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Q7A_1823 Q7A_1823 rlmB rlmB ubiG ubiG pcm-3 pcm-3 Q7A_934 Q7A_934 pcm-2 pcm-2 Q7A_888 Q7A_888 Q7A_876 Q7A_876 Q7A_871 Q7A_871 Q7A_736 Q7A_736 Q7A_72 Q7A_72 MetW MetW rsmJ rsmJ Q7A_644 Q7A_644 Q7A_549 Q7A_549 trmL trmL Q7A_334 Q7A_334 metE metE pcm pcm Q7A_3081 Q7A_3081 rlmJ rlmJ bioC bioC EgtD EgtD Q7A_2990 Q7A_2990 rlmE rlmE Q7A_2782 Q7A_2782 cmoM cmoM rlmN rlmN Q7A_252 Q7A_252 Q7A_2504 Q7A_2504 Q7A_2451 Q7A_2451 prmC prmC Q7A_2424 Q7A_2424 Q7A_2391 Q7A_2391 Q7A_2385 Q7A_2385 ubiE ubiE rsmG rsmG rsmA rsmA trmB trmB Q7A_2156 Q7A_2156 Q7A_2142 Q7A_2142 Q7A_2082 Q7A_2082 Q7A_1968 Q7A_1968 Q7A_1952 Q7A_1952 Q7A_1927 Q7A_1927 rlmL rlmL Q7A_1858 Q7A_1858 Q7A_177 Q7A_177 Q7A_1754 Q7A_1754 Q7A_1681 Q7A_1681 Q7A_1658 Q7A_1658 Q7A_159 Q7A_159 Q7A_1563 Q7A_1563 cysG cysG Q7A_151 Q7A_151 trmJ trmJ Q7A_1437 Q7A_1437 rlmD rlmD prmA prmA rlmH rlmH RsmD RsmD thyA thyA trmD trmD rsmH rsmH rsmI rsmI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Q7A_1823Hypothetical protein; PFAM: Isoprenylcysteine carboxyl methyltransferase (ICMT) family. (219 aa)
rlmB23S rRNA (guanosine-2'-O-) -methyltransferase rlmB; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (242 aa)
ubiG3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (233 aa)
pcm-3Protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (251 aa)
Q7A_934PFAM: Methyltransferase domain. (214 aa)
pcm-2Protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (220 aa)
Q7A_888Hypothetical protein; PFAM: Formylglycine-generating sulfatase enzyme. (715 aa)
Q7A_876Mg-protoporphyrin IX monomethyl ester oxidative cyclase; PFAM: Radical SAM superfamily; B12 binding domain. (503 aa)
Q7A_871PFAM: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); TIGRFAM: protein-L-isoaspartate(D-aspartate) O-methyltransferase. (271 aa)
Q7A_736Type I restriction-modification system, DNA-methyltransferase subunit M; PFAM: N-6 DNA Methylase; HsdM N-terminal domain. (492 aa)
Q7A_72Methyltransferase type 12; PFAM: Tellurite resistance protein TehB. (191 aa)
MetWPFAM: Methionine biosynthesis protein MetW; TIGRFAM: methionine biosynthesis protein MetW. (200 aa)
rsmJSAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. (251 aa)
Q7A_644Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (289 aa)
Q7A_549PFAM: Methyltransferase domain. (241 aa)
trmLtRNA (cytosine34-2'-O-)-methyltransferase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (154 aa)
Q7A_334Hypothetical protein; PFAM: Uncharacterized ACR, COG1565. (387 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (759 aa)
pcmProtein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (684 aa)
Q7A_3081Farnesyl cysteine carboxyl-methyltransferase; PFAM: Isoprenylcysteine carboxyl methyltransferase (ICMT) family. (187 aa)
rlmJHypothetical protein; Specifically methylates the adenine in position 2030 of 23S rRNA. (278 aa)
bioCBiotin synthesis protein bioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (299 aa)
EgtDPutative methyltransferase; PFAM: Uncharacterized conserved protein (DUF2260); TIGRFAM: probable methyltransferase. (337 aa)
Q7A_29905-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1232 aa)
rlmECell division protein FtsJ / Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (205 aa)
Q7A_2782Type III restriction-modification system methylation subunit; PFAM: DNA methylase. (673 aa)
cmoMS-adenosylmethionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family. (255 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (368 aa)
Q7A_252Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (435 aa)
