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| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (259 aa) |
| | WPG_0011 | NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (482 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | WPG_0042 | Aconitate hydratase. (755 aa) |
| | WPG_0126 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (233 aa) |
| | WPG_0170 | Serine acetyltransferase. (197 aa) |
| | WPG_0232 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (740 aa) |
| | WPG_0251 | Transketolase, N-terminal section. (281 aa) |
| | WPG_0253 | Transketolase, C-terminal section. (317 aa) |
| | WPG_0271 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (391 aa) |
| | WPG_0275 | Shikimate 5-dehydrogenase I alpha. (253 aa) |
| | WPG_0282 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (271 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (401 aa) |
| | WPG_0338 | Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (356 aa) |
| | WPG_0370 | Glutamine synthetase type III, GlnN. (728 aa) |
| | WPG_0371 | Glutamine synthetase type II, eukaryotic. (341 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | WPG_0460 | Asparagine synthetase. (553 aa) |
| | WPG_0509 | Citrate synthase; Belongs to the citrate synthase family. (428 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | WPG_0674 | Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (355 aa) |
| | aroA | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (407 aa) |
| | WPG_0722 | 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase I beta. (360 aa) |
| | WPG_0723 | Prephenate and/or arogenate dehydrogenase. (283 aa) |
| | WPG_0724 | Biosynthetic Aromatic amino acid aminotransferase alpha. (380 aa) |
| | WPG_0725 | Prephenate dehydratase. (275 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (417 aa) |
| | WPG_1039 | 5-methyltetrahydrofolate--homocysteine methyltransferase. (335 aa) |
| | WPG_1041 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (892 aa) |
| | WPG_1047 | 3-dehydroquinate synthase. (388 aa) |
| | WPG_1074 | Ribose-phosphate pyrophosphokinase. (313 aa) |
| | WPG_1087 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (325 aa) |
| | WPG_1099 | Aspartokinase; Belongs to the aspartokinase family. (416 aa) |
| | WPG_1207 | Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa) |
| | WPG_1307 | Ribose 5-phosphate isomerase B. (144 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa) |
| | WPG_1538 | Cystathionine gamma-lyase. (379 aa) |
| | WPG_1847 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (335 aa) |
| | WPG_1850 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (461 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (372 aa) |
| | WPG_1859 | Glutamate synthase [NADPH] large chain. (1504 aa) |
| | WPG_1860 | Glutamate synthase [NADPH] small chain. (487 aa) |
| | argH | Argininosuccinate lyase. (424 aa) |
| | WPG_1862 | Acetylornithine deacetylase. (353 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (258 aa) |
| | WPG_1865 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (375 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (325 aa) |
| | WPG_1868 | Argininosuccinate synthase. (394 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (426 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (500 aa) |
| | WPG_1873 | Acetolactate synthase small subunit. (176 aa) |
| | WPG_1874 | Acetolactate synthase large subunit. (578 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (559 aa) |
| | WPG_1979 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa) |
| | WPG_1990 | Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (365 aa) |
| | WPG_2000 | Aspartate aminotransferase. (376 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa) |
| | WPG_2061 | NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa) |
| | WPG_2072 | Aspartate aminotransferase. (396 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (255 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (211 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (261 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (330 aa) |
| | WPG_2269 | Anthranilate synthase, amidotransferase component. (188 aa) |
| | WPG_2270 | Anthranilate synthase, aminase component. (466 aa) |
| | WPG_2424 | Cystathionine beta-synthase. (326 aa) |
| | WPG_2670 | Aminodeoxychorismate lyase. (283 aa) |
| | WPG_2725 | Cystathionine gamma-lyase. (384 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (140 aa) |
| | WPG_2966 | L-allo-threonine aldolase. (339 aa) |
| | WPG_2973 | Cystathionine beta-synthase. (345 aa) |
| | WPG_3014 | Phosphoserine phosphatase. (407 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (199 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (247 aa) |
| | hisH | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (193 aa) |
| | hisB | Histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (377 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (344 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (304 aa) |
| | WPG_3222 | Serine O-acetyltransferase. (193 aa) |
| | WPG_3225 | Asparagine synthetase. (634 aa) |
| | WPG_3235 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (351 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (353 aa) |
| | WPG_3259 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa) |
| | WPG_3304 | NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (328 aa) |
| | WPG_3325 | Aspartokinase. (823 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa) |
| | WPG_3327 | Threonine synthase. (429 aa) |
| | WPG_3403 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (474 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
