STRINGSTRING
Tint_0057 Tint_0057 Tint_0224 Tint_0224 Tint_0427 Tint_0427 Tint_0484 Tint_0484 glyA glyA Tint_0731 Tint_0731 gpmA gpmA thrB thrB Tint_1298 Tint_1298 Tint_1346 Tint_1346 trpB trpB Tint_1619 Tint_1619 Tint_1691 Tint_1691 Tint_1808 Tint_1808 serC serC Tint_2111 Tint_2111 Tint_2112 Tint_2112 Tint_2150 Tint_2150 Tint_2305 Tint_2305 trpA trpA trpB-2 trpB-2 asd asd Tint_2569 Tint_2569 Tint_2570 Tint_2570 gcvP gcvP gcvH gcvH Tint_2573 Tint_2573 Tint_2718 Tint_2718 ilvA ilvA Tint_2855 Tint_2855 Tint_3193 Tint_3193
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tint_0057KEGG: pca:Pcar_1486 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (467 aa)
Tint_0224PFAM: Phosphoglycerate mutase; KEGG: pol:Bpro_4091 phosphoglycerate mutase. (216 aa)
Tint_0427Aspartate kinase; KEGG: bpr:GBP346_A2661 asparate kinase, monofunctional class; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (417 aa)
Tint_0484PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: vei:Veis_2069 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (328 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
Tint_0731Choline dehydrogenase; KEGG: dia:Dtpsy_0243 glucose-methanol-choline oxidoreductase; PFAM: glucose-methanol-choline oxidoreductase; GMC oxidoreductase. (561 aa)
gpmAPhosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (235 aa)
thrBTIGRFAM: homoserine kinase; KEGG: aav:Aave_1928 homoserine kinase; PFAM: aminoglycoside phosphotransferase; Belongs to the pseudomonas-type ThrB family. (313 aa)
Tint_1298PFAM: glucose-methanol-choline oxidoreductase; GMC oxidoreductase; KEGG: maq:Maqu_0437 glucose-methanol-choline oxidoreductase. (528 aa)
Tint_1346KEGG: bpt:Bpet1834 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (477 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (400 aa)
Tint_1619Rieske (2Fe-2S) iron-sulfur domain protein; PFAM: Rieske [2Fe-2S] iron-sulphur domain; KEGG: mpt:Mpe_A2634 putative dioxygenase (alpha subunit) oxidoreductase protein. (368 aa)
Tint_1691TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); KEGG: rme:Rmet_1368 phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase. (293 aa)
Tint_1808PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: afo:Afer_0293 pyridine nucleotide-disulphide oxidoreductase dimerization region. (475 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (367 aa)
Tint_2111TIGRFAM: threonine synthase; KEGG: mpt:Mpe_A1542 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (480 aa)
Tint_2112KEGG: mpt:Mpe_A1541 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein. (436 aa)
Tint_2150KEGG: mpt:Mpe_A2102 CDP-diacylglycerol--serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (297 aa)
Tint_2305KEGG: vap:Vapar_2165 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; biotin/lipoyl attachment domain-containing protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (603 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (292 aa)
trpB-2Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (378 aa)
Tint_2569TIGRFAM: L-serine dehydratase 1; KEGG: mpt:Mpe_A1429 L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (476 aa)
Tint_2570Threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (356 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa)
Tint_2573KEGG: aav:Aave_3145 glycine cleavage system T protein; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel. (386 aa)
Tint_2718PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: bgl:bglu_1g32580 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (316 aa)
ilvAThreonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (516 aa)
Tint_2855KEGG: ajs:Ajs_1122 hydroxypyruvate reductase; PFAM: MOFRL domain protein. (435 aa)
Tint_3193PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: dia:Dtpsy_1729 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding. (336 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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