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| | srkA | Aminoglycoside phosphotransferase; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (324 aa) |
| | Tint_0530 | Integral membrane sensor signal transduction histidine kinase; PFAM: histidine kinase internal region; KEGG: ajs:Ajs_3313 histidine kinase internal region. (347 aa) |
| | Tint_0522 | KEGG: mpt:Mpe_A3217 signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (554 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (375 aa) |
| | Tint_0450 | PFAM: aminoglycoside phosphotransferase; KEGG: ajs:Ajs_3456 hypothetical protein. (510 aa) |
| | Tint_0437 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (809 aa) |
| | Tint_0427 | Aspartate kinase; KEGG: bpr:GBP346_A2661 asparate kinase, monofunctional class; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (417 aa) |
| | Tint_0408 | PFAM: PfkB domain protein; KEGG: ajs:Ajs_3635 ribokinase-like domain-containing protein. (314 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (343 aa) |
| | cysC | Sulfate adenylyltransferase, large subunit; Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family. (609 aa) |
| | pgk | KEGG: cti:RALTA_A0522 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (401 aa) |
| | Tint_0137 | Phosphoribulokinase; KEGG: dar:Daro_3627 phosphoribulokinase/uridine kinase; PFAM: phosphoribulokinase/uridine kinase. (291 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (323 aa) |
| | anmK | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (370 aa) |
| | Tint_0068 | KEGG: har:HEAR1623 sensory histidine kinase in two-component regulatory system wtih KdpE, regulation of potassium translocation; PFAM: Osmosensitive K channel His kinase sensor; UspA domain protein; histidine kinase A domain protein; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (914 aa) |
| | Tint_0053 | Integral membrane sensor signal transduction histidine kinase; Manually curated; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: nmu:Nmul_A1159 periplasmic sensor signal transduction histidine kinase; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (487 aa) |
| | hprK | HPr kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). (317 aa) |
| | glk | TIGRFAM: glucokinase; KEGG: cvi:CV_0147 glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (326 aa) |
| | ubiB | 2-polyprenylphenol 6-hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (523 aa) |
| | Tint_2191 | Pyruvate kinase; KEGG: app:CAP2UW1_1860 pyruvate kinase; PFAM: Pyruvate kinase barrel. (620 aa) |
| | Tint_2175 | 1-phosphofructokinase; KEGG: rru:Rru_A1971 PfkB; TIGRFAM: 1-phosphofructokinase; PFAM: PfkB domain protein; Belongs to the carbohydrate kinase PfkB family. (312 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa) |
| | Tint_2123 | Protein of unknown function DUF299; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (272 aa) |
| | Tint_2122 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (795 aa) |
| | Tint_2093 | KEGG: lch:Lcho_3508 polysaccharide chain length determinant protein; TIGRFAM: polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; PFAM: lipopolysaccharide biosynthesis protein. (535 aa) |
| | Tint_1845 | Integral membrane sensor signal transduction histidine kinase; KEGG: afr:AFE_2031 sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (446 aa) |
| | Tint_1820 | PFAM: protein of unknown function DUF344; KEGG: hna:Hneap_0972 protein of unknown function DUF344. (265 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | Tint_1716 | PAS/PAC sensor signal transduction histidine kinase; TIGRFAM: phosphate regulon sensor kinase PhoR; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; KEGG: bph:Bphy_0888 multi-sensor signal transduction histidine kinase; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein. (458 aa) |
| | ppk | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (696 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (348 aa) |
| | Tint_1677 | PFAM: protein of unknown function DUF343; KEGG: cti:RALTA_A0561 conserved hypothetical protein, DUF343; Belongs to the UPF0434 family. (75 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | Tint_1496 | PFAM: ROK family protein; KEGG: tmz:Tmz1t_4078 ROK family protein. (336 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (215 aa) |
| | Tint_1421 | KEGG: pol:Bpro_1809 signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (361 aa) |
| | Tint_1369 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (738 aa) |
| | Tint_1365 | Integral membrane sensor signal transduction histidine kinase; KEGG: dac:Daci_2851 histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein. (448 aa) |
| | Tint_1329 | Riboflavin biosynthesis protein RibF; KEGG: lch:Lcho_1237 bifunctional riboflavin kinase/FMN adenylyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (323 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (504 aa) |
| | Tint_1278 | Multi-sensor signal transduction histidine kinase; Member of a two-component regulatory system. (486 aa) |
| | thrB | TIGRFAM: homoserine kinase; KEGG: aav:Aave_1928 homoserine kinase; PFAM: aminoglycoside phosphotransferase; Belongs to the pseudomonas-type ThrB family. (313 aa) |
| | Tint_1233 | CheA signal transduction histidine kinase; KEGG: azo:azo0408 putative chemotaxis protein histidine kinase; PFAM: CheW domain protein; ATP-binding region ATPase domain protein; Hpt domain protein; Signal transducing histidine kinase homodimeric; SMART: CheW domain protein; Hpt domain protein; ATP-binding region ATPase domain protein. (746 aa) |
