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Q7A_1971 Q7A_1971 Q7A_1681 Q7A_1681 MoaA MoaA Q7A_1970 Q7A_1970 cysI cysI AcnB AcnB ispH ispH thiC thiC edd edd Q7A_2255 Q7A_2255 Q7A_239 Q7A_239 queG queG leuC leuC Q7A_2558 Q7A_2558 Q7A_2559 Q7A_2559 rlmN rlmN Q7A_2619 Q7A_2619 Q7A_2621 Q7A_2621 Q7A_2649 Q7A_2649 rnfB rnfB rnfC rnfC nth nth EpmB EpmB lipA lipA nuoI nuoI Q7A_2876 Q7A_2876 Q7A_2877 Q7A_2877 nuoB nuoB queE queE bioB bioB Q7A_3060 Q7A_3060 moaA moaA Q7A_446 Q7A_446 pqqE pqqE Q7A_467 Q7A_467 Q7A_473 Q7A_473 Q7A_484 Q7A_484 HemN HemN nadA nadA miaB miaB Q7A_805 Q7A_805 Q7A_806 Q7A_806 Q7A_862 Q7A_862 pqqE-2 pqqE-2 Q7A_89 Q7A_89 Q7A_898 Q7A_898 Q7A_899 Q7A_899 Q7A_902 Q7A_902 Q7A_903 Q7A_903 Q7A_974 Q7A_974 MutY MutY Q7A_1264 Q7A_1264 rlmD rlmD Q7A_1534 Q7A_1534 Q7A_1561 Q7A_1561 rimO rimO
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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Q7A_1971Ferredoxin--NADP(+) reductase, actinobacterial (eukaryote-like) type. (458 aa)
Q7A_1681Fe-S oxidoreductase; PFAM: Domain of unknown function (DUF3362); Radical SAM superfamily; Radical SAM N-terminal; TIGRFAM: uncharacterized radical SAM protein YgiQ. (725 aa)
MoaAMolybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (301 aa)
Q7A_19704Fe-4S ferredoxin, iron-sulfur binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (101 aa)
cysISulfite reductase (NADPH) hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (566 aa)
AcnBAconitate hydratase 2; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (845 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (320 aa)
thiCThiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (603 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (607 aa)
Q7A_2255Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (509 aa)
Q7A_239Glutamate synthase (NADPH) small chain; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase small subunit family protein, proteobacterial. (482 aa)
queGEpoxyqueuosine (oQ) reductase QueG; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (357 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
Q7A_2558PFAM: GcpE protein; TIGRFAM: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase. (186 aa)
Q7A_2559PFAM: GcpE protein; TIGRFAM: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase. (156 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (368 aa)
Q7A_2619Assimilatory nitrate reductase large subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; BFD-like [2Fe-2S] binding domain; Molybdopterin oxidoreductase Fe4S4 domain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (883 aa)
Q7A_2621Nitrite reductase (NAD(P)H) large subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Nitrite and sulphite reductase 4Fe-4S domain; BFD-like [2Fe-2S] binding domain; Nitrite/Sulfite reductase ferredoxin-like half domain; TIGRFAM: nitrite reductase [NAD(P)H], large subunit. (809 aa)
Q7A_2649Hypothetical protein; PFAM: Radical SAM superfamily. (352 aa)
rnfBElectron transport complex protein RnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (186 aa)
rnfCElectron transport complex protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (508 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa)
EpmBLysyl-lysine 2,3-aminomutase; PFAM: Radical SAM superfamily; TIGRFAM: KamA family protein; lysine-2,3-aminomutase-related protein. (335 aa)
lipALipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (319 aa)
nuoINADH-ubiquinone oxidoreductase chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (163 aa)
Q7A_2876NADH-ubiquinone oxidoreductase chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (787 aa)
Q7A_2877NADH-ubiquinone oxidoreductase chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (432 aa)
nuoBNADH-ubiquinone oxidoreductase chain B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (162 aa)
queEQueuosine Biosynthesis QueE Radical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (213 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa)
Q7A_3060Coproporphyrinogen III oxidase-like protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (386 aa)
moaAMolybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (335 aa)
Q7A_446Respiratory nitrate reductase alpha chain; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; TIGRFAM: respiratory nitrate reductase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1251 aa)
pqqECoenzyme PQQ synthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (386 aa)
Q7A_467Ribonucleotide reductase of class III (anaerobic), activating protein; PFAM: Radical SAM superfamily; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein. (226 aa)
Q7A_473Putative protease; PFAM: Peptidase family U32. (301 aa)
Q7A_484Respiratory nitrate reductase alpha chain; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; TIGRFAM: respiratory nitrate reductase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1247 aa)
HemNCoproporphyrinogen III oxidase; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (370 aa)
miaBtRNA-i(6)A37 methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (455 aa)
Q7A_805NAD-dependent formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: formate dehydrogenase, alpha subunit, archaeal-type. (959 aa)
Q7A_806NAD-dependent formate dehydrogenase beta subunit; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Respiratory-chain NADH dehydrogenase 51 Kd subunit; SLBB domain. (515 aa)
Q7A_862ATP-binding region, ATPase-like:Histidine kinase, dimerization and phosphoacceptor region; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (396 aa)
pqqE-2Coenzyme PQQ synthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (397 aa)
Q7A_89PFAM: Uracil DNA glycosylase superfamily. (203 aa)
Q7A_898Formate dehydrogenase-O, major subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (957 aa)
Q7A_899Formate dehydrogenase iron-sulfur subunit. (194 aa)
Q7A_902Tungsten-containing formate dehydrogenase beta subunit; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Respiratory-chain NADH dehydrogenase 24 Kd subunit; Respiratory-chain NADH dehydrogenase 51 Kd subunit; SLBB domain. (565 aa)
Q7A_903Tungsten-containing formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: formate dehydrogenase, alpha subunit, archaeal-type; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (933 aa)
Q7A_974Sulfite reductase (NADPH) hemoprotein beta-component; PFAM: Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain. (552 aa)
MutYA/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (296 aa)
Q7A_12644Fe-4S ferredoxin, iron-sulfur binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa)
rlmDRNA methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (442 aa)
Q7A_1534PFAM: Uncharacterized protein family (UPF0051); TIGRFAM: FeS assembly protein SufB. (482 aa)
Q7A_1561TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (241 aa)
rimORibosomal protein S12p; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (436 aa)
Your Current Organism:
Methylophaga nitratireducenticrescens
NCBI taxonomy Id: 754476
Other names: ATCC BAA-2433, DSM 25689, M. nitratireducenticrescens, Methylophaga nitratireducenticrescens Villeneuve et al. 2013, Methylophaga sp. GP59, Methylophaga sp. JAM1, strain JAM1
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