STRINGSTRING
Q7C_1214 Q7C_1214 Q7C_1397 Q7C_1397 Q7C_1427 Q7C_1427 Q7C_1429 Q7C_1429 yidC yidC tatC tatC Q7C_1977 Q7C_1977 tatA tatA secB secB Q7C_2291 Q7C_2291 yajC yajC secD secD secF secF secE secE secY secY Q7C_2582 Q7C_2582 Q7C_2583 Q7C_2583 Q7C_259 Q7C_259 Q7C_262 Q7C_262 ftsY ftsY ffh ffh secA secA Q7C_960 Q7C_960
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Q7C_1214Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (110 aa)
Q7C_1397PFAM: Outer membrane efflux protein; TIGRFAM: type I secretion outer membrane protein, TolC family. (438 aa)
Q7C_1427Inner membrane protein of type IV secretion of T-DNA complex, VirB6; PFAM: TrbL/VirB6 plasmid conjugal transfer protein. (335 aa)
Q7C_1429PFAM: Type IV secretion system proteins; TIGRFAM: P-type DNA transfer protein VirB5. (239 aa)
yidCInner membrane protein translocase component YidC, long form; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (548 aa)
tatCTwin-arginine translocation protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (247 aa)
Q7C_1977Twin-arginine translocation protein TatB; PFAM: mttA/Hcf106 family; TIGRFAM: twin arginine-targeting protein translocase TatB. (95 aa)
tatATwin-arginine translocation protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (81 aa)
secBProtein export cytoplasm chaperone protein; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (163 aa)
Q7C_2291PFAM: Outer membrane efflux protein; TIGRFAM: type I secretion outer membrane protein, TolC family. (414 aa)
yajCPreprotein translocase subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (108 aa)
secDProtein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (618 aa)
secFProtein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (316 aa)
secEPreprotein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (98 aa)
secYPreprotein translocase secY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (450 aa)
Q7C_2582ABC-type bacteriocin/lantibiotic exporters peptidase domain protein; PFAM: ABC transporter transmembrane region; ABC transporter; Peptidase C39 family; TIGRFAM: type I secretion system ABC transporter, HlyB family. (735 aa)
Q7C_2583PFAM: HlyD family secretion protein; TIGRFAM: type I secretion membrane fusion protein, HlyD family. (466 aa)
Q7C_259General secretion pathway protein D; PFAM: Protein of unknown function (DUF3438); Bacterial type II and III secretion system protein; Belongs to the bacterial secretin family. (777 aa)
Q7C_262Type IV fimbrial assembly, ATPase PilB; PFAM: GSPII_E N-terminal domain; Type II/IV secretion system protein. (549 aa)
ftsYSignal recognition particle receptor protein FtsY (alpha subunit); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (373 aa)
ffhSignal recognition particle, subunit Ffh SRP54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individu [...] (456 aa)
secAProtein export cytoplasm protein SecA ATPase RNA helicase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (908 aa)
Q7C_960Type IV secretion system protein VirD4; PFAM: TraG/TraD family. (671 aa)
Your Current Organism:
Methylophaga frappieri
NCBI taxonomy Id: 754477
Other names: ATCC BAA-2434, DSM 25690, M. frappieri, Methylophaga frappieri Villeneuve et al. 2013, Methylophaga sp. JAM7, strain JAM7
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