(23 nodes) Mixed, incl. Protein transport across the cell outer membrane, and GspF/PilC family network (Methylophaga frappieri)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	yacG	Zinc-binding protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. (64 aa)
	zapD	Hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (258 aa)
	coaE	Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa)
	Q7C_2226	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (289 aa)
	Q7C_2227	Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain. (413 aa)
	Q7C_2228	Type IV fimbrial assembly, ATPase PilB; PFAM: Type II/IV secretion system protein; GSPII_E N-terminal domain; TIGRFAM: type IV-A pilus assembly ATPase PilB. (572 aa)
	Q7C_2229	Hypothetical protein. (42 aa)
	lysA	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (415 aa)
	dapF	Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (282 aa)
	Q7C_2232	PFAM: Protein of unknown function, DUF484. (234 aa)
	xerC	Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (306 aa)
	Q7C_259	General secretion pathway protein D; PFAM: Protein of unknown function (DUF3438); Bacterial type II and III secretion system protein; Belongs to the bacterial secretin family. (777 aa)
	Q7C_260	Hypothetical protein. (125 aa)
	Q7C_261	PFAM: Bacterial type II secretion system protein F domain. (407 aa)
	Q7C_262	Type IV fimbrial assembly, ATPase PilB; PFAM: GSPII_E N-terminal domain; Type II/IV secretion system protein. (549 aa)
	Q7C_263	Hypothetical protein. (220 aa)
	Q7C_264	Hypothetical protein. (557 aa)
	Q7C_265	Hypothetical protein. (51 aa)
	Q7C_266	Hypothetical protein; PFAM: Prokaryotic N-terminal methylation motif; TIGRFAM: prepilin-type N-terminal cleavage/methylation domain. (529 aa)
	Q7C_267	Hypothetical protein; PFAM: Prokaryotic N-terminal methylation motif; TIGRFAM: prepilin-type N-terminal cleavage/methylation domain. (276 aa)
	Q7C_268	Hypothetical protein; PFAM: Prokaryotic N-terminal methylation motif; TIGRFAM: prepilin-type N-terminal cleavage/methylation domain. (337 aa)
	Q7C_269	Hypothetical protein. (61 aa)
	Q7C_270	Hypothetical protein. (64 aa)

Your Current Organism:

Methylophaga frappieri

NCBI taxonomy Id: 754477
Other names: ATCC BAA-2434, DSM 25690, M. frappieri, Methylophaga frappieri Villeneuve et al. 2013, Methylophaga sp. JAM7, strain JAM7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Q7C_2226	Q7C_2227	Q7C_2226	Q7C_2227	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.	0.980
Q7C_2226	Q7C_2228	Q7C_2226	Q7C_2228	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	Type IV fimbrial assembly, ATPase PilB; PFAM: Type II/IV secretion system protein; GSPII_E N-terminal domain; TIGRFAM: type IV-A pilus assembly ATPase PilB.	0.970
Q7C_2226	Q7C_2229	Q7C_2226	Q7C_2229	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	Hypothetical protein.	0.527
Q7C_2226	Q7C_2232	Q7C_2226	Q7C_2232	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	PFAM: Protein of unknown function, DUF484.	0.527
Q7C_2226	Q7C_261	Q7C_2226	Q7C_261	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	PFAM: Bacterial type II secretion system protein F domain.	0.863
Q7C_2226	Q7C_262	Q7C_2226	Q7C_262	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	Type IV fimbrial assembly, ATPase PilB; PFAM: GSPII_E N-terminal domain; Type II/IV secretion system protein.	0.869
Q7C_2226	coaE	Q7C_2226	Q7C_2225	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	0.880
Q7C_2226	dapF	Q7C_2226	Q7C_2231	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.	0.541
Q7C_2226	lysA	Q7C_2226	Q7C_2230	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.	0.528
Q7C_2226	xerC	Q7C_2226	Q7C_2233	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.	0.529
Q7C_2226	yacG	Q7C_2226	Q7C_2223	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	Zinc-binding protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.	0.800
Q7C_2226	zapD	Q7C_2226	Q7C_2224	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	Hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.	0.832
Q7C_2227	Q7C_2226	Q7C_2227	Q7C_2226	Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.	Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	0.980
Q7C_2227	Q7C_2228	Q7C_2227	Q7C_2228	Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.	Type IV fimbrial assembly, ATPase PilB; PFAM: Type II/IV secretion system protein; GSPII_E N-terminal domain; TIGRFAM: type IV-A pilus assembly ATPase PilB.	0.987
Q7C_2227	Q7C_2229	Q7C_2227	Q7C_2229	Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.	Hypothetical protein.	0.527
Q7C_2227	Q7C_2232	Q7C_2227	Q7C_2232	Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.	PFAM: Protein of unknown function, DUF484.	0.527
Q7C_2227	Q7C_259	Q7C_2227	Q7C_259	Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.	General secretion pathway protein D; PFAM: Protein of unknown function (DUF3438); Bacterial type II and III secretion system protein; Belongs to the bacterial secretin family.	0.492
Q7C_2227	Q7C_262	Q7C_2227	Q7C_262	Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.	Type IV fimbrial assembly, ATPase PilB; PFAM: GSPII_E N-terminal domain; Type II/IV secretion system protein.	0.949
Q7C_2227	Q7C_266	Q7C_2227	Q7C_266	Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.	Hypothetical protein; PFAM: Prokaryotic N-terminal methylation motif; TIGRFAM: prepilin-type N-terminal cleavage/methylation domain.	0.531
Q7C_2227	Q7C_267	Q7C_2227	Q7C_267	Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.	Hypothetical protein; PFAM: Prokaryotic N-terminal methylation motif; TIGRFAM: prepilin-type N-terminal cleavage/methylation domain.	0.531