STRINGSTRING
Tint_2077 Tint_2077 fumC fumC Tint_0287 Tint_0287 Tint_0286 Tint_0286 Tint_0285 Tint_0285 Tint_0284 Tint_0284 Tint_0283 Tint_0283 Tint_0244 Tint_0244 Tint_0240 Tint_0240 Tint_0239 Tint_0239 Tint_0111 Tint_0111 Tint_0044 Tint_0044 Tint_0013 Tint_0013 Tint_0012 Tint_0012 Tint_0291 Tint_0291 Tint_0606 Tint_0606 Tint_0614 Tint_0614 Tint_0626 Tint_0626 Tint_0634 Tint_0634 sucC sucC sucD sucD Tint_0889 Tint_0889 Tint_0900 Tint_0900 Tint_0942 Tint_0942 Tint_1070 Tint_1070 Tint_1073 Tint_1073 Tint_1111 Tint_1111 Tint_1304 Tint_1304 Tint_1305 Tint_1305 Tint_1306 Tint_1306 Tint_1344 Tint_1344 Tint_1345 Tint_1345 Tint_1359 Tint_1359 Tint_1393 Tint_1393 Tint_1461 Tint_1461 ubiE ubiE nuoN nuoN Tint_2256 Tint_2256 Tint_2257 Tint_2257 nuoK nuoK nuoI nuoI nuoH nuoH Tint_2262 Tint_2262 Tint_2264 Tint_2264 Tint_2275 Tint_2275 Tint_2333 Tint_2333 Tint_2335 Tint_2335 Tint_2337 Tint_2337 Tint_2338 Tint_2338 Tint_2339 Tint_2339 Tint_2340 Tint_2340 mdh mdh Tint_2344 Tint_2344 Tint_2347 Tint_2347 Tint_2478 Tint_2478 Tint_2591 Tint_2591 Tint_2593 Tint_2593 Tint_2604 Tint_2604 Tint_2639 Tint_2639 Tint_2645 Tint_2645 Tint_2692 Tint_2692 aceK aceK Tint_2796 Tint_2796 Tint_2957 Tint_2957 Tint_2959 Tint_2959 Tint_3054 Tint_3054 Tint_3055 Tint_3055 Tint_3056 Tint_3056 Tint_3075 Tint_3075 Tint_3076 Tint_3076 Tint_3077 Tint_3077 Tint_3084 Tint_3084 Tint_3089 Tint_3089 Tint_3090 Tint_3090 Tint_1699 Tint_1699 Tint_1700 Tint_1700 Tint_1701 Tint_1701 Tint_1702 Tint_1702 Tint_1704 Tint_1704 ppc ppc Tint_2193 Tint_2193
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Tint_2077KEGG: hna:Hneap_1847 hypothetical protein. (411 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (477 aa)
Tint_0287KEGG: eba:ebA4187 subunit of formate hydrogenlyase-like membrane complex, related to large subunit of hydrogenase. (508 aa)
Tint_0286Hypothetical protein; PFAM: NADH/Ubiquinone/plastoquinone (complex I); KEGG: rfr:Rfer_3289 hydrogenase 4 subunit F. (484 aa)
Tint_0285KEGG: rfr:Rfer_3290 hydrogenase 4 membrane component. (273 aa)
Tint_0284KEGG: rme:Rmet_4670 respiratory-chain NADH dehydrogenase, subunit 1. (325 aa)
Tint_0283Hypothetical protein; PFAM: NADH/Ubiquinone/plastoquinone (complex I); KEGG: eba:ebA4193 hydrogenase 4 subunit B. (672 aa)
Tint_0244PFAM: cytochrome B561; KEGG: tmz:Tmz1t_1861 cytochrome b561. (189 aa)
Tint_0240PFAM: cytochrome bd ubiquinol oxidase subunit I; KEGG: sfu:Sfum_3051 cytochrome bd ubiquinol oxidase, subunit I. (494 aa)
Tint_0239KEGG: ava:Ava_B0174 cytochrome bd ubiquinol oxidase, subunit II; TIGRFAM: cytochrome d ubiquinol oxidase, subunit II; PFAM: cytochrome bd ubiquinol oxidase subunit II. (341 aa)
Tint_0111Hypothetical protein; PFAM: NADH/Ubiquinone/plastoquinone (complex I); NADH-Ubiquinone oxidoreductase (complex I) chain 5/L domain protein; KEGG: nha:Nham_4321 NADH/ubiquinone/plastoquinone (complex I). (564 aa)
Tint_0044PFAM: cytochrome B561; KEGG: pna:Pnap_3658 cytochrome b561. (175 aa)
Tint_0013PFAM: cytochrome bd ubiquinol oxidase subunit I; KEGG: bav:BAV0991 cytochrome d ubiquinol oxidase subunit I. (545 aa)
Tint_0012KEGG: bav:BAV0992 cytochrome d ubiquinol oxidase subunit II; TIGRFAM: cytochrome d ubiquinol oxidase, subunit II; PFAM: cytochrome bd ubiquinol oxidase subunit II. (377 aa)
Tint_0291PFAM: cytochrome B561; KEGG: lch:Lcho_3536 cytochrome b561. (225 aa)
Tint_0606PFAM: FAD linked oxidase domain protein; KEGG: vap:Vapar_0222 FAD linked oxidase domain protein. (497 aa)
Tint_0614Hypothetical protein; PFAM: NADH/Ubiquinone/plastoquinone (complex I); NADH-Ubiquinone oxidoreductase (complex I) chain 5/L domain protein; KEGG: afe:Lferr_1359 NADH/ubiquinone/plastoquinone (complex I). (543 aa)
Tint_0626PFAM: FAD linked oxidase domain protein; KEGG: mpt:Mpe_A3774 putative oxidoreductase. (468 aa)
Tint_0634KEGG: maq:Maqu_0377 cytochrome b561. (220 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (401 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (298 aa)
