STRINGSTRING
Q7A_101 Q7A_101 deaD deaD Q7A_1153 Q7A_1153 Q7A_1154 Q7A_1154 xseB xseB Q7A_1216 Q7A_1216 Ggt Ggt bpt bpt pnp pnp dtd dtd GloA GloA Ald Ald Q7A_1599 Q7A_1599 Q7A_1600 Q7A_1600 csrA csrA Q7A_171 Q7A_171 Q7A_1780 Q7A_1780 Q7A_1792 Q7A_1792 Q7A_1799 Q7A_1799 Q7A_1889 Q7A_1889 Q7A_2079 Q7A_2079 Q7A_2088 Q7A_2088 Q7A_2144 Q7A_2144 edd edd rnhB rnhB Q7A_2279 Q7A_2279 Q7A_2419 Q7A_2419 Q7A_2420 Q7A_2420 Q7A_2467 Q7A_2467 anmK anmK gcvH gcvH Q7A_2588 Q7A_2588 Q7A_2732 Q7A_2732 EpmB EpmB ffsA ffsA Q7A_2860 Q7A_2860 rhlB rhlB Q7A_2927 Q7A_2927 rne rne slyX slyX rppH rppH Q7A_300 Q7A_300 Q7A_3014 Q7A_3014 Q7A_3057 Q7A_3057 rph rph RdgB RdgB Q7A_31 Q7A_31 Q7A_382 Q7A_382 Q7A_383 Q7A_383 Q7A_384 Q7A_384 Q7A_416 Q7A_416 mch mch Q7A_469 Q7A_469 gloB gloB rnhA rnhA Q7A_620 Q7A_620 mltF mltF Q7A_767 Q7A_767 Q7A_768 Q7A_768 xseA xseA Q7A_797 Q7A_797 Q7A_874 Q7A_874 surE surE Q7A_920 Q7A_920 Q7A_980 Q7A_980 Q7A_983 Q7A_983 Q7A_924 Q7A_924 Q7A_932 Q7A_932 mtaD mtaD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Q7A_101Hypothetical protein; PFAM: MOSC domain. (241 aa)
deaDCold-shock DEAD-box protein A; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (602 aa)
Q7A_1153Alpha/beta superfamily hydrolase. (254 aa)
Q7A_1154Putative pyrophosphatase; PFAM: MazG nucleotide pyrophosphohydrolase domain. (116 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (81 aa)
Q7A_1216PFAM: Helicase conserved C-terminal domain; DbpA RNA binding domain; DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (460 aa)
GgtPFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase. (556 aa)
bptArginine-tRNA-protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. Belongs to the R-transferase family. Bpt subfamily. (237 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (697 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (147 aa)
GloALactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
AldPFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: alanine dehydrogenase; Belongs to the AlaDH/PNT family. (373 aa)
Q7A_1599Deacylase; PFAM: Succinylglutamate desuccinylase / Aspartoacylase family. (351 aa)
Q7A_1600Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (649 aa)
csrACarbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa)
Q7A_171Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (691 aa)
Q7A_1780Dienelactone hydrolase-like enzyme; PFAM: Dienelactone hydrolase family. (242 aa)
Q7A_1792PFAM: Dienelactone hydrolase family. (247 aa)
Q7A_1799PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (282 aa)
Q7A_1889PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein. (136 aa)
Q7A_2079Oxygen-insensitive NAD(P)H nitroreductase / Dihydropteridine reductase; PFAM: Nitroreductase family. (216 aa)
Q7A_2088Hypothetical protein; PFAM: DoxX. (211 aa)
Q7A_2144PFAM: NADH:flavin oxidoreductase / NADH oxidase family. (342 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (607 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (190 aa)
Q7A_22792-hydroxy-3-oxopropionate reductase; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. (287 aa)
Q7A_2419Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (122 aa)
Q7A_2420Phosphopantothenoylcysteine decarboxylase / Phosphopantothenoylcysteine synthetase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (406 aa)
Q7A_2467Hypothetical protein. (96 aa)
anmKAnhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (375 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
Q7A_2588PFAM: Isochorismatase family. (200 aa)
Q7A_27322-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase. (330 aa)
