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| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (334 aa) |
| | PPA1976 | Para-aminobenzoate synthase. (579 aa) |
| | pheA | Prephenate dehydratase; L-Arogenate <=> L-Phenylalanine + H2O + CO2 and Prephenate <=> Phenylpyruvate + H2O + CO2. (328 aa) |
| | argG | Argininosuccinate synthase; ATP + L-Citrulline + L-Aspartate <=> AMP + Pyrophosphate + N-(L-Arginino)succinate; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (478 aa) |
| | aroE | Shikimate + NADP+ <=> 3-Dehydroshikimate + NADPH + H+ and Shikimate + NADP+ <=> 5-Dehydroshikimate + NADPH. (272 aa) |
| | CBL55697.1 | 6 Protein of unknown function, without similarity to other proteins. (543 aa) |
| | CBL55700.1 | (S)-Dihydroorotate + Oxygen <=> Orotate + H2O2. (385 aa) |
| | folP1 | Dihydropteroate synthase; 2-Amino-4-hydroxy-6-hydroxymethyl-7, 8-dihydropteridine + 4-Aminobenzoate <=> Dihydropteroate + H2O / 2-Amino-7, 8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine + 4-Aminobenzoate <=> Pyrophosphate + Dihydropteroate. (296 aa) |
| | pabA | Glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase; Chorismate + NH3 <=> Anthranilate + Pyruvate + H2O Chorismate + L-Glutamine <=> Anthranilate + Pyruvate + L-Glutamate. (214 aa) |
| | serA | 3-Phosphoglycerate + NAD+ <=> 3-Phosphonooxypyruvate + NADH + H+ glycine, serine, threonine metabolism. (349 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (424 aa) |
| | ask | Aspartokinase (Aspartate kinase); ATP + L-Aspartate <=> ADP + 4-Phospho-L-aspartate; Belongs to the aspartokinase family. (424 aa) |
| | purD | Phosphoribosylamine-glycine ligase; ATP + 5-Phosphoribosylamine + Glycine <=> ADP + Orthophosphate + 5prime-Phosphoribosylglycinamide; Belongs to the GARS family. (443 aa) |
| | purB | Adenylosuccinate lyase; N6-(1,2-Dicarboxyethyl)-AMP <=> Fumarate + AMP 1-(5prime-Phosphoribosyl)-5-amino-4-(N- succinocarboxamide)-imidazole These proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Catalyzes the seventh step of the de novo biosynthesis of purine nucleotides, the conversion of carboximideaminoimidazole ribonucleotide (CAIR) into succinoaminoimidazolecarboximide ribonucleotide (SAICAR). CAIR and aspartic acid react in the presence of ATP and magnesium to form SAICAR. (292 aa) |
| | purS | Phosphoribosylformylglycinamidine synthetase PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...] (81 aa) |
| | purL/purQ | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (225 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II (FGAM synthase II); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is [...] (754 aa) |
| | fhs | Formate--tetrahydrofolate ligase; ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate; Belongs to the formate--tetrahydrofolate ligase family. (558 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (513 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (353 aa) |
| | guaB1 | Inosine-5-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD) / GMP reductase); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (506 aa) |
| | guaB2 | Inosine-5-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD) / GMP reductase. (367 aa) |
| | CBL56181.1 | Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine. (109 aa) |
| | cysE | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. (183 aa) |
| | cys1 | Cysteine synthase 1; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | purN | 5-phosphoribosylglycinamide formyltransferase (phosphoribosylglycinamide formyltransferase); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (203 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase); 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide and IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide. (517 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (Bifunctional protein); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | CBL56239.1 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (335 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (393 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (186 aa) |
| | clpS | ATP-dependent Clp protease adaptor protein clpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (103 aa) |
| | CBL56288.1 | 5.2 Protein of unknown function similar to proteins from other organisms. (201 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (272 aa) |
| | rph | Ribonuclease PH (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (253 aa) |
| | CBL56291.1 | HAM1, NTPase/HAM1; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (268 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (270 aa) |
| | folA | Dihydrofolate reductase; 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH. tetrahydrofolate biosynthesis; tetrahydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 3/3. (209 aa) |
| | ligA | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (764 aa) |
| | thrC | Threonine synthase (O-phospho-L-homoserine phosphate-lyase (adding water;L-threonine-forming)); O-Phospho-L-homoserine + H2O <=> L-Threonine + Orthophosphate / O-Phospho-4-hydroxy-L-threonine + H2O <=> 4-Hydroxy-L-threonine + Orthophosphate. (480 aa) |
| | folC | Folylpolyglutamate synthase (bifunctionnal enzyme); ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + Tetrahydrofolyl-[Glu](2). (501 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (158 aa) |
