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Tint_0051 Tint_0051 Tint_0053 Tint_0053 Tint_0069 Tint_0069 yajC yajC Tint_0171 Tint_0171 Tint_0172 Tint_0172 Tint_0173 Tint_0173 Tint_0174 Tint_0174 Tint_0175 Tint_0175 Tint_0334 Tint_0334 Tint_0338 Tint_0338 secA secA ffh ffh Tint_0603 Tint_0603 Tint_0679 Tint_0679 Tint_0726 Tint_0726 secB secB ftsY ftsY Tint_0772 Tint_0772 Tint_0773 Tint_0773 Tint_0774 Tint_0774 Tint_0775 Tint_0775 Tint_0776 Tint_0776 Tint_0841 Tint_0841 Tint_0844 Tint_0844 Tint_0845 Tint_0845 Tint_0846 Tint_0846 Tint_0847 Tint_0847 Tint_0848 Tint_0848 Tint_0849 Tint_0849 Tint_0850 Tint_0850 Tint_0902 Tint_0902 Tint_0903 Tint_0903 Tint_0904 Tint_0904 Tint_0905 Tint_0905 Tint_0906 Tint_0906 Tint_0916 Tint_0916 Tint_0917 Tint_0917 Tint_0918 Tint_0918 Tint_0919 Tint_0919 Tint_0920 Tint_0920 Tint_1417 Tint_1417 Tint_1490 Tint_1490 Tint_1564 Tint_1564 Tint_1565 Tint_1565 Tint_1566 Tint_1566 Tint_1567 Tint_1567 Tint_1568 Tint_1568 hfq hfq Tint_1935 Tint_1935 Tint_1936 Tint_1936 Tint_1937 Tint_1937 Tint_1959 Tint_1959 Tint_1960 Tint_1960 Tint_1962 Tint_1962 Tint_1968 Tint_1968 Tint_1969 Tint_1969 Tint_1971 Tint_1971 Tint_1972 Tint_1972 Tint_1974 Tint_1974 Tint_1994 Tint_1994 Tint_2269 Tint_2269 Tint_2409 Tint_2409 Tint_2410 Tint_2410 Tint_2411 Tint_2411 Tint_2412 Tint_2412 Tint_2416 Tint_2416 Tint_2424 Tint_2424 Tint_2518 Tint_2518 Tint_2576 Tint_2576 secY secY Tint_2680 Tint_2680 Tint_2706 Tint_2706 Tint_2710 Tint_2710 Tint_2784 Tint_2784 Tint_2800 Tint_2800 Tint_2861 Tint_2861 Tint_2988 Tint_2988 Tint_2989 Tint_2989 Tint_2990 Tint_2990 Tint_2991 Tint_2991 Tint_2992 Tint_2992 secE secE Tint_3116 Tint_3116 trpE trpE Tint_3187 Tint_3187 Tint_3188 Tint_3188 Tint_3189 Tint_3189 Tint_3190 Tint_3190 Tint_3191 Tint_3191 yidC yidC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tint_0051KEGG: tbd:Tbd_2771 two component Fis family transcriptional regulator; PFAM: sigma-54 factor interaction domain-containing protein; response regulator receiver; helix-turn-helix Fis-type; SMART: response regulator receiver; AAA ATPase. (456 aa)
Tint_0053Integral membrane sensor signal transduction histidine kinase; Manually curated; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: nmu:Nmul_A1159 periplasmic sensor signal transduction histidine kinase; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (487 aa)
Tint_0069Two component transcriptional regulator, winged helix family; KEGG: pna:Pnap_3600 two component transcriptional regulator; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver. (231 aa)
yajCPreprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (111 aa)
Tint_0171PFAM: Extracellular ligand-binding receptor; Twin-arginine translocation pathway, signal sequence, subgroup; KEGG: acr:Acry_1052 extracellular ligand-binding receptor. (420 aa)
Tint_0172PFAM: inner-membrane translocator; KEGG: acr:Acry_1051 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (289 aa)
Tint_0173PFAM: inner-membrane translocator; KEGG: acr:Acry_3458 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (331 aa)
Tint_0174KEGG: acr:Acry_1049 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (249 aa)
Tint_0175KEGG: acr:Acry_1048 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (236 aa)
Tint_0334Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (361 aa)
Tint_0338Putative transcriptional regulator, Crp/Fnr family; KEGG: aav:Aave_0636 cyclic nucleotide-binding protein; PFAM: cyclic nucleotide-binding; SMART: cyclic nucleotide-binding. (212 aa)
secAPreprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (929 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (449 aa)
Tint_0603PFAM: Extracellular ligand-binding receptor; KEGG: rpf:Rpic12D_2746 extracellular ligand-binding receptor. (378 aa)
Tint_0679KEGG: vap:Vapar_2384 two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver. (258 aa)
Tint_0726Putative transcriptional regulator, Crp/Fnr family; KEGG: aeh:Mlg_1182 cyclic nucleotide-binding protein; PFAM: cyclic nucleotide-binding; SMART: cyclic nucleotide-binding. (157 aa)
secBProtein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (164 aa)
ftsYSignal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (368 aa)
Tint_0772PFAM: inner-membrane translocator; KEGG: reh:H16_A3658 ABC-type transporter, permease component; Belongs to the binding-protein-dependent transport system permease family. (326 aa)
Tint_0773PFAM: inner-membrane translocator; KEGG: bbr:BB3789 putative branched-chain amino acid transport permease; Belongs to the binding-protein-dependent transport system permease family. (295 aa)
