/REP helicase; KEGG: mpt:Mpe_A1142 ATP-dependent DNA helicase UvrD. (781 aa) |
| | Tint_1063 | DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; TIGRFAM: DNA polymerase III, epsilon subunit; KEGG: rfr:Rfer_2572 DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein. (469 aa) |
| | Tint_1079 | PFAM: Integrase catalytic region; KEGG: reu:Reut_C5938 integrase catalytic subunit. (276 aa) |
| | Tint_1080 | PFAM: transposase IS3/IS911 family protein; KEGG: reu:Reut_C5937 transposase IS3/IS911. (105 aa) |
| | Tint_1084 | Hypothetical protein; KEGG: ajs:Ajs_1855 integrase catalytic subunit. (76 aa) |
| | Tint_1089 | PFAM: Integrase catalytic region; KEGG: vei:Veis_4709 integrase catalytic subunit. (298 aa) |
| | Tint_1090 | PFAM: transposase IS3/IS911 family protein; KEGG: vei:Veis_4708 transposase IS3/IS911 family protein. (98 aa) |
| | Tint_1107 | PFAM: Uracil-DNA glycosylase superfamily; KEGG: tgr:Tgr7_1908 hypothetical protein. (227 aa) |
| | uvrC | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (647 aa) |
| | Tint_1137 | KEGG: bcj:BCAL2971 hypothetical protein. (110 aa) |
| | Tint_1139 | KEGG: reh:H16_B2382 putative helicase; PFAM: Primase 2; SMART: AAA ATPase. (751 aa) |
| | Tint_1145 | PFAM: integrase family protein; KEGG: ajs:Ajs_3340 phage integrase family protein. (440 aa) |
| | mutL | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (613 aa) |
| | lexA | Transcriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (243 aa) |
| | Tint_0002 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (371 aa) |
| | gyrB | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (827 aa) |
| | Tint_0035 | Transposase; KEGG: eba:ebA4604 transposase. (344 aa) |
| | Tint_0071 | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (166 aa) |
| | Tint_0106 | PFAM: MT-A70 family protein; KEGG: ajs:Ajs_0426 MT-A70 family protein; Belongs to the MT-A70-like family. (229 aa) |
| | Tint_0107 | PFAM: Restriction endonuclease BglII; KEGG: ajs:Ajs_0427 hypothetical protein. (196 aa) |
| | Tint_0146 | TIGRFAM: DNA polymerase III, delta subunit; KEGG: bac:BamMC406_0577 DNA polymerase III subunit delta; PFAM: DNA polymerase III delta. (363 aa) |
| | Tint_0197 | PFAM: transposase IS4 family protein; KEGG: eba:p2A213 transposase. (565 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (352 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (757 aa) |
| | apaG | PFAM: ApaG domain protein; KEGG: cti:RALTA_A2768 ApaG. (124 aa) |
| | Tint_3103 | PFAM: integrase family protein; KEGG: tmz:Tmz1t_0253 integrase family protein; Belongs to the 'phage' integrase family. (423 aa) |
| | Tint_3101 | KEGG: avn:Avin_49670 hypothetical protein. (1032 aa) |
| | Tint_3100 | KEGG: avn:Avin_49680 hypothetical protein. (824 aa) |
| | Tint_3073 | PFAM: transposase IS4 family protein; KEGG: ajs:Ajs_2718 transposase, IS4 family protein. (329 aa) |
| | Tint_3068 | KEGG: ppr:PBPRB1139 hypothetical protein. (173 aa) |
| | Tint_3017 | PFAM: Integrase catalytic region; KEGG: vap:Vapar_2113 integrase catalytic region. (493 aa) |
| | Tint_3015 | KEGG: tmz:Tmz1t_4040 hypothetical protein. (394 aa) |
| | Tint_2982 | PFAM: Integrase catalytic region; KEGG: vap:Vapar_0682 integrase catalytic region. (510 aa) |
| | Tint_2944 | PFAM: protein of unknown function DUF1631; KEGG: mpt:Mpe_A0847 hypothetical protein. (790 aa) |
| | Tint_2937 | PFAM: integrase family protein; KEGG: vap:Vapar_0686 integrase family protein. (443 aa) |
| | Tint_2929 | Hypothetical protein; KEGG: tau:Tola_2276 CP4-57 prophage; hypothetical protein. (496 aa) |
| | Tint_2924 | TIGRFAM: phage/plasmid-related protein TIGR03299; KEGG: bcj:BCAL2507 hypothetical protein. (311 aa) |
| | Tint_2918 | PFAM: transposase IS3/IS911 family protein; KEGG: vei:Veis_4708 transposase IS3/IS911 family protein. (98 aa) |
| | Tint_2917 | PFAM: Integrase catalytic region; KEGG: vei:Veis_2765 integrase catalytic subunit. (298 aa) |
| | Tint_2915 | KEGG: pst:PSPTO_0037 helicase domain protein; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. (1676 aa) |
