STRINGSTRING
WPG_0011 WPG_0011 WPG_0042 WPG_0042 WPG_0119 WPG_0119 WPG_0121 WPG_0121 WPG_0170 WPG_0170 WPG_0232 WPG_0232 accA accA WPG_0251 WPG_0251 WPG_0253 WPG_0253 sucC sucC tpiA tpiA mdh mdh folD folD WPG_0509 WPG_0509 eno eno gcvP gcvP WPG_0615 WPG_0615 pdhA pdhA WPG_0682 WPG_0682 WPG_0765 WPG_0765 gcvH gcvH WPG_0898 WPG_0898 WPG_0992 WPG_0992 WPG_0993 WPG_0993 WPG_1042 WPG_1042 WPG_1052 WPG_1052 WPG_1054 WPG_1054 WPG_1065 WPG_1065 WPG_1068 WPG_1068 WPG_1074 WPG_1074 WPG_1087 WPG_1087 fbp fbp WPG_1167 WPG_1167 WPG_1168 WPG_1168 WPG_1169 WPG_1169 WPG_1207 WPG_1207 WPG_1253 WPG_1253 WPG_1254 WPG_1254 WPG_1262 WPG_1262 WPG_1268 WPG_1268 WPG_1282 WPG_1282 WPG_1283 WPG_1283 WPG_1307 WPG_1307 pgk pgk WPG_1448 WPG_1448 pgi pgi pckA pckA WPG_1854 WPG_1854 WPG_1870 WPG_1870 ilvA ilvA WPG_1979 WPG_1979 accD accD WPG_1990 WPG_1990 gpmI gpmI WPG_2061 WPG_2061 WPG_2505 WPG_2505 WPG_2559 WPG_2559 WPG_2774 WPG_2774 WPG_2775 WPG_2775 WPG_2888 WPG_2888 WPG_2954 WPG_2954 WPG_3012 WPG_3012 WPG_3014 WPG_3014 gcvT gcvT sucD sucD WPG_3222 WPG_3222 serC serC WPG_3259 WPG_3259 fumC fumC WPG_3304 WPG_3304 pfkA pfkA WPG_3316 WPG_3316 WPG_3403 WPG_3403 fabV fabV WPG_3438 WPG_3438 tal tal glyA glyA WPG_3489 WPG_3489
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WPG_0011NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (482 aa)
WPG_0042Aconitate hydratase. (755 aa)
WPG_0119methylmalonyl-CoA mutase. (460 aa)
WPG_0121methylmalonyl-CoA mutase. (707 aa)
WPG_0170Serine acetyltransferase. (197 aa)
WPG_0232Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (740 aa)
accAAcetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
WPG_0251Transketolase, N-terminal section. (281 aa)
WPG_0253Transketolase, C-terminal section. (317 aa)
sucCsuccinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (396 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (308 aa)
folDMethylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
WPG_0509Citrate synthase; Belongs to the citrate synthase family. (428 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (949 aa)
WPG_0615Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (538 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (318 aa)
WPG_06823-hydroxybutyryl-CoA dehydrogenase. (384 aa)
WPG_0765Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
WPG_0898NADP-dependent malic enzyme. (762 aa)
WPG_0992Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (404 aa)
WPG_09932-oxoglutarate dehydrogenase E1 component. (921 aa)
WPG_10425,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (327 aa)
WPG_10524-hydroxy-2-oxoglutarate aldolase. (222 aa)
WPG_10542-dehydro-3-deoxygluconate kinase. (295 aa)
WPG_10656-phosphogluconate dehydrogenase, decarboxylating; Belongs to the 6-phosphogluconate dehydrogenase family. (620 aa)
WPG_10682-dehydro-3-deoxygluconate kinase. (207 aa)
WPG_1074Ribose-phosphate pyrophosphokinase. (313 aa)
WPG_1087D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (325 aa)
fbpFructose-1,6-bisphosphatase, type I; Belongs to the FBPase class 1 family. (348 aa)
WPG_1167Succinate dehydrogenase iron-sulfur protein. (248 aa)
WPG_1168Succinate dehydrogenase flavoprotein subunit. (665 aa)
WPG_1169Succinate dehydrogenase cytochrome b subunit. (175 aa)
WPG_1207Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
WPG_1253Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
WPG_1254Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (160 aa)
WPG_1262Pyruvate-flavodoxin oxidoreductase. (651 aa)
WPG_1268Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (631 aa)
WPG_1282Gluconolactonase. (264 aa)
WPG_1283methylmalonyl-CoA epimerase. (134 aa)
WPG_1307Ribose 5-phosphate isomerase B. (144 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
WPG_1448enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (548 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (538 aa)
WPG_1854Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (835 aa)
WPG_1870Glyceraldehyde-3-phosphate dehydrogenase, putative. (530 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (426 aa)
WPG_1979Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
accDAcetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (285 aa)
WPG_1990Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (365 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
WPG_2061NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
WPG_2505Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (446 aa)
WPG_2559enoyl-CoA hydratase. (802 aa)
WPG_2774propionyl-CoA carboxylase beta chain. (513 aa)
WPG_2775Pyruvate carboxyl transferase subunit A; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (479 aa)
WPG_2888Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase. (458 aa)
WPG_2954Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa)
WPG_3012Iron-sulphur-binding reductase. (260 aa)
WPG_3014Phosphoserine phosphatase. (407 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
sucDsuccinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
WPG_3222Serine O-acetyltransferase. (193 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (353 aa)
WPG_3259D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
WPG_3304NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (328 aa)
WPG_3316acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
WPG_3403L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (474 aa)
fabVShort-chain alcohol dehydrogenase family; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (396 aa)
WPG_3438Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. (466 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
WPG_34893-hydroxybutyryl-CoA dehydrogenase. (296 aa)
Your Current Organism:
Winogradskyella sp. PG2
NCBI taxonomy Id: 754409
Other names: W. sp. PG-2, Winogradskyella sp. PG-2
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.