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Q7C_1449 Q7C_1449 Q7C_1483 Q7C_1483 Q7C_150 Q7C_150 Q7C_1508 Q7C_1508 Q7C_1530 Q7C_1530 Q7C_1561 Q7C_1561 Q7C_1563 Q7C_1563 Q7C_1588 Q7C_1588 Q7C_1623 Q7C_1623 Q7C_1624 Q7C_1624 Q7C_1686 Q7C_1686 Q7C_1698 Q7C_1698 Q7C_1762 Q7C_1762 Q7C_1764 Q7C_1764 Q7C_1765 Q7C_1765 Q7C_1766 Q7C_1766 Q7C_1767 Q7C_1767 Q7C_1768 Q7C_1768 Q7C_1769 Q7C_1769 Q7C_1807 Q7C_1807 Q7C_1816 Q7C_1816 Q7C_1817 Q7C_1817 Q7C_1872 Q7C_1872 Q7C_1873 Q7C_1873 Q7C_1943 Q7C_1943 Q7C_1944 Q7C_1944 Q7C_2004 Q7C_2004 Q7C_2063 Q7C_2063 Q7C_2064 Q7C_2064 Q7C_2069 Q7C_2069 Q7C_2070 Q7C_2070 Q7C_2083 Q7C_2083 Q7C_2086 Q7C_2086 Q7C_2126 Q7C_2126 Q7C_2127 Q7C_2127 Q7C_2257 Q7C_2257 Q7C_2276 Q7C_2276 Q7C_2344 Q7C_2344 Q7C_2345 Q7C_2345 Q7C_2353 Q7C_2353 Q7C_2354 Q7C_2354 Q7C_2359 Q7C_2359 Q7C_2557 Q7C_2557 Q7C_256 Q7C_256 Q7C_257 Q7C_257 Q7C_2608 Q7C_2608 Q7C_2624 Q7C_2624 Q7C_2645 Q7C_2645 Q7C_2646 Q7C_2646 Q7C_305 Q7C_305 Q7C_306 Q7C_306 Q7C_324 Q7C_324 Q7C_330 Q7C_330 Q7C_331 Q7C_331 Q7C_36 Q7C_36 Q7C_37 Q7C_37 Q7C_373 Q7C_373 Q7C_423 Q7C_423 Q7C_424 Q7C_424 Q7C_433 Q7C_433 Q7C_434 Q7C_434 Q7C_562 Q7C_562 Q7C_58 Q7C_58 ntrC ntrC Q7C_583 Q7C_583 Q7C_62 Q7C_62 Q7C_66 Q7C_66 Q7C_68 Q7C_68 Q7C_884 Q7C_884 Q7C_96 Q7C_96 Q7C_97 Q7C_97 Q7C_1023 Q7C_1023 Q7C_1027 Q7C_1027 Q7C_1050 Q7C_1050 Q7C_1059 Q7C_1059 Q7C_1063 Q7C_1063 Q7C_1073 Q7C_1073 Q7C_114 Q7C_114 Q7C_1154 Q7C_1154 Q7C_1227 Q7C_1227 Q7C_1228 Q7C_1228 Q7C_1265 Q7C_1265 Q7C_1267 Q7C_1267 cheB cheB Q7C_1271 Q7C_1271 Q7C_1274 Q7C_1274 Q7C_13 Q7C_13 Q7C_1300 Q7C_1300 Q7C_1319 Q7C_1319 Q7C_1343 Q7C_1343 Q7C_1356 Q7C_1356 Q7C_1357 Q7C_1357 Q7C_1391 Q7C_1391 Q7C_1392 Q7C_1392 Q7C_1407 Q7C_1407 Q7C_1408 Q7C_1408 Q7C_1409 Q7C_1409 Q7C_1410 Q7C_1410 Q7C_1445 Q7C_1445 Q7C_1446 Q7C_1446
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Q7C_1449Diguanylate cyclase/phosphodiesterase; PFAM: EAL domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain. (841 aa)
Q7C_1483TIR domain-containing protein; PFAM: TIR domain. (266 aa)
Q7C_150WD-repeat protein; PFAM: WD domain, G-beta repeat. (346 aa)
Q7C_1508Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; NMT1/THI5 like; PAS fold; TIGRFAM: PAS domain S-box. (894 aa)
Q7C_1530PFAM: Protein of unknown function (DUF2859); TIGRFAM: integrating conjugative element protein, PFL_4695 family. (105 aa)
Q7C_1561PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (444 aa)
Q7C_1563PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (242 aa)
Q7C_1588Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: EAL domain; Cache domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (766 aa)
Q7C_1623Hypothetical protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; Bacterial signalling protein N terminal repeat; TIGRFAM: PAS domain S-box. (1118 aa)
Q7C_1624Response regulator receiver:Metal-dependent phosphohydrolase, HD subdomain protein; PFAM: HD domain; Response regulator receiver domain. (330 aa)
Q7C_1686Pas; PFAM: GGDEF domain; Response regulator receiver domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (434 aa)
Q7C_1698PFAM: HPr Serine kinase C-terminal domain. (160 aa)
Q7C_1762Hypothetical protein; PFAM: FIST C domain; FIST N domain. (380 aa)
Q7C_1764Twitching motility protein PilG; PFAM: Response regulator receiver domain. (136 aa)
Q7C_1765Twitching motility protein PilH; PFAM: Response regulator receiver domain. (121 aa)
Q7C_1766Type IV pili signal transduction protein PilI; PFAM: CheW-like domain. (183 aa)
Q7C_1767Type IV pilus biogenesis protein PilJ; PFAM: Methyl-accepting chemotaxis protein (MCP) signaling domain. (420 aa)
Q7C_1768Signal transduction histidine kinase CheA; PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; Signal transducing histidine kinase, homodimeric domain; Hpt domain. (1899 aa)
Q7C_1769PFAM: CheW-like domain. (155 aa)
Q7C_1807Response regulator of zinc sigma-54-dependent two-component system; PFAM: Bacterial regulatory protein, Fis family; Sigma-54 interaction domain. (310 aa)
Q7C_1816Phosphate regulon sensor protein PhoR (SphS); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; Domain of unknown function (DUF3329); TIGRFAM: phosphate regulon sensor kinase PhoR. (429 aa)
