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ppc ppc serC serC Q7C_1406 Q7C_1406 Q7C_1464 Q7C_1464 Q7C_1465 Q7C_1465 Q7C_1466 Q7C_1466 Q7C_1468 Q7C_1468 Q7C_1604 Q7C_1604 Q7C_1647 Q7C_1647 Q7C_1679 Q7C_1679 Q7C_1682 Q7C_1682 Q7C_1683 Q7C_1683 mch mch Q7C_1775 Q7C_1775 Q7C_1777 Q7C_1777 Q7C_1778 Q7C_1778 Q7C_1780 Q7C_1780 Q7C_1781 Q7C_1781 fbp fbp Q7C_1962 Q7C_1962 ffsA ffsA Q7C_1964 Q7C_1964 Q7C_1965 Q7C_1965 Q7C_2000 Q7C_2000 gpmI gpmI Q7C_2116 Q7C_2116 Q7C_2117 Q7C_2117 Q7C_2118 Q7C_2118 Q7C_2119 Q7C_2119 Q7C_2122 Q7C_2122 Q7C_2123 Q7C_2123 Q7C_2124 Q7C_2124 Q7C_2125 Q7C_2125 Q7C_2130 Q7C_2130 Q7C_2155 Q7C_2155 Q7C_2200 Q7C_2200 Q7C_2202 Q7C_2202 Q7C_2209 Q7C_2209 glyA glyA Q7C_2470 Q7C_2470 Q7C_2566 Q7C_2566 eno eno Q7C_298 Q7C_298 Q7C_299 Q7C_299 Q7C_300 Q7C_300 Q7C_301 Q7C_301 Q7C_350 Q7C_350 acsA acsA Q7C_759 Q7C_759 Q7C_8 Q7C_8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (944 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (348 aa)
Q7C_1406Methanol dehydrogenase large subunit protein; PFAM: Pyrrolo-quinoline quinone coenzyme N-terminus; Pyrrolo-quinoline quinone coenzyme C-terminus; PQQ enzyme repeat; TIGRFAM: PQQ-dependent dehydrogenase, methanol/ethanol family. (592 aa)
Q7C_1464NAD-dependent formate dehydrogenase gamma subunit; PFAM: Respiratory-chain NADH dehydrogenase 24 Kd subunit. (163 aa)
Q7C_1465NAD-dependent formate dehydrogenase beta subunit; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Respiratory-chain NADH dehydrogenase 51 Kd subunit; SLBB domain. (515 aa)
Q7C_1466NAD-dependent formate dehydrogenase alpha subunit; PFAM: Molybdopterin oxidoreductase; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: formate dehydrogenase, alpha subunit, archaeal-type. (956 aa)
Q7C_1468PFAM: NADH-dependant formate dehydrogenase delta subunit FdsD. (80 aa)
Q7C_1604PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (409 aa)
Q7C_1647MxaD gene product; PFAM: Polyketide cyclase / dehydrase and lipid transport. (187 aa)
Q7C_1679D-arabino-3-hexulose 6-phosphate formaldehyde lyase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: 3-hexulose-6-phosphate synthase. (213 aa)
Q7C_1682D-arabino-3-hexulose 6-phosphate formaldehyde lyase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: 3-hexulose-6-phosphate synthase. (211 aa)
Q7C_16836-phospho-3-hexuloisomerase; PFAM: SIS domain; TIGRFAM: 6-phospho 3-hexuloisomerase. (177 aa)
mchN(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (326 aa)
Q7C_1775PFAM: Formaldehyde-activating enzyme (Fae); TIGRFAM: formaldehyde-activating enzyme. (172 aa)
Q7C_1777Putative ATP-utilizing enzyme (ATP-grasp superfamily); PFAM: ATP-grasp domain. (313 aa)
Q7C_1778S-layer protein, putative; TIGRFAM: probable H4MPT-linked C1 transfer pathway protein. (340 aa)
Q7C_1780Delta 1-pyrroline-5-carboxylate synthetase; PFAM: Amino acid kinase family. (193 aa)
Q7C_1781PFAM: Pyridoxal-dependent decarboxylase conserved domain. (371 aa)
fbpFructose-1,6-bisphosphatase, type I; PFAM: Fructose-1-6-bisphosphatase. (337 aa)
Q7C_1962PFAM: GXGXG motif; TIGRFAM: formylmethanofuran dehydrogenase subunit C. (272 aa)
ffsAFormylmethanofuran--tetrahydromethanopterin N-formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family. (300 aa)
Q7C_1964PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A. (555 aa)
Q7C_1965TIGRFAM: formylmethanofuran dehydrogenase subunit B. (426 aa)
Q7C_2000PFAM: Protein of unknown function (DUF556). (228 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
Q7C_2116MxaL protein, putative. (324 aa)
Q7C_2117MxaK protein, putative. (189 aa)
Q7C_2118MxaC, protein involved in Ca2+ insertion into methanol dehydrogenase; PFAM: von Willebrand factor type A domain. (326 aa)
Q7C_2119MxaA protein. (311 aa)
Q7C_2122Methanol dehydrogenase, small subunit; Catalyzes the oxidation of primary alcohols including methanol. (91 aa)
Q7C_2123PFAM: Cytochrome c; TIGRFAM: cytochrome c(L), periplasmic. (195 aa)
Q7C_2124PFAM: Bacterial extracellular solute-binding proteins, family 3; TIGRFAM: methanol oxidation system protein MoxJ. (287 aa)
Q7C_2125Methanol dehydrogenase large subunit protein; PFAM: Pyrrolo-quinoline quinone coenzyme N-terminus; Pyrrolo-quinoline quinone coenzyme C-terminus; PQQ enzyme repeat; TIGRFAM: PQQ-dependent dehydrogenase, methanol/ethanol family. (629 aa)
Q7C_2130MxaD protein; PFAM: Polyketide cyclase / dehydrase and lipid transport. (172 aa)
Q7C_2155Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (347 aa)
Q7C_2200PFAM: Methylene-tetrahydromethanopterin dehydrogenase, N-terminal. (253 aa)
Q7C_2202PFAM: Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Shikimate / quinate 5-dehydrogenase. (288 aa)
Q7C_2209Methanol dehydrogenase large subunit protein; PFAM: Pyrrolo-quinoline quinone coenzyme N-terminus; Pyrrolo-quinoline quinone coenzyme C-terminus; PQQ enzyme repeat; TIGRFAM: PQQ-dependent dehydrogenase, methanol/ethanol family. (592 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
Q7C_2470Phosphoserine phosphatase; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (281 aa)
Q7C_2566PFAM: Formaldehyde-activating enzyme (Fae); TIGRFAM: formaldehyde-activating enzyme. (183 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (425 aa)
Q7C_298MxaL protein, putative. (297 aa)
Q7C_299Hypothetical protein. (169 aa)
Q7C_300MxaC, protein involved in Ca2+ insertion into methanol dehydrogenase; PFAM: von Willebrand factor type A domain. (338 aa)
Q7C_301Hypothetical protein. (288 aa)
Q7C_350Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (778 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
Q7C_759PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A. (552 aa)
Q7C_8PFAM: Formaldehyde-activating enzyme (Fae); TIGRFAM: formaldehyde-activating enzyme. (201 aa)
Your Current Organism:
Methylophaga frappieri
NCBI taxonomy Id: 754477
Other names: ATCC BAA-2434, DSM 25690, M. frappieri, Methylophaga frappieri Villeneuve et al. 2013, Methylophaga sp. JAM7, strain JAM7
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