Tint_0889Electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone. (561 aa)
Tint_0900PFAM: cyclase/dehydrase; KEGG: pna:Pnap_2004 cyclase/dehydrase. (146 aa)
Tint_0942PFAM: Methyltransferase type 11; KEGG: ajs:Ajs_2354 methyltransferase type 11. (232 aa)
Tint_1070KEGG: rpf:Rpic12D_1197 cytochrome c oxidase, cbb3-type, subunit I; TIGRFAM: cytochrome c oxidase, cbb3-type, subunit I; PFAM: cytochrome c oxidase subunit I; Belongs to the heme-copper respiratory oxidase family. (480 aa)
Tint_1073Cytochrome c oxidase, cbb3-type, subunit III; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. (314 aa)
Tint_1111KEGG: tgr:Tgr7_0684 hypothetical protein. (414 aa)
Tint_1304PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; KEGG: bph:Bphy_6214 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1018 aa)
Tint_1305PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: vap:Vapar_3814 4Fe-4S ferredoxin iron-sulfur binding domain protein. (275 aa)
Tint_1306PFAM: DMSO reductase anchor subunit (DmsC); KEGG: bur:Bcep18194_B1999 DMSO reductase anchor subunit (DmsC). (310 aa)
Tint_1344TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; KEGG: reu:Reut_A2047 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component. (950 aa)
Tint_13452-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (432 aa)
Tint_1359PFAM: FAD linked oxidase domain protein; KEGG: mpt:Mpe_A1420 putative oxidoreductase protein. (476 aa)
Tint_1393TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: cti:RALTA_A2531 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (416 aa)
Tint_1461PFAM: cytochrome c oxidase subunit I; KEGG: ttj:TTHA1135 ba3-type cytochrome c oxidase polypeptide I; Belongs to the heme-copper respiratory oxidase family. (567 aa)
ubiEHypothetical protein; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (249 aa)
nuoNHypothetical protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (488 aa)
Tint_2256Hypothetical protein; KEGG: mpt:Mpe_A1415 NADH dehydrogenase (quinone); TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain M; PFAM: NADH/Ubiquinone/plastoquinone (complex I). (494 aa)
Tint_2257Hypothetical protein; KEGG: mpt:Mpe_A1414 NADH dehydrogenase (quinone); TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain L; PFAM: NADH/Ubiquinone/plastoquinone (complex I); NADH-Ubiquinone oxidoreductase (complex I) chain 5/L domain protein. (676 aa)
nuoKHypothetical protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (104 aa)
nuoIHypothetical protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (162 aa)
nuoHRespiratory-chain NADH dehydrogenase subunit 1; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (353 aa)
Tint_2262Hypothetical protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (816 aa)
Tint_2264Hypothetical protein; KEGG: mms:mma_1466 NADH dehydrogenase subunit E; TIGRFAM: NADH-quinone oxidoreductase, E subunit; PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit. (179 aa)
Tint_2275PFAM: metallophosphoesterase; KEGG: mpt:Mpe_A3701 calcineurin-like phosphoesterase. (255 aa)
Tint_2333PFAM: Methyltransferase type 11; KEGG: afr:AFE_0623 methyltransferase, UbiE/COQ5 family. (254 aa)
Tint_2335KEGG: mpt:Mpe_A2165 type II citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (437 aa)
Tint_2337KEGG: bbr:BB3679 succinate dehydrogenase iron-sulfur subunit; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
Tint_2338KEGG: bur:Bcep18194_B2150 succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (587 aa)
Tint_2339KEGG: bte:BTH_II0661 succinate dehydrogenase, hydrophobic membrane anchor protein; TIGRFAM: succinate dehydrogenase, hydrophobic membrane anchor protein; PFAM: succinate dehydrogenase cytochrome b subunit. (121 aa)