| | pyrC | Dihydroorotase multifunctional complex type (dihydroorotase); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa) |
| | CBL56490.1 | 5.2 Protein of unknown function similar to proteins from other organisms; Belongs to the UPF0301 (AlgH) family. (188 aa) |
| | CBL56532.1 | D-3-phosphoglycerate dehydrogenase / erythronate 4-phosphate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (397 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (450 aa) |
| | lysA | Diaminopimelate decarboxylase (DAP decarboxylase); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (543 aa) |
| | thrA/hom | L-Homoserine + NAD+ <=> L-Aspartate 4-semialdehyde + NADH + H+ and L-Homoserine + NADP+ <=> L-Aspartate 4-semialdehyde + NADPH + H+. (441 aa) |
| | serB/thrH | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; O-Phospho-L-serine + H2O <=> L-Serine + Orthophosphate and D-O-Phosphoserine + H2O <=> D-Serine + Orthophosphate. (207 aa) |
| | metE | Methionine synthase, vitamin-B12 independent; 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine. (328 aa) |
| | luxS | S-ribosylhomocysteine lyase (Autoinducer-2 production protein luxS) (AI-2 synthesis protein); Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (154 aa) |
| | tyrA | Prephenate + NAD+ <=> 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADH + H+. (364 aa) |
| | metH | Methionine synthase (5-methyltetrahydrofolate:L-homocysteine S-methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1163 aa) |
| | CBL56660.1 | Sun, tRNA and rRNA cytosine-C5-methylases; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (439 aa) |
| | fmt | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (315 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (673 aa) |
| | gmk | Guanylate kinase, Guanosine monophosphate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | pyrF | Orotidine 5-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Orotidine 5 prime-phosphate <=> UMP + CO2. (269 aa) |
| | pyrD | Dihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (366 aa) |
| | carB | Carbamoyl-phosphate synthase large chain (Carbamoyl-phosphate synthetase ammonia chain); 2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate; Binds 3 manganese ions per subunit; Belongs to the CarB family. (1113 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; The product carbamoyl phosphate is an intermediate in the biosynthesis of arginine and the pyrimidine nucleotides; Belongs to the CarA family. (394 aa) |
| | aroB | 3-dehydroquinate synthase / shikimate kinase, bifunctionnal enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (549 aa) |
| | aroF | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (400 aa) |
| | relA | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (783 aa) |
| | apt | Adenine phosphoribosyltransferase (AMP:diphosphate phospho-D-ribosyltransferase); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (179 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)- 1-(5-phosphoribosyl)imidazole-4-carboxamide. (241 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (225 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase (IGPD). (202 aa) |
| | hisC | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (407 aa) |
| | hisD | Histidinol dehydrogenase (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa) |
| | CBL56702.1 | 5.2 Protein of unknown function similar to proteins from other organisms. (254 aa) |
| | ybaK/EbsC | YbaC/EbsC protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (172 aa) |
| | lgt | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (323 aa) |
| | trpA | Tryptophan synthase alpha chain (TrpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (298 aa) |
| | trpB | Tryptophan synthase beta chain (TrpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa) |
| | trpC | Indole-3-glycerol phosphate synthase (TrpC); 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O; Belongs to the TrpC family. (286 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (510 aa) |
| | hisI2 | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (144 aa) |
| | CBL56715.1 | 5.2 Protein of unknown function similar to proteins from other organisms. (230 aa) |
| | cysK | Cysteine synthase (O-acetylserine sulfhydrylase); O3-acetyl-L-serine + H2S = L-cysteine + acetate. COFACTOR: Pyridoxal phosphate Belongs to the cysteine synthase/cystathionine beta-synthase family. (324 aa) |
| | nrdJ | Vitamin B12-dependent ribonucleotide reductase (Ribonucleoside-diphosphate reductase NrdJ); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (963 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (277 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | argH | Argininosuccinate lyase (Arginosuccinase); N-(L-Arginino)succinate <=> Fumarate + L-Arginine. (452 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (184 aa) |
| | argD | Acetylornithine and succinylornithine aminotransferase (ACOAT); N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. cofactor : Pyridoxal phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (407 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (303 aa) |
| | ArgJ | Arginine biosynthesis bifunctional protein ArgJ alpha chain; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (287 aa) |
| | hisE | Phosphoribosyl-ATP + H2O <=> Phosphoribosyl-AMP + Pyrophosphate; Belongs to the PRA-PH family. (88 aa) |