EpmBLysyl-lysine 2,3-aminomutase; PFAM: Radical SAM superfamily; TIGRFAM: KamA family protein; lysine-2,3-aminomutase-related protein. (335 aa)
ffsAFormylmethanofuran--tetrahydromethanopterin N-formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family. (300 aa)
Q7A_2860PFAM: Heme oxygenase. (207 aa)
rhlBATP-dependent RNA helicase RhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (438 aa)
Q7A_2927ATP-dependent RNA helicase SrmB; PFAM: DEAD/DEAH box helicase. (298 aa)
rneRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (805 aa)
slyXHypothetical protein; PFAM: SlyX; Belongs to the SlyX family. (67 aa)
rppHAdenosine (5')-pentaphospho-(5'')-adenosine pyrophosphohydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (171 aa)
Q7A_300Hypothetical protein; PFAM: Scavenger mRNA decapping enzyme C-term binding. (112 aa)
Q7A_3014Putative streptogramin lyase. (315 aa)
Q7A_3057PFAM: YicC-like family, N-terminal region; Domain of unknown function (DUF1732); TIGRFAM: TIGR00255 family protein. (283 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa)
RdgBNucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (201 aa)
Q7A_31Phosphoserine phosphatase; TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490; Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like. (218 aa)
Q7A_382Isoquinoline 1-oxidoreductase alpha subunit; PFAM: 2Fe-2S iron-sulfur cluster binding domain; [2Fe-2S] binding domain. (154 aa)
Q7A_383Isoquinoline 1-oxidoreductase beta subunit; PFAM: Molybdopterin-binding domain of aldehyde dehydrogenase; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain. (772 aa)
Q7A_384Xanthine and CO dehydrogenases maturation factor; PFAM: XdhC and CoxI family. (331 aa)
Q7A_416PFAM: Catalase; Catalase-related immune-responsive; Belongs to the catalase family. (485 aa)
mchN(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (327 aa)
Q7A_469PFAM: SNO glutamine amidotransferase family; TIGRFAM: pyridoxal 5'-phosphate synthase, glutaminase subunit Pdx2. (188 aa)
gloBHydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (256 aa)
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase H family. (147 aa)
Q7A_620Zn-dependent hydrolase; PFAM: Metallo-beta-lactamase superfamily. (310 aa)
mltFTransglycosylase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (473 aa)
Q7A_7676-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (488 aa)
Q7A_768Hypothetical protein; PFAM: SdiA-regulated. (288 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (500 aa)
Q7A_797YoeB toxin protein; PFAM: Plasmid encoded toxin Txe; TIGRFAM: toxin-antitoxin system, toxin component, Txe/YoeB family. (87 aa)
Q7A_874PFAM: Isochorismatase family. (183 aa)
surE5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (239 aa)
Q7A_920Hypothetical protein. (41 aa)
Q7A_980Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (162 aa)
Q7A_983Hydrolase or acyltransferase. (296 aa)
Q7A_924YoeB toxin protein; PFAM: Plasmid encoded toxin Txe; TIGRFAM: toxin-antitoxin system, toxin component, Txe/YoeB family. (84 aa)
Q7A_932Hypothetical protein. (47 aa)
mtaDS-adenosylhomocysteine deaminase, Methylthioadenosine deaminase; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family. (439 aa)
Your Current Organism:
Methylophaga nitratireducenticrescens
NCBI taxonomy Id: 754476
Other names: ATCC BAA-2433, DSM 25689, M. nitratireducenticrescens, Methylophaga nitratireducenticrescens Villeneuve et al. 2013, Methylophaga sp. GP59, Methylophaga sp. JAM1, strain JAM1
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.