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Q7C_2354 Q7C_2354 anmK anmK pgi pgi ndk ndk nadK nadK Q7C_1050 Q7C_1050 Q7C_1061 Q7C_1061 Q7C_1073 Q7C_1073 Q7C_1098 Q7C_1098 Q7C_1154 Q7C_1154 Q7C_118 Q7C_118 Q7C_119 Q7C_119 tpiA tpiA Q7C_1228 Q7C_1228 Q7C_1267 Q7C_1267 Q7C_1274 Q7C_1274 glk glk lpxK lpxK Q7C_1292 Q7C_1292 Q7C_1297 Q7C_1297 adk adk Q7C_1302 Q7C_1302 Q7C_1325 Q7C_1325 gmk gmk Q7C_1356 Q7C_1356 Q7C_1392 Q7C_1392 Q7C_1408 Q7C_1408 Q7C_1410 Q7C_1410 Q7C_1446 Q7C_1446 Q7C_1449 Q7C_1449 Q7C_1508 Q7C_1508 Q7C_1561 Q7C_1561 Q7C_1622 Q7C_1622 Q7C_1623 Q7C_1623 Q7C_1676 Q7C_1676 Q7C_1698 Q7C_1698 Q7C_1699 Q7C_1699 Q7C_1701 Q7C_1701 Q7C_1762 Q7C_1762 Q7C_1768 Q7C_1768 Q7C_1774 Q7C_1774 Q7C_1778 Q7C_1778 Q7C_1780 Q7C_1780 aroK aroK Q7C_1816 Q7C_1816 Q7C_1873 Q7C_1873 Q7C_1924 Q7C_1924 Q7C_1943 Q7C_1943 gpmI gpmI Q7C_2064 Q7C_2064 Q7C_2069 Q7C_2069 Q7C_2091 Q7C_2091 ispE ispE prs prs Q7C_2127 Q7C_2127 pgk pgk Q7C_2154 Q7C_2154 Q7C_2155 Q7C_2155 proB proB Q7C_2201 Q7C_2201 coaE coaE Q7C_223 Q7C_223 thrB thrB hldE hldE Q7C_2250 Q7C_2250 Q7C_2261 Q7C_2261 Q7C_2276 Q7C_2276 argB argB Q7C_2344 Q7C_2344 Q7C_2448 Q7C_2448 Q7C_2449 Q7C_2449 Q7C_245 Q7C_245 Q7C_2557 Q7C_2557 Q7C_257 Q7C_257 Q7C_2575 Q7C_2575 ppk ppk Q7C_2646 Q7C_2646 Q7C_2663 Q7C_2663 tmk tmk eno eno Q7C_305 Q7C_305 Q7C_331 Q7C_331 Q7C_342 Q7C_342 Q7C_350 Q7C_350 Q7C_351 Q7C_351 Q7C_37 Q7C_37 Q7C_423 Q7C_423 Q7C_434 Q7C_434 Q7C_44 Q7C_44 cmk cmk Q7C_58 Q7C_58 Q7C_583 Q7C_583 coaX coaX Q7C_62 Q7C_62 Q7C_672 Q7C_672 Q7C_675 Q7C_675 pyrH pyrH Q7C_898 Q7C_898 thiL thiL Q7C_956 Q7C_956 Q7C_96 Q7C_96 Q7C_981 Q7C_981
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Q7C_2354Signal transduction histidine kinase CheA; PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Hpt domain. (589 aa)
anmKAnhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (375 aa)
pgiPFAM: Phosphoglucose isomerase; Belongs to the GPI family. (545 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
nadKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (287 aa)
Q7C_1050Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: EAL domain; HAMP domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (781 aa)
Q7C_1061PFAM: Protein kinase domain; Stage II sporulation protein E (SpoIIE). (642 aa)
Q7C_1073Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: GGDEF domain; CHASE domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain. (884 aa)
Q7C_1098Ribulosamine/erythrulosamine 3-kinase potentially involved in protein deglycation; PFAM: Fructosamine kinase. (295 aa)
Q7C_1154Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: GGDEF domain; Bacterial extracellular solute-binding proteins, family 3; TIGRFAM: diguanylate cyclase (GGDEF) domain. (449 aa)
Q7C_118Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (439 aa)
Q7C_119Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (259 aa)
Q7C_1228Hypothetical protein; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (455 aa)
Q7C_1267Signal transduction histidine kinase CheA; PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transducing histidine kinase, homodimeric domain; Hpt domain. (650 aa)
Q7C_1274Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (625 aa)
glkPFAM: Glucokinase; TIGRFAM: glucokinase, proteobacterial type; Belongs to the bacterial glucokinase family. (322 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (325 aa)
Q7C_1292PFAM: Trm112p-like protein; Belongs to the UPF0434 family. (58 aa)
Q7C_1297Phosphoglycolate phosphatase-like protein; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. (204 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
Q7C_1302Ketohexokinase(); PFAM: pfkB family carbohydrate kinase. (291 aa)
Q7C_1325GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (723 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (203 aa)
Q7C_1356PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (452 aa)
Q7C_1392Periplasmic Sensor signal transduction Histidine Kinase; PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (444 aa)
Q7C_1408Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (416 aa)
Q7C_1410Methanol utilization control sensor protein moxY, putative; PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS fold; TIGRFAM: PAS domain S-box. (573 aa)
Q7C_1446PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain. (854 aa)
Q7C_1449Diguanylate cyclase/phosphodiesterase; PFAM: EAL domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain. (841 aa)
Q7C_1508Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; NMT1/THI5 like; PAS fold; TIGRFAM: PAS domain S-box. (894 aa)
Q7C_1561PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (444 aa)
Q7C_1622Hypothetical protein; PFAM: Calcium/calmodulin dependent protein kinase II Association. (128 aa)
Q7C_1623Hypothetical protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; Bacterial signalling protein N terminal repeat; TIGRFAM: PAS domain S-box. (1118 aa)
Q7C_1676PFAM: Dak1 domain; TIGRFAM: dihydroxyacetone kinase, DhaK subunit. (329 aa)
Q7C_1698PFAM: HPr Serine kinase C-terminal domain. (160 aa)
Q7C_1699PFAM: PTS system fructose IIA component. (134 aa)
Q7C_1701Phosphoenolpyruvate-protein phosphotransferase of PTS system; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (584 aa)
Q7C_1762Hypothetical protein; PFAM: FIST C domain; FIST N domain. (380 aa)
Q7C_1768Signal transduction histidine kinase CheA; PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; Signal transducing histidine kinase, homodimeric domain; Hpt domain. (1899 aa)
