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dnaA dnaA gyrB gyrB surA surA Tint_0168 Tint_0168 Tint_0178 Tint_0178 Tint_0191 Tint_0191 Tint_0224 Tint_0224 queA queA Tint_0320 Tint_0320 Tint_0419 Tint_0419 Tint_0420 Tint_0420 parC parC parE parE gmhA gmhA Tint_0496 Tint_0496 Tint_0583 Tint_0583 Tint_0597 Tint_0597 Tint_0616 Tint_0616 groL groL Tint_0700 Tint_0700 Tint_0706 Tint_0706 Tint_0716 Tint_0716 Tint_0730 Tint_0730 gpmA gpmA Tint_0782 Tint_0782 Tint_0788 Tint_0788 Tint_1095 Tint_1095 Tint_1134 Tint_1134 truB truB Tint_1312 Tint_1312 nnrD nnrD Tint_1419 Tint_1419 Tint_1436 Tint_1436 Tint_1595 Tint_1595 Tint_1648 Tint_1648 tig tig glmM glmM Tint_1779 Tint_1779 cmk cmk apaG apaG Tint_3122 Tint_3122 Tint_3120 Tint_3120 Tint_3119 Tint_3119 Tint_3093 Tint_3093 Tint_3080 Tint_3080 Tint_2860 Tint_2860 Tint_2857 Tint_2857 Tint_2792 Tint_2792 Tint_2739 Tint_2739 Tint_2728 Tint_2728 fabA fabA Tint_2700 Tint_2700 Tint_2565 Tint_2565 hemL hemL Tint_2506 Tint_2506 Tint_2481 Tint_2481 Tint_2405 Tint_2405 truA truA Tint_1870 Tint_1870 trpF trpF rpiA rpiA tpiA tpiA Tint_2250 Tint_2250 purE purE dapF dapF Tint_2189 Tint_2189 icmF icmF murI murI Tint_2054 Tint_2054 Tint_2020 Tint_2020 Tint_2018 Tint_2018 gyrA gyrA hisA hisA Tint_0945 Tint_0945 hldD hldD pgi pgi
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (484 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (827 aa)
surASurA domain protein; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (459 aa)
Tint_0168PFAM: aminotransferase class-III; KEGG: cvi:CV_2819 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
Tint_0178Glutamate--putrescine ligase; KEGG: mpt:Mpe_A1901 L-glutamine synthetase; PFAM: glutamine synthetase catalytic region. (459 aa)
Tint_0191KpsF/GutQ family protein; SMART: CBS domain containing protein; TIGRFAM: KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. (332 aa)
Tint_0224PFAM: Phosphoglycerate mutase; KEGG: pol:Bpro_4091 phosphoglycerate mutase. (216 aa)
queAS-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (406 aa)
Tint_0320PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: min:Minf_2079 parvulin-like peptidyl-prolyl isomerase. (282 aa)
Tint_0419Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (163 aa)
Tint_0420Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (214 aa)
parCDNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (777 aa)
parEDNA topoisomerase (ATP-hydrolyzing); Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (652 aa)
gmhASugar isomerase (SIS); Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (199 aa)
Tint_0496KEGG: lpf:lpl0790 N-acylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; PFAM: UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (463 aa)
Tint_0583TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; KEGG: mpt:Mpe_A0265 DNA topoisomerase III; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. (843 aa)
Tint_0597Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (367 aa)
Tint_0616PFAM: Phosphoglycerate mutase; KEGG: rpd:RPD_0651 phosphoglycerate mutase. (225 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (546 aa)
Tint_0700KEGG: hna:Hneap_2228 hypothetical protein. (208 aa)
Tint_0706KEGG: hna:Hneap_2228 hypothetical protein. (197 aa)
Tint_0716KEGG: hna:Hneap_1057 hypothetical protein. (196 aa)
Tint_0730PFAM: Aldose 1-epimerase; KEGG: tbd:Tbd_2730 dihydroxyacid dehydratase; Belongs to the glucose-6-phosphate 1-epimerase family. (300 aa)
gpmAPhosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (235 aa)
Tint_0782KEGG: mpt:Mpe_A2569 putative FkbP-type peptidyl-prolyl cis-trans isomerase. (168 aa)
Tint_0788KEGG: aha:AHA_4103 UDP-glucose 4-epimerase; TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (340 aa)
Tint_1095PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: similar to phosphoglucomutase 1. (543 aa)
Tint_1134PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: rpf:Rpic12D_1532 PpiC-type peptidyl-prolyl cis-trans isomerase. (640 aa)
truBtRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (345 aa)
Tint_1312Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (342 aa)
nnrDCarbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (525 aa)
Tint_1419KEGG: vap:Vapar_1632 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (471 aa)
Tint_1436PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: mms:mma_1544 PpiC-type peptidyl-prolyl cis-trans isomerase. (262 aa)
