STRINGSTRING
ndk ndk WPG_0034 WPG_0034 pyrD pyrD WPG_0117 WPG_0117 pyrG pyrG WPG_0362 WPG_0362 pyrE pyrE carA carA WPG_0617 WPG_0617 WPG_0753 WPG_0753 thyA thyA WPG_0823 WPG_0823 pyrH pyrH WPG_1023 WPG_1023 WPG_1024 WPG_1024 WPG_1037 WPG_1037 tdk tdk WPG_1362 WPG_1362 dut dut WPG_1674 WPG_1674 WPG_1829 WPG_1829 WPG_1887 WPG_1887 surE surE WPG_2596 WPG_2596 cmk cmk WPG_2912 WPG_2912 pyrB pyrB WPG_2997 WPG_2997 WPG_3061 WPG_3061 WPG_3229 WPG_3229 WPG_3514 WPG_3514
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
WPG_0034Phosphoribosyltransferase. (167 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (346 aa)
WPG_0117Uridine kinase. (211 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (538 aa)
WPG_0362Orotidine 5'-phosphate decarboxylase. (271 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (367 aa)
WPG_0617Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (168 aa)
WPG_0753Deoxyadenosine kinase. (204 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (274 aa)
WPG_0823ATP-grasp enzyme-like protein. (316 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa)
WPG_1023Ribonucleotide reductase of class Ia (aerobic), alpha subunit. (599 aa)
WPG_1024Ribonucleotide reductase of class Ia (aerobic), beta subunit. (429 aa)
WPG_1037dCMP deaminase. (143 aa)
tdkThymidine kinase. (215 aa)
WPG_1362Phosphoribosyltransferase. (219 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
WPG_1674Dihydroorotase. (448 aa)
WPG_1829Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (270 aa)
WPG_1887Phosphoribulokinase/uridine kinase. (208 aa)
surE5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa)
WPG_2596Carbamoyl-phosphate synthase large chain. (951 aa)
cmkCytidylate kinase. (229 aa)
WPG_2912Uracil phosphoribosyltransferase. (179 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (309 aa)
WPG_2997Dihydroorotase. (417 aa)
WPG_3061Purine nucleoside phosphorylase. (290 aa)
WPG_3229ATP-grasp enzyme-like protein. (323 aa)
WPG_35145'-nucleotidase; Belongs to the 5'-nucleotidase family. (308 aa)
Your Current Organism:
Winogradskyella sp. PG2
NCBI taxonomy Id: 754409
Other names: W. sp. PG-2, Winogradskyella sp. PG-2
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