Q7C_1817PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; TIGRFAM: phosphate regulon transcriptional regulatory protein PhoB. (229 aa)
Q7C_1872PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (316 aa)
Q7C_1873Two-component hybrid sensor and regulator; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain. (1135 aa)
Q7C_1943Nitrogen regulation protein ntrY; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (718 aa)
Q7C_1944Nitrogen assimilation regulatory protein NtrX; PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain. (424 aa)
Q7C_2004Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY; PFAM: Response regulator receiver domain. (265 aa)
Q7C_2063PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (200 aa)
Q7C_2064Sensor protein PhoQ; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (445 aa)
Q7C_2069PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box. (985 aa)
Q7C_2070Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: EAL domain; GAF domain; GGDEF domain; Response regulator receiver domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (721 aa)
Q7C_2083Putative signal transduction protein; PFAM: HDOD domain. (287 aa)
Q7C_2086Two-component system response regulator-like protein; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (533 aa)
Q7C_2126PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (218 aa)
Q7C_2127Signal transduction histidine kinase, glucose-6-phosphate specific; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (305 aa)
Q7C_2257Hypothetical protein; PFAM: Multi-copper polyphenol oxidoreductase laccase; TIGRFAM: uncharacterized protein, YfiH family; Belongs to the multicopper oxidase YfiH/RL5 family. (181 aa)
Q7C_2276Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain. (707 aa)
Q7C_2344Flagellar sensor histidine kinase FleS; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold. (369 aa)
Q7C_2345Flagellar regulatory protein FleQ; PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain. (453 aa)
Q7C_2353Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY; PFAM: Response regulator receiver domain. (121 aa)
Q7C_2354Signal transduction histidine kinase CheA; PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Hpt domain. (589 aa)
Q7C_2359PFAM: Methyl-accepting chemotaxis protein (MCP) signaling domain. (385 aa)
Q7C_2557PFAM: GAF domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box. (1307 aa)
Q7C_256PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (218 aa)
Q7C_257PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (447 aa)
Q7C_2608Adenylate cyclase. (523 aa)
Q7C_2624PFAM: HAMP domain; Methyl-accepting chemotaxis protein (MCP) signaling domain. (716 aa)
Q7C_2645Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (211 aa)
Q7C_2646PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (449 aa)
Q7C_305Signal transduction histidine kinase, glucose-6-phosphate specific; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (450 aa)
Q7C_306PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (223 aa)
Q7C_324Serine phosphatase RsbU, regulator of sigma subunit; PFAM: HAMP domain; Stage II sporulation protein E (SpoIIE). (661 aa)
Q7C_330PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (232 aa)
Q7C_331Two-component system sensor protein; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (432 aa)
Q7C_36PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (225 aa)
Q7C_37Sensor protein PhoQ; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (323 aa)
Q7C_373PFAM: Methyl-accepting chemotaxis protein (MCP) signaling domain; PAS fold; TIGRFAM: PAS domain S-box. (434 aa)
Q7C_423Integral membrane sensor signal transduction histidine kinase; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (453 aa)
Q7C_424Copper-sensing two-component system response regulator CpxR; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (227 aa)
Q7C_433Type IV fimbriae expression regulatory protein PilR; PFAM: Response regulator receiver domain; Bacterial regulatory protein, Fis family; Sigma-54 interaction domain. (461 aa)
Q7C_434Two-component sensor PilS; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (525 aa)
