STRINGSTRING
Tint_0092 Tint_0092 apt apt cysC cysC Tint_0317 Tint_0317 prs prs surE surE Tint_0408 Tint_0408 Tint_0486 Tint_0486 Tint_0525 Tint_0525 Tint_0526 Tint_0526 purT purT Tint_0669 Tint_0669 Tint_0710 Tint_0710 purC purC purE purE purK purK Tint_0807 Tint_0807 purD purD Tint_0944 Tint_0944 Tint_0945 Tint_0945 Tint_0959 Tint_0959 purM purM amn amn guaC guaC Tint_1095 Tint_1095 Tint_1369 Tint_1369 purL purL Tint_1625 Tint_1625 Tint_1631 Tint_1631 Tint_1634 Tint_1634 Tint_1635 Tint_1635 Tint_1671 Tint_1671 adk adk Tint_1714 Tint_1714 guaA guaA guaB guaB purA purA ndk ndk Tint_2191 Tint_2191 ppnP ppnP Tint_2240 Tint_2240 Tint_2253 Tint_2253 purF purF purN purN Tint_2663 Tint_2663 gmk gmk Tint_2670 Tint_2670 purH purH Tint_2767 Tint_2767
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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Tint_0092TIGRFAM: adenylosuccinate lyase; KEGG: bcm:Bcenmc03_0633 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (467 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa)
cysCSulfate adenylyltransferase, large subunit; Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family. (609 aa)
Tint_0317KEGG: afr:AFE_2970 sulfate adenylyltransferase subunit 2; TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase. (299 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
surEStationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (251 aa)
Tint_0408PFAM: PfkB domain protein; KEGG: ajs:Ajs_3635 ribokinase-like domain-containing protein. (314 aa)
Tint_0486Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (811 aa)
Tint_0525Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (978 aa)
Tint_0526Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (402 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (401 aa)
Tint_0669TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: bbr:BB0073 deoxyguanosinetriphosphate triphosphohydrolase-like protein; SMART: metal-dependent phosphohydrolase HD region; Belongs to the dGTPase family. Type 2 subfamily. (379 aa)
Tint_0710KEGG: azo:azo1538 putative phosphoenolpyruvate-protein phosphotransferase; PFAM: GAF domain protein; pyridoxamine 5'-phosphate oxidase-related FMN-binding; SMART: GAF domain protein. (449 aa)
purCTIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: mpt:Mpe_A0292 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (294 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (389 aa)
Tint_0807TIGRFAM: pyruvate kinase; KEGG: mpt:Mpe_A0290 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (477 aa)
purDTIGRFAM: phosphoribosylamine/glycine ligase; KEGG: mpt:Mpe_A1338 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (427 aa)
Tint_0944Bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (284 aa)
Tint_0945Phosphoglucomutase; KEGG: rme:Rmet_2716 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase. (458 aa)
Tint_09595'-nucleotidase; KEGG: xom:XOO_4073 putative 5'-nucleotidase; PFAM: 5-nucleotidase. (315 aa)
purMTIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: vap:Vapar_1465 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (347 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (505 aa)
guaCGuanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (325 aa)
Tint_1095PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; KEGG: similar to phosphoglucomutase 1. (543 aa)
Tint_1369(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (738 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1335 aa)
Tint_1625Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (349 aa)
Tint_1631Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (446 aa)
Tint_1634Xanthine dehydrogenase, small subunit; KEGG: acr:Acry_1155 molybdopterin dehydrogenase, FAD-binding; TIGRFAM: xanthine dehydrogenase, small subunit; PFAM: molybdopterin dehydrogenase FAD-binding; [2Fe-2S]-binding domain protein; CO dehydrogenase flavoprotein domain protein. (530 aa)
Tint_1635TIGRFAM: xanthine dehydrogenase, molybdopterin binding subunit; KEGG: mpt:Mpe_A0798 xanthine oxidase; PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead. (836 aa)
Tint_1671KEGG: mpt:Mpe_A2492 adenylate cyclase; PFAM: Forkhead-associated protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: Forkhead-associated protein; adenylyl cyclase class-3/4/guanylyl cyclase. (306 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa)
Tint_1714KEGG: bmj:BMULJ_01231 exopolyphosphatase; PFAM: Ppx/GppA phosphatase. (511 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (532 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (440 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
Tint_2191Pyruvate kinase; KEGG: app:CAP2UW1_1860 pyruvate kinase; PFAM: Pyruvate kinase barrel. (620 aa)
ppnPProtein of unknown function DUF1255; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (108 aa)
Tint_2240TIGRFAM: hydroxyisourate hydrolase; KEGG: bvi:Bcep1808_1883 transthyretin; PFAM: Transthyretin; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (120 aa)
Tint_2253PFAM: NUDIX hydrolase; KEGG: har:HEAR1811 ADP-ribose pyrophosphatase. (199 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (500 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (207 aa)
Tint_2663(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (791 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa)
Tint_2670Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (255 aa)
purHSMART: AICARFT/IMPCHase bienzyme formylation region; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: tbd:Tbd_2458 IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. (516 aa)
Tint_27675'-nucleotidase; KEGG: pne:Pnec_1606 5'-nucleotidase; PFAM: 5-nucleotidase. (304 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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