STRINGSTRING
kynU kynU Tint_0267 Tint_0267 Tint_0187 Tint_0187 Tint_0179 Tint_0179 Tint_0176 Tint_0176 Tint_0168 Tint_0168 serC serC hisC-2 hisC-2 Tint_1849 Tint_1849 Tint_1752 Tint_1752 Tint_1693 Tint_1693 Tint_1092 Tint_1092 iscS iscS Tint_0336 Tint_0336 Tint_1987 Tint_1987 argD argD hisC hisC glyA glyA lysA lysA Tint_2467 Tint_2467 Tint_0597 Tint_0597 Tint_2431 Tint_2431 metZ metZ Tint_2113 Tint_2113 hemL hemL Tint_2583 Tint_2583 Tint_2788 Tint_2788 Tint_2790 Tint_2790 Tint_2812 Tint_2812 ilvA ilvA Tint_1874 Tint_1874
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (427 aa)
Tint_0267Transcriptional regulator, GntR family with aminotransferase domain; KEGG: lch:Lcho_4183 transcriptional regulator; PFAM: aminotransferase class I and II; regulatory protein GntR HTH; SMART: regulatory protein GntR HTH. (477 aa)
Tint_0187KEGG: mpt:Mpe_A1910 4-aminobutyrate aminotransferase; TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa)
Tint_0179PFAM: aminotransferase class-III; KEGG: lch:Lcho_1738 putative aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (466 aa)
Tint_0176KEGG: pna:Pnap_2866 GntR family transcriptional regulator; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; SMART: regulatory protein GntR HTH. (505 aa)
Tint_0168PFAM: aminotransferase class-III; KEGG: cvi:CV_2819 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (367 aa)
hisC-2KEGG: rpf:Rpic12D_0846 histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (376 aa)
Tint_1849PFAM: aminotransferase class I and II; KEGG: mpt:Mpe_A2293 aromatic amino acid aminotransferase. (401 aa)
Tint_1752KEGG: aav:Aave_2485 succinyldiaminopimelate transaminase; TIGRFAM: succinyldiaminopimelate transaminase; PFAM: aminotransferase class I and II. (403 aa)
Tint_1693KEGG: mpt:Mpe_A1615 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (407 aa)
Tint_1092Glycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (827 aa)
iscSCysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (406 aa)
Tint_0336Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (243 aa)
Tint_1987PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: bac:BamMC406_4343 serine/threonine dehydratase. (331 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferase; KEGG: mpt:Mpe_A3029 acetylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa)
hisCKEGG: azo:azo3348 histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa)
Tint_2467Cysteine desulfurase, SufS subfamily; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (416 aa)
Tint_0597Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (367 aa)
Tint_2431PFAM: aminotransferase class I and II; KEGG: mpt:Mpe_A2950 aminotransferase. (393 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (404 aa)
Tint_2113PFAM: aminotransferase class I and II; KEGG: mpt:Mpe_A1540 aminotransferase AlaT. (410 aa)
hemLGlutamate-1-semialdehyde-2,1-aminomutase; KEGG: rme:Rmet_0667 glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III. (429 aa)
Tint_2583PFAM: aminotransferase class I and II; KEGG: ajs:Ajs_1915 putative aminotransferase. (387 aa)
Tint_2788Transcriptional regulator, GntR family with aminotransferase domain; KEGG: dac:Daci_0595 transcriptional regulator; PFAM: aminotransferase class I and II; regulatory protein GntR HTH; SMART: regulatory protein GntR HTH. (489 aa)
Tint_2790PFAM: aminotransferase class I and II; KEGG: lch:Lcho_3539 GntR family transcriptional regulator. (403 aa)
Tint_2812TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: lch:Lcho_4276 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (425 aa)
ilvAThreonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (516 aa)
Tint_1874PFAM: aminotransferase class-III; KEGG: bte:BTH_I1505 omega amino acid--pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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