Q7C_562Diguanylate cyclase; PFAM: GAF domain; GGDEF domain; Phytochrome region; PAS fold; TIGRFAM: diguanylate cyclase (GGDEF) domain. (684 aa)
Q7C_58Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain. (704 aa)
ntrCNitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (467 aa)
Q7C_583Nitrogen regulation protein NR(II); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold. (354 aa)
Q7C_62PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (551 aa)
Q7C_66PFAM: Response regulator receiver domain. (130 aa)
Q7C_68Two-component hybrid sensor and regulator; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (378 aa)
Q7C_884Carbamoylphosphate synthase large subunit; Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein. (131 aa)
Q7C_96PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (441 aa)
Q7C_97Two-component system response regulator QseB; PFAM: Transcriptional regulatory protein, C terminal. (58 aa)
Q7C_1023Chemotaxis protein CheV; PFAM: CheW-like domain; Response regulator receiver domain. (313 aa)
Q7C_1027Putative signal transduction protein; PFAM: HDOD domain. (293 aa)
Q7C_1050Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: EAL domain; HAMP domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (781 aa)
Q7C_1059Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: GGDEF domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain. (508 aa)
Q7C_1063PFAM: Response regulator receiver domain; ANTAR domain. (206 aa)
Q7C_1073Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: GGDEF domain; CHASE domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain. (884 aa)
Q7C_114PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (333 aa)
Q7C_1154Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: GGDEF domain; Bacterial extracellular solute-binding proteins, family 3; TIGRFAM: diguanylate cyclase (GGDEF) domain. (449 aa)
Q7C_1227Copper-sensing two-component system response regulator CpxR; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (225 aa)
Q7C_1228Hypothetical protein; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (455 aa)
Q7C_1265Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY; PFAM: Response regulator receiver domain. (125 aa)
Q7C_1267Signal transduction histidine kinase CheA; PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transducing histidine kinase, homodimeric domain; Hpt domain. (650 aa)
cheBChemotaxis response regulator protein-glutamate methylesterase CheB; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (341 aa)
Q7C_1271Positive regulator of CheA protein activity (CheW); PFAM: CheW-like domain. (159 aa)
Q7C_1274Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (625 aa)
Q7C_13Hypothetical protein; PFAM: EAL domain; HAMP domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (632 aa)
Q7C_1300PFAM: HDOD domain; TIGRFAM: uncharacterized domain HDIG. (283 aa)
Q7C_1319PFAM: Protein of unknown function, DUF484; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (355 aa)
Q7C_1343HD-GYP domain (HD superfamily hydrolase); PFAM: HDOD domain. (281 aa)
Q7C_1356PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (452 aa)
Q7C_1357Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (234 aa)
Q7C_1391PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (211 aa)
Q7C_1392Periplasmic Sensor signal transduction Histidine Kinase; PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (444 aa)
Q7C_1407Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (212 aa)
Q7C_1408Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (416 aa)
Q7C_1409Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (214 aa)
Q7C_1410Methanol utilization control sensor protein moxY, putative; PFAM: Histidine kinase; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS fold; TIGRFAM: PAS domain S-box. (573 aa)
Q7C_1445PFAM: HD domain; Response regulator receiver domain. (372 aa)
Q7C_1446PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain. (854 aa)
Your Current Organism:
Methylophaga frappieri
NCBI taxonomy Id: 754477
Other names: ATCC BAA-2434, DSM 25690, M. frappieri, Methylophaga frappieri Villeneuve et al. 2013, Methylophaga sp. JAM7, strain JAM7
Server load: low (14%) [HD]
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