Q7C_1774Triphosphoribosyl-dephospho-CoA synthetase; PFAM: ATP:dephospho-CoA triphosphoribosyl transferase. (292 aa)
Q7C_1778S-layer protein, putative; TIGRFAM: probable H4MPT-linked C1 transfer pathway protein. (340 aa)
Q7C_1780Delta 1-pyrroline-5-carboxylate synthetase; PFAM: Amino acid kinase family. (193 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (177 aa)
Q7C_1816Phosphate regulon sensor protein PhoR (SphS); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; Domain of unknown function (DUF3329); TIGRFAM: phosphate regulon sensor kinase PhoR. (429 aa)
Q7C_1873Two-component hybrid sensor and regulator; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain. (1135 aa)
Q7C_1924Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (118 aa)
Q7C_1943Nitrogen regulation protein ntrY; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (718 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
Q7C_2064Sensor protein PhoQ; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (445 aa)
Q7C_2069PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box. (985 aa)
Q7C_2091PFAM: Phosphoribulokinase / Uridine kinase family. (289 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (285 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (328 aa)
Q7C_2127Signal transduction histidine kinase, glucose-6-phosphate specific; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (305 aa)
pgkPFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (420 aa)
Q7C_2154PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (480 aa)
Q7C_2155Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (347 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (376 aa)
Q7C_2201Beta-ribofuranosylaminobenzene 5'-phosphate synthase; PFAM: GHMP kinases C terminal; GHMP kinases N terminal domain; TIGRFAM: beta-RFAP synthase. (336 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa)
Q7C_223Aspartokinase; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (406 aa)
thrBHomoserine kinase; PFAM: Phosphotransferase enzyme family; TIGRFAM: homoserine kinase, Neisseria type; Belongs to the pseudomonas-type ThrB family. (318 aa)
hldEADP-heptose synthase / D-glycero-beta-D-manno-heptose 7-phosphate kinase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (479 aa)
Q7C_2250Serine/threonine protein kinase; PFAM: Lipopolysaccharide kinase (Kdo/WaaP) family. (445 aa)
Q7C_2261PFAM: Protein of unknown function (DUF3301). (104 aa)
Q7C_2276Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain. (707 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (300 aa)
Q7C_2344Flagellar sensor histidine kinase FleS; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold. (369 aa)
Q7C_2448PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (162 aa)
Q7C_2449Deoxyadenosine kinase / Deoxyguanosine kinase; PFAM: Deoxynucleoside kinase. (219 aa)
Q7C_245Fructokinase; PFAM: pfkB family carbohydrate kinase. (277 aa)
Q7C_2557PFAM: GAF domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box. (1307 aa)
Q7C_257PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (447 aa)
Q7C_2575Hypothetical protein. (472 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (693 aa)
Q7C_2646PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (449 aa)
Q7C_2663PFAM: Phosphotransferase enzyme family. (324 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (208 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (425 aa)
Q7C_305Signal transduction histidine kinase, glucose-6-phosphate specific; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (450 aa)
Q7C_331Two-component system sensor protein; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (432 aa)
Q7C_342Aspartokinase associated with ectoine biosynthesis; PFAM: Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase. (480 aa)
Q7C_350Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (778 aa)
Q7C_351Hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (263 aa)
Q7C_37Sensor protein PhoQ; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (323 aa)
Q7C_423Integral membrane sensor signal transduction histidine kinase; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (453 aa)
Q7C_434Two-component sensor PilS; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (525 aa)
Q7C_44Carbohydrate kinase, FGGY(); PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain. (431 aa)
cmkPFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase. (221 aa)
Q7C_58Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain. (704 aa)
Q7C_583Nitrogen regulation protein NR(II); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold. (354 aa)
coaXPantothenate kinase type III, CoaX-like protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (257 aa)
Q7C_62PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (551 aa)
Q7C_672Hypothetical protein; PFAM: Lipopolysaccharide kinase (Kdo/WaaP) family. (737 aa)
Q7C_675PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (312 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
Q7C_898Sugar kinase; PFAM: pfkB family carbohydrate kinase. (294 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa)
Q7C_956Macrolide 2'-phosphotransferase I; PFAM: Phosphotransferase enzyme family. (297 aa)
Q7C_96PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (441 aa)
Q7C_981Hypothetical protein. (298 aa)
Your Current Organism:
Methylophaga frappieri
NCBI taxonomy Id: 754477
Other names: ATCC BAA-2434, DSM 25690, M. frappieri, Methylophaga frappieri Villeneuve et al. 2013, Methylophaga sp. JAM7, strain JAM7
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