Tint_0774PFAM: Extracellular ligand-binding receptor; KEGG: bur:Bcep18194_A3267 branched chain amino acid ABC transporter periplasmic ligand-binding protein. (398 aa)
Tint_0775KEGG: dac:Daci_5163 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (259 aa)
Tint_0776KEGG: reh:H16_A3662 ABC transporter ATPase; PFAM: ABC transporter related; SMART: AAA ATPase. (255 aa)
Tint_0841Transcriptional regulator, Crp/Fnr family; KEGG: bbr:BB0234 cyclic nucleotide-binding protein; PFAM: cyclic nucleotide-binding; SMART: regulatory protein Crp. (279 aa)
Tint_0844KEGG: app:CAP2UW1_1616 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (276 aa)
Tint_0845KEGG: lch:Lcho_3438 hypothetical protein. (447 aa)
Tint_0846PFAM: inner-membrane translocator; KEGG: pna:Pnap_3610 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (354 aa)
Tint_0847PFAM: inner-membrane translocator; KEGG: pna:Pnap_3609 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (298 aa)
Tint_0848KEGG: aav:Aave_0786 ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase. (281 aa)
Tint_0849PFAM: AMP-dependent synthetase and ligase; KEGG: aav:Aave_0787 AMP-dependent synthetase and ligase. (651 aa)
Tint_0850KEGG: vap:Vapar_5005 transcriptional regulator, Crp/Fnr family; PFAM: cyclic nucleotide-binding; SMART: cyclic nucleotide-binding. (239 aa)
Tint_0902KEGG: mms:mma_1553 amino-acid ATP-binding ABC transporter protein; PFAM: ABC transporter related; SMART: AAA ATPase. (240 aa)
Tint_0903KEGG: bxe:Bxe_A1320 branched chain amino acid ABC transporter ATPase; PFAM: ABC transporter related; SMART: AAA ATPase. (256 aa)
Tint_0904PFAM: inner-membrane translocator; KEGG: mpt:Mpe_A1772 putative amino acid transport system permease lipoprotein transmembrane. (414 aa)
Tint_0905PFAM: inner-membrane translocator; KEGG: pol:Bpro_2577 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (324 aa)
Tint_0906KEGG: rfr:Rfer_2392 extracellular ligand-binding receptor. (440 aa)
Tint_0916KEGG: acr:Acry_2201 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (241 aa)
Tint_0917KEGG: acr:Acry_2202 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (238 aa)
Tint_0918PFAM: inner-membrane translocator; KEGG: acr:Acry_2203 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (296 aa)
Tint_0919PFAM: inner-membrane translocator; KEGG: acr:Acry_2204 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (293 aa)
Tint_0920PFAM: Extracellular ligand-binding receptor; KEGG: acr:Acry_2205 extracellular ligand-binding receptor. (415 aa)
Tint_1417PFAM: AMP-dependent synthetase and ligase; KEGG: sme:SM_b20650 putative long-chain fatty-acid-CoA ligase protein. (515 aa)
Tint_1490PFAM: cyclic nucleotide-binding; KEGG: hna:Hneap_1873 putative transcriptional regulator, Crp/Fnr family. (166 aa)
Tint_1564PFAM: Extracellular ligand-binding receptor; KEGG: cti:RALTA_B1759 high-affinity branched-chain amino acid transport protein, ligand-binding receptor. (390 aa)
Tint_1565KEGG: rme:Rmet_3977 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (245 aa)
Tint_1566KEGG: dac:Daci_0262 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (254 aa)
Tint_1567PFAM: inner-membrane translocator; KEGG: dac:Daci_0261 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (344 aa)
Tint_1568PFAM: inner-membrane translocator; KEGG: reu:Reut_B3660 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (289 aa)
hfqRNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (81 aa)
Tint_1935PFAM: conjugation TrbI family protein; KEGG: pna:Pnap_2511 conjugation TrbI family protein. (469 aa)
Tint_1936PFAM: Conjugal transfer protein TrbG/VirB9/CagX; KEGG: pna:Pnap_2510 conjugal transfer protein TrbG/VirB9/CagX. (322 aa)
Tint_1937PFAM: Conjugal transfer protein; KEGG: pna:Pnap_2509 conjugal transfer protein. (216 aa)
Tint_1959PFAM: conjugation TrbI family protein; KEGG: pna:Pnap_2511 conjugation TrbI family protein. (460 aa)
Tint_1960PFAM: Conjugal transfer protein TrbG/VirB9/CagX; KEGG: pna:Pnap_2510 conjugal transfer protein TrbG/VirB9/CagX. (327 aa)
Tint_1962PFAM: Conjugal transfer protein; KEGG: pna:Pnap_2509 conjugal transfer protein. (216 aa)
Tint_1968P-type conjugative transfer protein TrbL; KEGG: pna:Pnap_2505 type IV secretory pathway TrbL components-like protein; TIGRFAM: P-type conjugative transfer protein TrbL; PFAM: TrbL/VirB6 plasmid conjugal transfer protein. (576 aa)
Tint_1969TIGRFAM: P-type conjugative transfer protein TrbJ; KEGG: pna:Pnap_2504 conjugal transfer protein TrbJ. (232 aa)