| | Tint_2913 | PFAM: Peptidase S24/S26A/S26B, conserved region; KEGG: xcc:XCC2963 polymerase V subunit; Belongs to the peptidase S24 family. (165 aa) |
| | Tint_2912 | DNA-directed DNA polymerase; KEGG: xcc:XCC2964 polymerase V subunit; PFAM: UMUC domain protein DNA-repair protein. (431 aa) |
| | Tint_2908 | PFAM: transposase IS3/IS911 family protein; KEGG: vei:Veis_4708 transposase IS3/IS911 family protein. (98 aa) |
| | Tint_2906 | Hypothetical protein; KEGG: cti:pRALTA_0580 transposase, IS3 family. (68 aa) |
| | Tint_2842 | KEGG: hde:HDEF_0920 hypothetical protein. (76 aa) |
| | Tint_2835 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (558 aa) |
| | Tint_2792 | SWIB/MDM2 domain protein; KEGG: bpt:Bpet0685 hypothetical protein; PFAM: SWIB/MDM2 domain protein; SMART: SWIB domain. (99 aa) |
| | Tint_2783 | PFAM: restriction endonuclease; KEGG: afw:Anae109_1084 restriction endonuclease. (307 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (195 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (190 aa) |
| | recD | Exodeoxyribonuclease V, alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (691 aa) |
| | recB | Exodeoxyribonuclease V, beta subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (1202 aa) |
| | recC | Exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (1173 aa) |
| | Tint_2651 | PFAM: transposase IS4 family protein; KEGG: rso:RSc1704 ISRSO18-transposase protein. (320 aa) |
| | Tint_2578 | PFAM: DNA polymerase III chi subunit HolC; KEGG: bpt:Bpet1770 DNA polymerase III, chi subunit. (141 aa) |
| | Tint_2552 | PFAM: Integrase catalytic region; KEGG: vap:Vapar_0682 integrase catalytic region. (510 aa) |
| | rep | UvrD/REP helicase; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (669 aa) |
| | Tint_2486 | PFAM: Integrase catalytic region; KEGG: vap:Vapar_0682 integrase catalytic region. (510 aa) |
| | Tint_2458 | PFAM: transposase IS3/IS911 family protein; KEGG: vei:Veis_4708 transposase IS3/IS911 family protein. (98 aa) |
| | Tint_2438 | DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: bte:BTH_I0984 DNA polymerase III subunit alpha; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type. (1146 aa) |
| | Tint_2413 | AAA ATPase central domain protein; KEGG: lch:Lcho_0758 recombination factor protein RarA; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. (470 aa) |
| | Tint_2404 | KEGG: bpy:Bphyt_2920 HAD-superfamily hydrolase, subfamily IA, variant 1; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase. (219 aa) |
| | recO | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (266 aa) |
| | Tint_2366 | KEGG: lch:Lcho_3830 ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase. (637 aa) |
| | Tint_2365 | KEGG: reu:Reut_A0211 hypothetical protein. (152 aa) |
| | xerC | Integrase family protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (336 aa) |
| | Tint_2222 | PFAM: protein of unknown function DUF511; KEGG: pac:PPA0576 hypothetical protein. (276 aa) |
| | Tint_2209 | PFAM: integrase family protein; KEGG: dar:Daro_3654 phage integrase; Belongs to the 'phage' integrase family. (348 aa) |
| | Tint_2201 | DNA topoisomerase; KEGG: rbi:RB2501_04285 hypothetical protein; PFAM: Relaxase/mobilization nuclease family protein. (718 aa) |
| | Tint_2199 | KEGG: hypothetical protein. (335 aa) |
| | Tint_2181 | TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; PFAM: RQC domain; DEAD/DEAH box helicase domain protein; helicase domain protein; HRDC domain protein; KEGG: bgl:bglu_1g02520 ATP-dependent DNA helicase RecQ; SMART: DEAD-like helicase; helicase domain protein; HRDC domain protein. (617 aa) |
| | priB | Single-strand binding protein/Primosomal replication protein n; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (96 aa) |
| | Tint_2117 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (452 aa) |
| | Tint_2069 | PFAM: integrase family protein; KEGG: vei:Veis_3652 phage integrase family protein; Belongs to the 'phage' integrase family. (392 aa) |
| | Tint_2028 | KEGG: afr:AFE_1569 single-strand binding protein; TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n. (142 aa) |
