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cysG cysG Q7A_160 Q7A_160 hemC hemC hemE hemE Q7A_2903 Q7A_2903 HemN HemN hemF hemF hemA hemA gltX gltX hemH hemH hemL hemL Q7A_996 Q7A_996
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query proteins and first shell of interactors
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second shell of interactors
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a 3D structure is known or predicted
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cysGSiroheme synthase / Uroporphyrinogen-III methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (464 aa)
Q7A_160Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (254 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa)
hemEUroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa)
Q7A_2903Porphobilinogen synthase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (336 aa)
HemNCoproporphyrinogen III oxidase; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
hemFCoproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (308 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (419 aa)
gltXGlutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (467 aa)
hemHFerrochelatase, protoheme ferro-lyase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (337 aa)
hemLPFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (428 aa)
Q7A_996PFAM: Uncharacterised protein family (UPF0093); TIGRFAM: TIGR00701 family protein. (141 aa)
Your Current Organism:
Methylophaga nitratireducenticrescens
NCBI taxonomy Id: 754476
Other names: ATCC BAA-2433, DSM 25689, M. nitratireducenticrescens, Methylophaga nitratireducenticrescens Villeneuve et al. 2013, Methylophaga sp. GP59, Methylophaga sp. JAM1, strain JAM1
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