Tint_1971KEGG: pna:Pnap_2503 CagE, TrbE, VirB component of type IV transporter system; PFAM: CagE, TrbE, VirB component of type IV transporter system, conserved region; SMART: AAA ATPase. (816 aa)
Tint_1972PFAM: Conjugal transfer TrbD family protein; KEGG: pna:Pnap_2502 conjugal transfer TrbD family protein. (99 aa)
Tint_1974PFAM: Conjugal transfer protein TrbC; KEGG: pna:Pnap_2501 conjugal transfer protein TrbC. (117 aa)
Tint_1994P-type conjugative transfer ATPase TrbB; KEGG: pna:Pnap_2497 type II secretion system protein E; TIGRFAM: P-type conjugative transfer ATPase TrbB; PFAM: type II secretion system protein E; DEAD/DEAH box helicase domain protein. (316 aa)
Tint_2269Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (141 aa)
Tint_2409ABC transporter related protein; KEGG: mpt:Mpe_A1126 putative amino acid ATP-binding ABC transporter protein; PFAM: ABC transporter related; SMART: AAA ATPase. (237 aa)
Tint_2410KEGG: dac:Daci_5352 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (256 aa)
Tint_2411PFAM: inner-membrane translocator; KEGG: aav:Aave_1876 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (373 aa)
Tint_2412PFAM: inner-membrane translocator; KEGG: rfr:Rfer_3172 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (310 aa)
Tint_2416Transcriptional regulator, Crp/Fnr family; KEGG: mpt:Mpe_A1119 catabolite gene activator (cAMP receptor protein) (cAMP-regulatory protein); PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp. (223 aa)
Tint_2424Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (366 aa)
Tint_2518PFAM: AMP-dependent synthetase and ligase; KEGG: vap:Vapar_0394 AMP-dependent synthetase and ligase. (556 aa)
Tint_2576PFAM: Extracellular ligand-binding receptor; KEGG: pna:Pnap_2166 extracellular ligand-binding receptor. (378 aa)
secYPreprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (439 aa)
Tint_2680Two component transcriptional regulator, winged helix family; KEGG: pna:Pnap_3958 two component transcriptional regulator; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver. (239 aa)
Tint_2706PFAM: phosphoesterase; KEGG: bpy:Bphyt_4267 phosphoesterase. (582 aa)
Tint_2710PFAM: Extracellular ligand-binding receptor; KEGG: pna:Pnap_2166 extracellular ligand-binding receptor. (382 aa)
Tint_2784Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (371 aa)
Tint_2800KEGG: hna:Hneap_0554 ferric uptake regulator, Fur family; manually curated; PFAM: ferric-uptake regulator; Belongs to the Fur family. (152 aa)
Tint_2861Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (376 aa)
Tint_2988KEGG: dac:Daci_0575 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (271 aa)
Tint_2989KEGG: app:CAP2UW1_4466 ABC transporter related; PFAM: ABC transporter related; inner-membrane translocator; SMART: AAA ATPase; Belongs to the binding-protein-dependent transport system permease family. (592 aa)
Tint_2990PFAM: inner-membrane translocator; KEGG: eba:ebA3558 putative branched-chain amino acid transport system permease protein. (346 aa)
Tint_2991PFAM: Extracellular ligand-binding receptor; KEGG: bpy:Bphyt_3910 extracellular ligand-binding receptor. (387 aa)
Tint_2992PFAM: Extracellular ligand-binding receptor; KEGG: azo:azo0311 ABC transporter substrate-binding protein. (383 aa)
secEPreprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (127 aa)
Tint_3116KEGG: mms:mma_0234 anthranilate synthase component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I. (196 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (499 aa)
Tint_3187KEGG: acr:Acry_0356 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (233 aa)
Tint_3188KEGG: acr:Acry_0357 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase. (271 aa)
Tint_3189PFAM: inner-membrane translocator; KEGG: acr:Acry_0358 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (311 aa)
Tint_3190PFAM: inner-membrane translocator; KEGG: acr:Acry_0359 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family. (301 aa)
Tint_3191PFAM: Extracellular ligand-binding receptor; KEGG: acr:Acry_0360 extracellular ligand-binding receptor. (380 aa)
yidCMembrane protein insertase, YidC/Oxa1 family domain containing protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (565 aa)
Your Current Organism:
Thiomonas intermedia
NCBI taxonomy Id: 75379
Other names: T. intermedia K12, Thiobacillus intermedius K12, Thiomonas intermedia K12, Thiomonas intermedia str. K12, Thiomonas intermedia strain K12
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