| | Tint_2018 | TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; KEGG: afe:Lferr_0283 DNA topoisomerase III; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. (723 aa) |
| | Tint_2016 | Site-specific DNA-methyltransferase (adenine-specific); KEGG: gur:Gura_0593 DNA methylase N-4/N-6 domain-containing protein; PFAM: DNA methylase N-4/N-6 domain protein. (1138 aa) |
| | Tint_2015 | PFAM: type III restriction protein res subunit; KEGG: aeh:Mlg_1542 DEAD/DEAH box helicase domain-containing protein. (1041 aa) |
| | Tint_2009 | PFAM: Relaxase/mobilization nuclease family protein; KEGG: pna:Pnap_2533 relaxase/mobilization nuclease family protein. (711 aa) |
| | Tint_1981 | KEGG: pna:Pnap_2528 hypothetical protein. (841 aa) |
| | Tint_1979 | PFAM: domain of unknown function DUF1738; KEGG: pna:Pnap_2529 hypothetical protein. (874 aa) |
| | Tint_1950 | KEGG: neu:NE2539 hypothetical protein. (412 aa) |
| | Tint_1946 | PFAM: transposase IS4 family protein; KEGG: ajs:Ajs_2718 transposase, IS4 family protein. (327 aa) |
| | Tint_1942 | PFAM: integrase family protein; KEGG: ctt:CtCNB1_1933 phage integrase. (208 aa) |
| | Tint_1940 | PFAM: transposase IS4 family protein; KEGG: app:CAP2UW1_4671 hypothetical protein. (451 aa) |
| | Tint_1932 | KEGG: afe:Lferr_1426 integrase catalytic region; manually curated; PFAM: Integrase catalytic region. (302 aa) |
| | Tint_1931 | KEGG: dia:Dtpsy_3254 transposase IS3/IS911 family protein. (86 aa) |
| | Tint_1930 | KEGG: dda:Dd703_2943 relaxase/mobilization nuclease family protein. (102 aa) |
| | Tint_1928 | PFAM: integrase family protein; KEGG: cak:Caul_0341 integrase family protein; Belongs to the 'phage' integrase family. (401 aa) |
| | Tint_1927 | PFAM: integrase family protein; KEGG: rru:Rru_A3316 phage integrase; Belongs to the 'phage' integrase family. (434 aa) |
| | Tint_1917 | PFAM: transposase IS3/IS911 family protein; KEGG: pna:Pnap_4650 transposase IS3/IS911 family protein. (88 aa) |
| | Tint_1916 | PFAM: Integrase catalytic region; KEGG: xca:xccb100_2471 IS1477 transposase ORFB. (277 aa) |
| | Tint_1908 | PFAM: transposase IS3/IS911 family protein; KEGG: dia:Dtpsy_3254 transposase IS3/IS911 family protein. (107 aa) |
| | Tint_1907 | KEGG: afe:Lferr_1426 integrase catalytic region; manually curated; PFAM: Integrase catalytic region. (302 aa) |
| | Tint_1893 | KEGG: pna:Pnap_5005 putative DNA helicase. (329 aa) |
| | Tint_1892 | PFAM: replication C family protein; KEGG: sty:HCM1.221 putative replication protein. (367 aa) |
| | dnaE2 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1037 aa) |
| | Tint_1889 | KEGG: vap:Vapar_4537 hypothetical protein. (458 aa) |
| | Tint_1880 | PFAM: Integrase catalytic region; KEGG: xca:xccb100_2471 IS1477 transposase ORFB. (277 aa) |
| | Tint_1879 | PFAM: transposase IS3/IS911 family protein; KEGG: pna:Pnap_4650 transposase IS3/IS911 family protein. (88 aa) |
| | Tint_1877 | PFAM: integrase family protein; KEGG: reh:H16_A2469 phage integrase family protein; Belongs to the 'phage' integrase family. (340 aa) |
| | gyrA | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (868 aa) |
| | Tint_1865 | Histone family protein DNA-binding protein; KEGG: vap:Vapar_1613 integration host factor, beta subunit; PFAM: histone family protein DNA-binding protein; SMART: histone family protein DNA-binding protein; Belongs to the bacterial histone-like protein family. (110 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (612 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (203 aa) |
| | uvrB | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (697 aa) |
| | Tint_1794 | Transposase; KEGG: eba:ebA4604 transposase. (346 aa) |
| | dnaJ | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (376 aa) |
| | Tint_1750 | KEGG: pol:Bpro_1995 twitching motility protein; TIGRFAM: twitching motility protein; PFAM: type II secretion system protein E. (383 aa) |
| | Tint_1748 | KEGG: dac:Daci_3613 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; TIGRFAM: protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; modification methylase, HemK family; PFAM: methyltransferase small; Belongs to the protein N5-glutamine methyltransferase family. (316 aa) |
