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WPG_0034 WPG_0034 pyrD pyrD WPG_0071 WPG_0071 WPG_0117 WPG_0117 ribH ribH WPG_0362 WPG_0362 WPG_0367 WPG_0367 WPG_0421 WPG_0421 folE folE queE queE folD folD pyrE pyrE carA carA purK purK purE purE WPG_0617 WPG_0617 WPG_0622 WPG_0622 thyA thyA WPG_0772 WPG_0772 WPG_0823 WPG_0823 WPG_0837 WPG_0837 WPG_1037 WPG_1037 WPG_1077 WPG_1077 WPG_1115 WPG_1115 WPG_1212 WPG_1212 WPG_1215 WPG_1215 WPG_1225 WPG_1225 tdk tdk WPG_1259 WPG_1259 WPG_1317 WPG_1317 purD purD WPG_1362 WPG_1362 dut dut WPG_1674 WPG_1674 WPG_1829 WPG_1829 WPG_1887 WPG_1887 purH purH WPG_2358 WPG_2358 WPG_2456 WPG_2456 purL purL WPG_2596 WPG_2596 WPG_2614 WPG_2614 fmt fmt folE-2 folE-2 ribB ribB purC purC WPG_2912 WPG_2912 pyrB pyrB WPG_2997 WPG_2997 WPG_3061 WPG_3061 WPG_3229 WPG_3229 WPG_3513 WPG_3513 WPG_3514 WPG_3514 WPG_3522 WPG_3522
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WPG_0034Phosphoribosyltransferase. (167 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (346 aa)
WPG_0071Transcription termination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (300 aa)
WPG_0117Uridine kinase. (211 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (168 aa)
WPG_0362Orotidine 5'-phosphate decarboxylase. (271 aa)
WPG_0367Phosphoribosylformylglycinamidine cyclo-ligase. (392 aa)
WPG_0421Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (275 aa)
folEGTP cyclohydrolase I. (225 aa)
queEQueuosine Biosynthesis QueE Radical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (210 aa)
folDMethylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (367 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (384 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (152 aa)
WPG_0617Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (168 aa)
WPG_0622Dihydrofolate synthase. (390 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (274 aa)
WPG_0772Dihydrofolate reductase. (310 aa)
WPG_0823ATP-grasp enzyme-like protein. (316 aa)
WPG_08372-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (379 aa)
WPG_1037dCMP deaminase. (143 aa)
WPG_1077Riboflavin kinase; Belongs to the ribF family. (298 aa)
WPG_1115Hypothetical protein. (170 aa)
WPG_1212Phosphoribosylglycinamide formyltransferase. (188 aa)
WPG_1215Amidophosphoribosyltransferase. (632 aa)
WPG_1225Queuosine biosynthesis QueD, PTPS-I. (150 aa)
tdkThymidine kinase. (215 aa)
WPG_1259Riboflavin synthase eubacterial/eukaryotic. (196 aa)
WPG_1317Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (125 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa)
WPG_1362Phosphoribosyltransferase. (219 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
WPG_1674Dihydroorotase. (448 aa)
WPG_1829Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (270 aa)
WPG_1887Phosphoribulokinase/uridine kinase. (208 aa)
purHIMP cyclohydrolase. (522 aa)
WPG_2358Hypothetical protein. (274 aa)
WPG_24566-pyruvoyl tetrahydrobiopterin synthase. (136 aa)
purLPhosphoribosylformylglycinamidine synthase, synthetase subunit; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1218 aa)
WPG_2596Carbamoyl-phosphate synthase large chain. (951 aa)
WPG_2614Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (447 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (319 aa)
folE-2GTP cyclohydrolase I. (230 aa)
ribB3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (382 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (316 aa)
WPG_2912Uracil phosphoribosyltransferase. (179 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (309 aa)
WPG_2997Dihydroorotase. (417 aa)
WPG_3061Purine nucleoside phosphorylase. (290 aa)
WPG_3229ATP-grasp enzyme-like protein. (323 aa)
WPG_35135'-nucleotidase. (252 aa)
WPG_35145'-nucleotidase; Belongs to the 5'-nucleotidase family. (308 aa)
WPG_3522Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (334 aa)
Your Current Organism:
Winogradskyella sp. PG2
NCBI taxonomy Id: 754409
Other names: W. sp. PG-2, Winogradskyella sp. PG-2
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