| | trpB2 | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (496 aa) |
| | dapB | Dihydrodipicolinate reductase (DHPR); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (246 aa) |
| | ribF | Riboflavin biosynthesis protein (Riboflavin kinase) FAD synthetase; ATP + FMN <=> Pyrophosphate + FAD / ATP + Riboflavin <=> ADP + FMN; Belongs to the ribF family. (325 aa) |
| | metF | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H; Belongs to the methylenetetrahydrofolate reductase family. (313 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa) |
| | guaB3 | Inosine-5-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD) / GMP reductase; IMP + NAD+ + H2O <=> Xanthosine 5prime-phosphate + NADH + H+. (487 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (281 aa) |
| | CBL57118.1 | 5.2 Protein of unknown function similar to proteins from other organisms. (55 aa) |
| | CBL57119.1 | Hypothetical membrane protein. (130 aa) |
| | CBL57121.1 | Possible lysine decarboxylase. The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes proteins annotated as lysine decarboxylases, although the evidence for this is not clear; Belongs to the LOG family. (280 aa) |
| | dapE2 | Succinyl-diaminopimelate desuccinylase; N-Succinyl-LL-2,6-diaminoheptanedioate + H2O <=> Succinate + LL-2,6-Diaminoheptanedioate. (362 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (312 aa) |
| | CBL57124.1 | Hypothetical secreted protein. (281 aa) |
| | CBL57125.1 | Aminotransferase; Molecular function: transaminase activity. (363 aa) |
| | fdxA | Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (106 aa) |
| | cys2 | Cysteine synthase 2; Formation of cysteine from O-acetyl-serine and hydrogen sulfide. O3-acetyl-L-serine + H2S = L-cysteine + acetate; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa) |
| | CBL57243.1 | MazG-family transcriptional regulator. (223 aa) |
| | pyrB | Carbamoyl phosphate + L-Aspartate <=> Orthophosphate + N-Carbamoyl-L-aspartate; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (348 aa) |
| | rutG | Pyrimidine permease RutG (Pyrimidine utilization protein G). (516 aa) |
| | serC | Phosphoserine aminotransferase (phosphoserine transaminase); Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (373 aa) |
| | CBL57325.1 | Permease. (520 aa) |
| | sdaA | L-serine dehydratase (L-serine ammonia-lyase); L-Serine <=> Pyruvate + NH3 / alpha-Amino acid <=> 2-Oxo acid + NH3 L-Serine <=> 2-Aminoacrylate + H2O /; Belongs to the iron-sulfur dependent L-serine dehydratase family. (470 aa) |
| | metB | Cystathionine gamma-synthase (O-succinylhomoserine (thiol)-lyase). (395 aa) |
| | glyA | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (482 aa) |
| | pyrE | Orotate phosphoribosyltransferase (OPRT) (OPRTase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (185 aa) |
| | purA | Adenylosuccinate synthetase (IMP--aspartate ligase) (AdSS) (AMPSase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase (Semialdehyde dehydrogenase); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | folK | Putative hydroxymethyldihydropteridine pyrophosphokinase. (181 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (124 aa) |
| | folP2 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (288 aa) |
| | folE | Catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate. (225 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (140 aa) |
| | ribAB | GTP cyclohydrolase II protein, Riboflavin biosynthesis protein; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (489 aa) |
| | ribC | Riboflavin synthase alpha chain; 2 6,7-Dimethyl-8-(1-D-ribityl)lumazine <=> Riboflavin + 4-(1-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine. (220 aa) |
| | ribD | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (406 aa) |
| | cysA | Sulfate/thiosulfate import ATP-binding protein CysA (Sulfate-transporting ATPase); Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (350 aa) |
| | cysW | Sulfate transport system permease protein CysW. (262 aa) |
| | cysT | Sulphate transport system permease protein 2:Sulfate ABC transporter, permease protein CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (354 aa) |
| | CBL57663.1 | Sulfate-binding protein precursor. (344 aa) |
| | nirA2/sir2 | Sulfite reductase [ferredoxin]; Hydrogen sulfide + 6 oxidized ferredoxin + 3 H2O = sulfite + 6 reduced ferredoxin + 6 H+.Binds 1 siroheme per subunit Binds 1 4Fe-4S cluster per subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (615 aa) |
| | cysH | Putative phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (260 aa) |
| | mmcV/cysD | ATP + sulfate = diphosphate + adenylyl sulfate. (355 aa) |
| | cysN | Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (449 aa) |
| | CBL57693.1 | Hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (359 aa) |
| | guA | Glutamine amidotransferase class-I; ATP + xanthosine 5 prime-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate; inhibiteur Psicofuranin. (229 aa) |
| | malY | Cysteine-S-conjugate beta-lyase; L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate. (397 aa) |
| | lacI4 | Transcriptional regulator, LacI family (HTH-type transcriptional regulator degA). (347 aa) |
| | sseB | Thiosulfate + Cyanide <=> Sulfite + Thiocyanate. (272 aa) |
| | CBL57890.1 | Xanthine/uracil permease. (659 aa) |
