STRINGSTRING
hisB hisB hisH hisH hisA hisA hisF hisF hisE hisE AGB43172.1 AGB43172.1 AGB43668.1 AGB43668.1 AGB43957.1 AGB43957.1 hisC hisC AGB44496.1 AGB44496.1 hisD hisD hisZ hisZ hisG hisG AGB45296.1 AGB45296.1 AGB45360.1 AGB45360.1 AGB45658.1 AGB45658.1 hisI hisI hutU hutU AGB46925.1 AGB46925.1 hutH hutH hutI hutI AGB46928.1 AGB46928.1 AGB47219.1 AGB47219.1 AGB47713.1 AGB47713.1 hisD-2 hisD-2 AGB48070.1 AGB48070.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hisBPFAM: Imidazoleglycerol-phosphate dehydratase. (199 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa)
hisAPFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (249 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (263 aa)
hisEPFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase. (107 aa)
AGB43172.1PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (790 aa)
AGB43668.1PFAM: Phenylalanine and histidine ammonia-lyase. (606 aa)
AGB43957.1Monoamine oxidase; PFAM: Flavin containing amine oxidoreductase. (436 aa)
hisCPFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (369 aa)
AGB44496.1PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (504 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
hisZATP phosphoribosyltransferase involved in histidine biosynthesis; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (372 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (232 aa)
AGB45296.1PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (498 aa)
AGB45360.1PFAM: Aldehyde dehydrogenase family. (477 aa)
AGB45658.1PFAM: Phenylalanine and histidine ammonia-lyase. (505 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (153 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (556 aa)
AGB46925.1PFAM: N-formylglutamate amidohydrolase; TIGRFAM: N-formylglutamate amidohydrolase. (272 aa)
hutHPFAM: Phenylalanine and histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase. (513 aa)
hutIImidazolonepropionase; PFAM: Amidohydrolase family; TIGRFAM: imidazolonepropionase. (411 aa)
AGB46928.1PFAM: Amidohydrolase family; TIGRFAM: formiminoglutamate deiminase. (451 aa)
AGB47219.1PLP-dependent enzyme, histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. (370 aa)
AGB47713.1PFAM: Phenylalanine and histidine ammonia-lyase. (498 aa)
hisD-2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa)
AGB48070.1PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (484 aa)
Your Current Organism:
Mesorhizobium australicum
NCBI taxonomy Id: 754035
Other names: M. australicum WSM2073, Mesorhizobium australicum LMG 24608, Mesorhizobium australicum WSM2073, Mesorhizobium australicum str. WSM2073, Mesorhizobium australicum strain WSM2073, Mesorhizobium sp. WSM 2073, Mesorhizobium sp. WSM2073
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