STRINGSTRING
argA argA Tint_0178 Tint_0178 metXS metXS dapF dapF argG argG Tint_2218 Tint_2218 Tint_2154 Tint_2154 Tint_2153 Tint_2153 Tint_0933 Tint_0933 Tint_0994 Tint_0994 Tint_1003 Tint_1003 selD selD Tint_1132 Tint_1132 thrB thrB Tint_1386 Tint_1386 trpB trpB Tint_1419 Tint_1419 ilvD ilvD ilvD-2 ilvD-2 serS serS Tint_1667 Tint_1667 Tint_1691 Tint_1691 carB carB carA carA dapE dapE dapD dapD Tint_1752 Tint_1752 Tint_1833 Tint_1833 cmk cmk Tint_1868 Tint_1868 Tint_1870 Tint_1870 trpC trpC trpD trpD trpE trpE serC serC argH argH proB proB Tint_2244 Tint_2244 folD folD metZ metZ trpA trpA trpB-2 trpB-2 Tint_0725 Tint_0725 glyA glyA lysA lysA Tint_0597 Tint_0597 Tint_0585 Tint_0585 argJ argJ Tint_0427 Tint_0427 trpF trpF asd asd leuB leuB leuD leuD leuC leuC Tint_2512 Tint_2512 Tint_2655 Tint_2655 ilvE ilvE proC proC argB argB dapA dapA argD argD ilvC ilvC Tint_2149 Tint_2149 Tint_2112 Tint_2112 Tint_2111 Tint_2111 Tint_2006 Tint_2006 Tint_1987 Tint_1987 dapB dapB Tint_2807 Tint_2807 ilvA ilvA proA proA metE metE Tint_3027 Tint_3027 argC argC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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argAKEGG: vap:Vapar_2722 amino-acid N-acetyltransferase; TIGRFAM: amino-acid N-acetyltransferase; PFAM: aspartate/glutamate/uridylate kinase; GCN5-related N-acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily. (441 aa)
Tint_0178Glutamate--putrescine ligase; KEGG: mpt:Mpe_A1901 L-glutamine synthetase; PFAM: glutamine synthetase catalytic region. (459 aa)
metXSHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (380 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (287 aa)
argGTIGRFAM: argininosuccinate synthase; KEGG: dia:Dtpsy_2233 argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (446 aa)
Tint_2218TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: dia:Dtpsy_0599 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (285 aa)
Tint_2154KEGG: lch:Lcho_2893 acetolactate synthase 3 catalytic subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. (596 aa)
Tint_2153KEGG: dac:Daci_4866 acetolactate synthase 3 regulatory subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (163 aa)
Tint_0933Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (311 aa)
Tint_0994TIGRFAM: serine O-acetyltransferase; KEGG: mpt:Mpe_A2839 serine O-acetyltransferase. (255 aa)
Tint_1003TIGRFAM: phenylalanine-4-hydroxylase; KEGG: mpt:Mpe_A0347 phenylalanine 4-monooxygenase; PFAM: Aromatic amino acid hydroxylase-like. (288 aa)
selDSelenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (358 aa)
Tint_1132TIGRFAM: tartrate dehydrogenase; KEGG: vei:Veis_2698 tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (367 aa)
thrBTIGRFAM: homoserine kinase; KEGG: aav:Aave_1928 homoserine kinase; PFAM: aminoglycoside phosphotransferase; Belongs to the pseudomonas-type ThrB family. (313 aa)
Tint_1386Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (165 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (400 aa)
Tint_1419KEGG: vap:Vapar_1632 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (471 aa)
ilvDTIGRFAM: dihydroxy-acid dehydratase; KEGG: pol:Bpro_2052 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (561 aa)
ilvD-2TIGRFAM: dihydroxy-acid dehydratase; KEGG: aeh:Mlg_0418 dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (613 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa)
Tint_1667KEGG: tgr:Tgr7_2387 asparagine synthase (glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. (638 aa)
Tint_1691TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); KEGG: rme:Rmet_1368 phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase. (293 aa)
carBKEGG: pol:Bpro_2678 carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Belongs to the CarB family. (1074 aa)
carAKEGG: mpt:Mpe_A1261 carbamoyl-phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (383 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (382 aa)
dapDTIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; KEGG: mpt:Mpe_A1806 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (273 aa)
Tint_1752KEGG: aav:Aave_2485 succinyldiaminopimelate transaminase; TIGRFAM: succinyldiaminopimelate transaminase; PFAM: aminotransferase class I and II. (403 aa)
Tint_1833KEGG: lch:Lcho_0664 cysteine synthase B; TIGRFAM: cysteine synthase B; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa)
cmk3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. (658 aa)
Tint_1868PFAM: Prephenate dehydrogenase; KEGG: vap:Vapar_1616 prephenate dehydrogenase. (304 aa)
Tint_1870KEGG: pol:Bpro_1792 chorismate mutase / prephenate dehydratase; TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein. (365 aa)
trpCKEGG: lch:Lcho_3876 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (290 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (499 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (367 aa)
argHKEGG: bur:Bcep18194_A5760 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (466 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (375 aa)
Tint_2244PFAM: peptidase dimerisation domain protein; peptidase M20; KEGG: mpt:Mpe_A0775 hypothetical protein. (415 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (404 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (292 aa)
trpB-2Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa)
Tint_0725Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1352 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa)
Tint_0597Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (367 aa)
Tint_0585MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (264 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (411 aa)
Tint_0427Aspartate kinase; KEGG: bpr:GBP346_A2661 asparate kinase, monofunctional class; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (417 aa)
trpFKEGG: lch:Lcho_1681 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (220 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (378 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (215 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
Tint_2512KEGG: vap:Vapar_4079 isocitrate dehydrogenase (NAD(+)); PFAM: isocitrate/isopropylmalate dehydrogenase. (343 aa)
Tint_2655KEGG: syg:sync_0178 asparagine synthase (glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. (600 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (311 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (286 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (304 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (300 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferase; KEGG: mpt:Mpe_A3029 acetylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
Tint_2149PFAM: transferase hexapeptide repeat containing protein; KEGG: mma:MM_3269 serine O-acetyltransferase. (188 aa)
Tint_2112KEGG: mpt:Mpe_A1541 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein. (436 aa)
Tint_2111TIGRFAM: threonine synthase; KEGG: mpt:Mpe_A1542 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (480 aa)
Tint_2006KEGG: spe:Spro_1379 GCN5-related N-acetyltransferase; manually curated; PFAM: GCN5-related N-acetyltransferase. (176 aa)
Tint_1987PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: bac:BamMC406_4343 serine/threonine dehydratase. (331 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
Tint_2807Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (910 aa)
ilvAThreonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (516 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (430 aa)
metE5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (793 aa)
Tint_3027TIGRFAM: asparagine synthase family amidotransferase; asparagine synthase (glutamine-hydrolyzing); KEGG: rfr:Rfer_3652 asparagine synthase, glutamine-hydrolyzing; PFAM: asparagine synthase; glutamine amidotransferase class-II. (597 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (352 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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