Tint_2340KEGG: mpt:Mpe_A2170 succinate dehydrogenase subunit C; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: succinate dehydrogenase cytochrome b subunit. (137 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
Tint_2344TIGRFAM: 2-methylcitrate synthase/citrate synthase II; KEGG: reu:Reut_A2329 methylcitrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family. (387 aa)
Tint_2347Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (911 aa)
Tint_2478TIGRFAM: nitrate reductase, beta subunit; KEGG: dia:Dtpsy_0428 nitrate reductase, beta subunit. (507 aa)
Tint_2591PFAM: cytochrome c oxidase subunit III; KEGG: bph:Bphy_0281 cytochrome c oxidase subunit III. (286 aa)
Tint_2593Cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (543 aa)
Tint_2604PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; KEGG: reu:Reut_A3000 molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (695 aa)
Tint_2639KEGG: maq:Maqu_0377 cytochrome b561. (229 aa)
Tint_2645PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: lch:Lcho_1816 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (158 aa)
Tint_2692PFAM: cytochrome B561; KEGG: bxe:Bxe_B2745 putative cytochrome b561. (177 aa)
aceK(Isocitrate dehydrogenase (NADP(+))) kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (604 aa)
Tint_2796TIGRFAM: malate synthase A; KEGG: rpf:Rpic12D_1302 malate synthase A; PFAM: Malate synthase family protein; Belongs to the malate synthase family. (528 aa)
Tint_2957TIGRFAM: formate dehydrogenase, gamma subunit; KEGG: bpe:BP1475 formate dehydrogenase subunit C precursor. (394 aa)
Tint_2959PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: vap:Vapar_4061 4Fe-4S ferredoxin iron-sulfur binding domain protein. (210 aa)
Tint_3054PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: vha:VIBHAR_02586 hypothetical protein. (311 aa)
Tint_3055PFAM: Polysulphide reductase NrfD; KEGG: vha:VIBHAR_02585 hypothetical protein. (392 aa)
Tint_3056PFAM: molydopterin dinucleotide-binding region; molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; KEGG: vha:VIBHAR_02584 hypothetical protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1024 aa)
Tint_3075KEGG: avn:Avin_50570 Ni/Fe-hydrogenase, b-type cytochrome subunit, HoxZ; TIGRFAM: Ni/Fe-hydrogenase, b-type cytochrome subunit; PFAM: cytochrome B561. (239 aa)
Tint_3076PFAM: nickel-dependent hydrogenase large subunit; KEGG: azc:AZC_0599 hydrogenase large subunit protein; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (605 aa)
Tint_3077TIGRFAM: hydrogenase (NiFe) small subunit HydA; KEGG: mpt:Mpe_A2827 hydrogenase (acceptor); PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit. (370 aa)
Tint_3084KEGG: mgm:Mmc1_2497 Ni,Fe-hydrogenase I large subunit. (370 aa)
Tint_3089Hypothetical protein; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; KEGG: azc:AZC_0595 HupU protein. (333 aa)
Tint_3090PFAM: nickel-dependent hydrogenase large subunit; KEGG: azo:azo3808 ferredoxin hydrogenase, large subunit. (479 aa)
Tint_1699PFAM: respiratory-chain NADH dehydrogenase subunit 1; KEGG: hna:Hneap_1793 respiratory-chain NADH dehydrogenase subunit 1. (314 aa)
Tint_1700KEGG: hna:Hneap_1792 hydrogenase 4 membrane component (E). (226 aa)
Tint_1701Hypothetical protein; PFAM: NADH/Ubiquinone/plastoquinone (complex I); KEGG: hna:Hneap_1791 NADH/ubiquinone/plastoquinone (complex I). (485 aa)
Tint_1702Hypothetical protein; PFAM: NADH-ubiquinone oxidoreductase chain 49kDa; NADH dehydrogenase (ubiquinone) 30 kDa subunit; KEGG: hna:Hneap_1790 NADH dehydrogenase (ubiquinone) 30 kDa subunit. (532 aa)
Tint_1704Hypothetical protein; PFAM: NADH/Ubiquinone/plastoquinone (complex I); KEGG: hna:Hneap_1788 NADH/ubiquinone/plastoquinone (complex I). (667 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (944 aa)
Tint_2193Cytochrome b/b6 domain protein; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (467 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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