Tint_1595PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: cti:RALTA_A1467 multifunctional: 3-hydroxybutyryl-CoA epimerase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, enoyl-CoA hydratase (N-terminal); 3-hydroxyacyl-CoA dehydrogenase (C-terminal). (697 aa)
Tint_1648KEGG: pol:Bpro_0950 peptidylprolyl isomerase, FKBP-type. (175 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (444 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (438 aa)
Tint_1779RNA-binding S4 domain protein; KEGG: vap:Vapar_2182 pseudouridine synthase; PFAM: RNA-binding S4 domain protein; pseudouridine synthase; SMART: RNA-binding S4 domain protein; Belongs to the pseudouridine synthase RsuA family. (562 aa)
cmk3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. (658 aa)
apaGPFAM: ApaG domain protein; KEGG: cti:RALTA_A2768 ApaG. (124 aa)
Tint_3122TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: bgl:bglu_1g04420 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (235 aa)
Tint_3120KEGG: rfr:Rfer_0068 putative lipoprotein transmembrane. (191 aa)
Tint_3119KEGG: dia:Dtpsy_0355 putative lipoprotein transmembrane. (207 aa)
Tint_3093KEGG: reh:PHG074 putative sedoheptulose 7-phosphate isomerase. (231 aa)
Tint_3080PFAM: hydrogenase-1 expression HyaE; KEGG: avn:Avin_50540 hydrogenase expression/formation protein, HoxO; Belongs to the HupG/HyaE family. (136 aa)
Tint_2860KEGG: bmj:BMULJ_04492 4-oxalocrotonate tautomerase; TIGRFAM: 4-oxalocrotonate tautomerase family enzyme; PFAM: 4-oxalocrotonate tautomerase. (63 aa)
Tint_2857TIGRFAM: hydroxypyruvate isomerase; KEGG: pol:Bpro_4562 hydroxypyruvate isomerase; PFAM: Xylose isomerase domain protein TIM barrel; Belongs to the hyi family. (257 aa)
Tint_2792SWIB/MDM2 domain protein; KEGG: bpt:Bpet0685 hypothetical protein; PFAM: SWIB/MDM2 domain protein; SMART: SWIB domain. (99 aa)
Tint_2739KEGG: dia:Dtpsy_2390 hypothetical protein. (152 aa)
Tint_2728PFAM: DSBA oxidoreductase; KEGG: app:CAP2UW1_4329 DsbA oxidoreductase. (201 aa)
fabABeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (171 aa)
Tint_2700Disulfide bond isomerase, DsbC/G-like protein; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily. (245 aa)
Tint_2565dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (187 aa)
hemLGlutamate-1-semialdehyde-2,1-aminomutase; KEGG: rme:Rmet_0667 glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III. (429 aa)
Tint_2506KEGG: har:HEAR2424 hypothetical protein. (203 aa)
Tint_2481PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: bpl:BURPS1106A_A1541 peptidyl-prolyl cis-trans isomerase domain-containing protein. (226 aa)
Tint_2405Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (329 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (257 aa)
Tint_1870KEGG: pol:Bpro_1792 chorismate mutase / prephenate dehydratase; TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein. (365 aa)
trpFKEGG: lch:Lcho_1681 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (220 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (220 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
Tint_2250KEGG: reh:H16_A1172 hypothetical protein. (345 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (287 aa)
Tint_2189PFAM: pseudouridine synthase; RNA-binding S4 domain protein; KEGG: pol:Bpro_0606 ribosomal large subunit pseudouridine synthase F. (300 aa)
icmFmethylmalonyl-CoA mutase, large subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1093 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (263 aa)
Tint_2054PFAM: 4-oxalocrotonate tautomerase; KEGG: bxe:Bxe_C0717 hypothetical protein. (139 aa)
Tint_2020PFAM: Chorismate mutase, type II; KEGG: har:HEAR2642 putative chorismate mutase (partial). (111 aa)
Tint_2018TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; KEGG: afe:Lferr_0283 DNA topoisomerase III; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. (723 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (868 aa)
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: reh:H16_A3411 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. (244 aa)
Tint_0945Phosphoglucomutase; KEGG: rme:Rmet_2716 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase. (458 aa)
hldDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (330 aa)
pgiPFAM: phosphoglucose isomerase (PGI); KEGG: bpt:Bpet4022 hypothetical protein; Belongs to the GPI family. (502 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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