STRINGSTRING
Tint_0004 Tint_0004 Tint_0005 Tint_0005 Tint_0009 Tint_0009 Tint_0057 Tint_0057 cbbL cbbL cbbS cbbS Tint_0139 Tint_0139 Tint_0178 Tint_0178 purU purU Tint_0484 Tint_0484 Tint_0604 Tint_0604 Tint_0605 Tint_0605 Tint_0606 Tint_0606 glyA glyA Tint_0943 Tint_0943 kynB kynB Tint_1132 Tint_1132 Tint_1316 Tint_1316 Tint_1317 Tint_1317 Tint_1346 Tint_1346 Tint_1382 Tint_1382 Tint_1594 Tint_1594 cbbM cbbM Tint_1808 Tint_1808 acsA acsA Tint_2305 Tint_2305 Tint_2335 Tint_2335 mdh mdh Tint_2347 Tint_2347 Tint_2353 Tint_2353 Tint_2354 Tint_2354 Tint_2404 Tint_2404 gcvP gcvP gcvH gcvH Tint_2573 Tint_2573 Tint_2718 Tint_2718 Tint_2730 Tint_2730 Tint_2796 Tint_2796 Tint_2855 Tint_2855 Tint_2856 Tint_2856 Tint_2857 Tint_2857 Tint_2858 Tint_2858 Tint_2957 Tint_2957 Tint_2959 Tint_2959 Tint_2960 Tint_2960 gph gph
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tint_0004PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; NADH dehydrogenase (ubiquinone) 24 kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; KEGG: vap:Vapar_4073 respiratory-chain NADH dehydrogenase domain 51 kDa subunit. (626 aa)
Tint_0005KEGG: vap:Vapar_4072 formate dehydrogenase, alpha subunit; TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molydopterin dinucleotide-binding region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (977 aa)
Tint_0009TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; KEGG: cvi:CV_0143 2-dehydro-3-deoxy-phosphogluconate aldolase; PFAM: KDPG and KHG aldolase. (207 aa)
Tint_0057KEGG: pca:Pcar_1486 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (467 aa)
cbbLRibulose-bisphosphate carboxylase; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type I subfamily. (473 aa)
cbbSKEGG: nwi:Nwi_1986 ribulose bisphosphate carboxylase, small chain; PFAM: ribulose bisphosphate carboxylase small chain. (109 aa)
Tint_0139KEGG: pna:Pnap_1985 phosphoglycolate phosphatase; TIGRFAM: phosphoglycolate phosphatase; HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase. (231 aa)
Tint_0178Glutamate--putrescine ligase; KEGG: mpt:Mpe_A1901 L-glutamine synthetase; PFAM: glutamine synthetase catalytic region. (459 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (291 aa)
Tint_0484PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: vei:Veis_2069 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (328 aa)
Tint_0604PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: mpt:Mpe_A3640 glycolate oxidase iron-sulfur subunit. (410 aa)
Tint_0605PFAM: FAD linked oxidase domain protein; KEGG: azo:azo1000 glycolate oxidase FAD binding subunit. (374 aa)
Tint_0606PFAM: FAD linked oxidase domain protein; KEGG: vap:Vapar_0222 FAD linked oxidase domain protein. (497 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
Tint_0943PFAM: AMP-dependent synthetase and ligase; KEGG: app:CAP2UW1_2247 AMP-dependent synthetase and ligase. (573 aa)
kynBArylformamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. (212 aa)
Tint_1132TIGRFAM: tartrate dehydrogenase; KEGG: vei:Veis_2698 tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (367 aa)
Tint_1316KEGG: rso:RSc1632 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
Tint_1317KEGG: cti:RALTA_A1352 acetyacetyl-CoA reductase; TIGRFAM: acetoacetyl-CoA reductase; PFAM: short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
Tint_1346KEGG: bpt:Bpet1834 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (477 aa)
Tint_1382KEGG: bph:Bphy_1368 isocitrate lyase; TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase. (435 aa)
Tint_1594KEGG: bph:Bphy_1030 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
cbbMRibulose-bisphosphate carboxylase; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type II subfamily. (461 aa)
Tint_1808PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: afo:Afer_0293 pyridine nucleotide-disulphide oxidoreductase dimerization region. (475 aa)
acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (659 aa)
Tint_2305KEGG: vap:Vapar_2165 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; biotin/lipoyl attachment domain-containing protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (603 aa)
Tint_2335KEGG: mpt:Mpe_A2165 type II citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (437 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
Tint_2347Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (911 aa)
Tint_2353KEGG: rso:RSc2429 oxidoreductase protein; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. (297 aa)
Tint_2354Arylformamidase; KEGG: pol:Bpro_1716 hypothetical protein; PFAM: Alpha/beta hydrolase fold-3 domain protein. (307 aa)
Tint_2404KEGG: bpy:Bphyt_2920 HAD-superfamily hydrolase, subfamily IA, variant 1; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase. (219 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa)
Tint_2573KEGG: aav:Aave_3145 glycine cleavage system T protein; TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel. (386 aa)
Tint_2718PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: bgl:bglu_1g32580 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (316 aa)
Tint_2730KEGG: mpt:Mpe_A3367 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
Tint_2796TIGRFAM: malate synthase A; KEGG: rpf:Rpic12D_1302 malate synthase A; PFAM: Malate synthase family protein; Belongs to the malate synthase family. (528 aa)
Tint_2855KEGG: ajs:Ajs_1122 hydroxypyruvate reductase; PFAM: MOFRL domain protein. (435 aa)
Tint_2856TIGRFAM: 2-hydroxy-3-oxopropionate reductase; KEGG: har:HEAR0334 tartronic semialdehyde reductase; PFAM: 6-phosphogluconate dehydrogenase NAD-binding. (296 aa)
Tint_2857TIGRFAM: hydroxypyruvate isomerase; KEGG: pol:Bpro_4562 hydroxypyruvate isomerase; PFAM: Xylose isomerase domain protein TIM barrel; Belongs to the hyi family. (257 aa)
Tint_2858KEGG: bcj:BCAL1949 glyoxylate carboligase; TIGRFAM: glyoxylate carboligase; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; Belongs to the TPP enzyme family. (582 aa)
Tint_2957TIGRFAM: formate dehydrogenase, gamma subunit; KEGG: bpe:BP1475 formate dehydrogenase subunit C precursor. (394 aa)
Tint_2959PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: vap:Vapar_4061 4Fe-4S ferredoxin iron-sulfur binding domain protein. (210 aa)
Tint_2960Nitrate reductase; KEGG: mpt:Mpe_A1170 formate dehydrogenase large subunit precursor; PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (995 aa)
gphPhosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (233 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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