Q7A_2504Protein-N(5)-glutamine methyltransferase PrmB, methylates LSU ribosomal protein L3p; PFAM: Methyltransferase small domain; TIGRFAM: protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; HemK family putative methylases; Belongs to the protein N5-glutamine methyltransferase family. (320 aa)
Q7A_2451Ribosomal RNA small subunit methyltransferase E; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (242 aa)
prmCMethylase of polypeptide chain release factors; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (282 aa)
Q7A_2424PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain. (277 aa)
Q7A_2391Methyltransferase family protein; PFAM: C-methyltransferase; Hypothetical methyltransferase. (408 aa)
Q7A_2385Methyltransferase type 12; PFAM: Methyltransferase domain. (387 aa)
ubiEUbiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (248 aa)
rsmGrRNA small subunit methyltransferase; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (208 aa)
rsmADimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (264 aa)
trmBtRNA (guanine46-N7-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (228 aa)
Q7A_2156Type I restriction-modification system, DNA-methyltransferase subunit M; PFAM: N-6 DNA Methylase; HsdM N-terminal domain; TIGRFAM: type I restriction system adenine methylase (hsdM). (531 aa)
Q7A_2142ADA regulatory protein / Methylated-DNA--protein-cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain; TIGRFAM: O-6-methylguanine DNA methyltransferase. (179 aa)
Q7A_2082Methyl-directed repair DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase; TIGRFAM: DNA adenine methylase (dam). (261 aa)
Q7A_1968Type I restriction-modification system, DNA-methyltransferase subunit M; PFAM: N-6 DNA Methylase; HsdM N-terminal domain. (493 aa)
Q7A_1952PFAM: Methyltransferase domain. (229 aa)
Q7A_1927Putative methyltransferase. (199 aa)
rlmL23S rRNA (guanine-N-2-) -methyltransferase rlmL; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (744 aa)
Q7A_1858Hypothetical protein. (425 aa)
Q7A_177PFAM: Isoprenylcysteine carboxyl methyltransferase (ICMT) family. (231 aa)
Q7A_1754PFAM: Protein of unknown function (DUF2789). (64 aa)
Q7A_1681Fe-S oxidoreductase; PFAM: Domain of unknown function (DUF3362); Radical SAM superfamily; Radical SAM N-terminal; TIGRFAM: uncharacterized radical SAM protein YgiQ. (725 aa)
Q7A_1658PFAM: Protein of unknown function, DUF488. (103 aa)
Q7A_159Hypothetical protein; PFAM: HemX. (344 aa)
Q7A_1563Methyltransferase. (270 aa)
cysGSiroheme synthase / Uroporphyrinogen-III methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (464 aa)
Q7A_151Double-stranded RNA 3'-methylase; PFAM: Methyltransferase domain. (207 aa)
trmJtRNA:Cm32/Um32 methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (247 aa)
Q7A_1437PFAM: Methyltransferase domain. (278 aa)
rlmDRNA methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (442 aa)
prmARibosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (289 aa)
rlmHLSU m3Psi1915 methyltransferase; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (156 aa)
RsmDRibosomal RNA small subunit methyltransferase D; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family. (162 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa)
trmDtRNA (Guanine37-N1) -methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (247 aa)
rsmHrRNA small subunit methyltransferase H; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (312 aa)
rsmIrRNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (281 aa)
Your Current Organism:
Methylophaga nitratireducenticrescens
NCBI taxonomy Id: 754476
Other names: ATCC BAA-2433, DSM 25689, M. nitratireducenticrescens, Methylophaga nitratireducenticrescens Villeneuve et al. 2013, Methylophaga sp. GP59, Methylophaga sp. JAM1, strain JAM1
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