STRINGSTRING
Q7A_1450 Q7A_1450 metZ metZ thrB thrB metK metK ahcY ahcY MetF MetF Q7A_2990 Q7A_2990 Q7A_3062 Q7A_3062 Q7A_3063 Q7A_3063 Q7A_3064 Q7A_3064 Q7A_3065 Q7A_3065 Q7A_3066 Q7A_3066 Q7A_3067 Q7A_3067 metE metE Q7A_889 Q7A_889
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Q7A_1450Methionine gamma-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme. (351 aa)
metZO-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (405 aa)
thrBHomoserine kinase; PFAM: Phosphotransferase enzyme family; TIGRFAM: homoserine kinase, Neisseria type; Belongs to the pseudomonas-type ThrB family. (318 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (387 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (436 aa)
MetFPFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. (283 aa)
Q7A_29905-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1232 aa)
Q7A_3062Hypothetical protein. (166 aa)
Q7A_3063Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (381 aa)
Q7A_3064PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; ACT domain. (436 aa)
Q7A_3065PFAM: Aminotransferase class I and II. (371 aa)
Q7A_3066Hypothetical protein. (39 aa)
Q7A_3067Putative signal transduction protein; PFAM: HDOD domain. (280 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (759 aa)
Q7A_889PFAM: Aminotransferase class I and II. (390 aa)
Your Current Organism:
Methylophaga nitratireducenticrescens
NCBI taxonomy Id: 754476
Other names: ATCC BAA-2433, DSM 25689, M. nitratireducenticrescens, Methylophaga nitratireducenticrescens Villeneuve et al. 2013, Methylophaga sp. GP59, Methylophaga sp. JAM1, strain JAM1
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