STRINGSTRING
dxr dxr guaB guaB Tint_1602 Tint_1602 Tint_1595 Tint_1595 Tint_1393 Tint_1393 murB murB Tint_1300 Tint_1300 Tint_1149 Tint_1149 Tint_1132 Tint_1132 zwf zwf Tint_0990 Tint_0990 Tint_0875 Tint_0875 hisD hisD gpsA gpsA Tint_0484 Tint_0484 Tint_3193 Tint_3193 Tint_3007 Tint_3007 Tint_2855 Tint_2855 Tint_2718 Tint_2718 gpsA-2 gpsA-2 Tint_2601 Tint_2601 Tint_2567 Tint_2567 aroE aroE Tint_2512 Tint_2512 Tint_2424 Tint_2424 mdh mdh leuB leuB ilvC ilvC Tint_2112 Tint_2112
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (401 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa)
Tint_1602PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: gyc:GYMC61_0742 alcohol dehydrogenase zinc-binding domain protein. (372 aa)
Tint_1595PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: cti:RALTA_A1467 multifunctional: 3-hydroxybutyryl-CoA epimerase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, enoyl-CoA hydratase (N-terminal); 3-hydroxyacyl-CoA dehydrogenase (C-terminal). (697 aa)
Tint_1393TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: cti:RALTA_A2531 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (416 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (341 aa)
Tint_1300KEGG: lch:Lcho_3069 nucleotide sugar dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (426 aa)
Tint_1149TIGRFAM: nucleotide sugar dehydrogenase; KEGG: net:Neut_1093 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (441 aa)
Tint_1132TIGRFAM: tartrate dehydrogenase; KEGG: vei:Veis_2698 tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (367 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (496 aa)
Tint_09902-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (334 aa)
Tint_0875TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; KEGG: lch:Lcho_1612 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; Belongs to the PdxA family. (329 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (445 aa)
gpsAPFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: mpt:Mpe_A0717 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (347 aa)
Tint_0484PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: vei:Veis_2069 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (328 aa)
Tint_3193PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: dia:Dtpsy_1729 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding. (336 aa)
Tint_3007PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: azo:azo0301 3-hydroxy-acyl-CoA dehydrogenase. (490 aa)
Tint_2855KEGG: ajs:Ajs_1122 hydroxypyruvate reductase; PFAM: MOFRL domain protein. (435 aa)
Tint_2718PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: bgl:bglu_1g32580 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (316 aa)
gpsA-2PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: dsh:Dshi_3830 glycerol-3-phosphate dehydrogenase (NAD(P)(+)); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (390 aa)
Tint_2601PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; Enoyl-CoA hydratase/isomerase; KEGG: reh:H16_A0461 3-hydroxyacyl-CoA dehydrogenase. (799 aa)
Tint_2567dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (302 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa)
Tint_2512KEGG: vap:Vapar_4079 isocitrate dehydrogenase (NAD(+)); PFAM: isocitrate/isopropylmalate dehydrogenase. (343 aa)
Tint_2424Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (366 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
Tint_2112KEGG: mpt:Mpe_A1541 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein. (436 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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