| | Tint_1747 | KEGG: mpt:Mpe_A1802 putative ATP-binding ABC transporter protein; PFAM: ABC transporter related; SMART: AAA ATPase. (649 aa) |
| | Tint_1709 | KEGG: ace:Acel_0734 DNA mismatch repair protein MutS domain-containing protein; PFAM: DNA mismatch repair protein MutS domain protein; SMART: DNA mismatch repair protein MutS domain protein. (538 aa) |
| | Tint_1708 | PFAM: DNA mismatch repair protein MutS domain protein; KEGG: mdi:METDI2577 putative DNA mismatch repair protein. (504 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1160 aa) |
| | Tint_1686 | KEGG: dac:Daci_4218 hypothetical protein. (121 aa) |
| | xseA | Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (448 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (624 aa) |
| | Tint_1640 | PFAM: transposase IS3/IS911 family protein; KEGG: pna:Pnap_4650 transposase IS3/IS911 family protein. (88 aa) |
| | Tint_1639 | PFAM: Integrase catalytic region; KEGG: xca:xccb100_2471 IS1477 transposase ORFB. (277 aa) |
| | xseB | Exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (88 aa) |
| | mutS | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (860 aa) |
| | Tint_1581 | PFAM: Integrase catalytic region; KEGG: reu:Reut_C5938 integrase catalytic subunit. (276 aa) |
| | Tint_1580 | PFAM: transposase IS3/IS911 family protein; KEGG: reu:Reut_C5937 transposase IS3/IS911. (105 aa) |
| | Tint_1578 | KEGG: ajs:Ajs_3594 integrase catalytic subunit; manually curated; PFAM: Integrase catalytic region. (514 aa) |
| | Tint_1563 | PFAM: transposase IS4 family protein; KEGG: eba:p2A213 transposase. (565 aa) |
| | Tint_1556 | KEGG: net:Neut_2505 phage integrase family protein. (175 aa) |
| | Tint_1549 | PFAM: Putative helicase A859L; KEGG: pau:PA14_15600 hypothetical protein. (401 aa) |
| | Tint_1540 | PFAM: Relaxase/mobilization nuclease family protein; KEGG: hna:Hneap_0481 relaxase/mobilization nuclease family protein. (800 aa) |
| | Tint_1538 | PFAM: integrase family protein; KEGG: ccs:CCNA_00480 bacteriophage P4 integrase; Belongs to the 'phage' integrase family. (398 aa) |
| | Tint_1536 | KEGG: vap:Vapar_6342 transposase IS116/IS110/IS902 family protein; manually curated; PFAM: transposase IS116/IS110/IS902 family protein. (198 aa) |
| | Tint_1533 | KEGG: plt:Plut_1899 abortive infection protein, internal deletion. (397 aa) |
| | Tint_1531 | PFAM: DNA methylase N-4/N-6 domain protein; KEGG: gme:Gmet_0676 DNA methylase N-4/N-6. (508 aa) |
| | Tint_1529 | PFAM: restriction endonuclease; KEGG: rfr:Rfer_1819 restriction endonuclease. (306 aa) |
| | Tint_1527 | PFAM: transposase IS4 family protein; KEGG: avn:Avin_24710 transposase, IS4. (341 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa) |
| | smc | Chromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1177 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (688 aa) |
| | Tint_1498 | PFAM: Integrase catalytic region; KEGG: xca:xccb100_2471 IS1477 transposase ORFB. (277 aa) |
| | Tint_1497 | PFAM: transposase IS3/IS911 family protein; KEGG: pna:Pnap_4650 transposase IS3/IS911 family protein. (88 aa) |
| | Tint_1493 | KEGG: nmu:Nmul_A0747 methylated-DNA--protein-cysteine methyltransferase; TIGRFAM: methylated-DNA/protein-cysteine methyltransferase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding. (170 aa) |
| | xerD | Tyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (317 aa) |
| | Tint_1481 | Hydrolase, TatD family; KEGG: pol:Bpro_2516 TatD-related deoxyribonuclease; TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease. (268 aa) |
| | Tint_1479 | KEGG: bpt:Bpet2503 DNA polymerase III, delta' subunit. (360 aa) |
| | Tint_1423 | KEGG: lch:Lcho_1246 exodeoxyribonuclease III Xth; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase. (253 aa) |
| | Tint_1414 | Modification methylase, HemK family; KEGG: tgr:Tgr7_2383 methylase of polypeptide chain release factors-like protein; TIGRFAM: modification methylase, HemK family; PFAM: methyltransferase small. (324 aa) |