| | Tint_1202 | Putative CheA signal transduction histidine kinase; KEGG: bpa:BPP1221 DNA polymerase III subunits gamma and tau. (355 aa) |
| | Tint_1176 | CheA signal transduction histidine kinase; KEGG: amc:MADE_02867 chemotaxis protein CheA; PFAM: ATP-binding region ATPase domain protein; Hpt domain protein; Signal transducing histidine kinase homodimeric; CheW domain protein; SMART: Hpt domain protein; ATP-binding region ATPase domain protein; CheW domain protein. (674 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | Tint_1128 | KEGG: tbd:Tbd_2353 periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein. (456 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (358 aa) |
| | Tint_1035 | KEGG: rpi:Rpic_0784 RfaE bifunctional protein; TIGRFAM: rfaE bifunctional protein; PFAM: PfkB domain protein. (309 aa) |
| | Tint_1026 | KEGG: pna:Pnap_2990 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (168 aa) |
| | Tint_0878 | TIGRFAM: 1-phosphofructokinase; KEGG: afr:AFE_1807 carbohydrate kinase, PfkB family; PFAM: PfkB domain protein. (317 aa) |
| | Tint_0826 | PFAM: PTS system fructose subfamily IIA component; KEGG: rso:RSc0346 hypothetical protein. (153 aa) |
| | Tint_0822 | KEGG: vei:Veis_2634 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein. (371 aa) |
| | Tint_0813 | Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (583 aa) |
| | Tint_0807 | TIGRFAM: pyruvate kinase; KEGG: mpt:Mpe_A0290 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (477 aa) |
| | Tint_0760 | PFAM: SlyX family protein; KEGG: bav:BAV1796 protein SlyX. (75 aa) |
| | Tint_0682 | KEGG: tbd:Tbd_2689 periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein. (437 aa) |
| | Tint_0678 | Integral membrane sensor signal transduction histidine kinase; KEGG: vap:Vapar_2385 histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (456 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (181 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (501 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (304 aa) |
| | Tint_3070 | KEGG: aeh:Mlg_1149 periplasmic sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein. (479 aa) |
| | Tint_3064 | Integral membrane sensor signal transduction histidine kinase; KEGG: tmz:Tmz1t_0383 histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: histidine kinase A domain protein; ATP-binding region ATPase domain protein. (498 aa) |
| | Tint_3020 | KEGG: lch:Lcho_1579 death-on-curing family protein; TIGRFAM: death-on-curing family protein; PFAM: filamentation induced by cAMP protein Fic. (128 aa) |
| | Tint_2968 | KEGG: app:CAP2UW1_2348 integral membrane sensor signal transduction histidine kinase; PFAM: CHASE2 domain protein; histidine kinase A domain protein; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (673 aa) |
| | Tint_2903 | KEGG: mpt:Mpe_A0274 multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; PAS fold-4 domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; PAS domain containing protein. (767 aa) |
| | Tint_2855 | KEGG: ajs:Ajs_1122 hydroxypyruvate reductase; PFAM: MOFRL domain protein. (435 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (297 aa) |
| | Tint_2825 | KEGG: oca:OCAR_7493 putative sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein. (751 aa) |
| | Tint_2740 | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (139 aa) |
| | aceK | (Isocitrate dehydrogenase (NADP(+))) kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (604 aa) |
| | Tint_2693 | PFAM: protein of unknown function DUF344; KEGG: bpr:GBP346_A0089 polyphosphate:AMP phosphotransferase. (277 aa) |
| | Tint_2679 | KEGG: mpt:Mpe_A0077 putative transmembrane sensor histidine kinase transcription regulator protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; Two-component sensor kinase domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (499 aa) |
| | Tint_2677 | PFAM: PEBP family protein; KEGG: tmz:Tmz1t_4061 protein of unknown function DUF524. (208 aa) |
| | Tint_2667 | KEGG: aav:Aave_3581 serine/threonine protein kinase; PFAM: Serine/threonine-protein kinase-like domain; SMART: serine/threonine protein kinase; Tyrosine-protein kinase, subgroup, catalytic domain. (359 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa) |
| | Tint_2633 | PFAM: protein of unknown function DUF344; KEGG: xau:Xaut_4684 hypothetical protein. (397 aa) |
| | Tint_2543 | CheA signal transduction histidine kinase; KEGG: mpt:Mpe_A3186 twitching motility protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; Hpt domain protein; Signal transducing histidine kinase homodimeric; CheW domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; Hpt domain protein; CheW domain protein. (1989 aa) |
| | Tint_2537 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: mpt:Mpe_A3192 hydroxymethylpyrimidine kinase. (308 aa) |
| | Tint_2473 | KEGG: dia:Dtpsy_0423 GAF sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; histidine kinase HAMP region domain protein; GAF domain protein; SMART: histidine kinase HAMP region domain protein; ATP-binding region ATPase domain protein. (643 aa) |
| | Tint_2432 | KEGG: gem:GM21_0023 hypothetical protein. (173 aa) |
| | Tint_2361 | TIGRFAM: phosphomethylpyrimidine kinase; KEGG: ajs:Ajs_1787 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (286 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (275 aa) |
| | coaX | Transcriptional activator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa) |
