STRINGSTRING
AFZ52260.1 AFZ52260.1 AFZ52490.1 AFZ52490.1 AFZ52582.1 AFZ52582.1 AFZ52613.1 AFZ52613.1 AFZ52836.1 AFZ52836.1 AFZ52989.1 AFZ52989.1 AFZ53238.1 AFZ53238.1 AFZ53241.1 AFZ53241.1 AFZ54551.1 AFZ54551.1 AFZ54758.1 AFZ54758.1 AFZ54904.1 AFZ54904.1 AFZ55040.1 AFZ55040.1 AFZ55513.1 AFZ55513.1 AFZ53949.1 AFZ53949.1 AFZ53969.1 AFZ53969.1 AFZ54301.1 AFZ54301.1 AFZ54406.1 AFZ54406.1 AFZ52318.1 AFZ52318.1 AFZ53252.1 AFZ53252.1 AFZ53481.1 AFZ53481.1 AFZ53625.1 AFZ53625.1 AFZ53626.1 AFZ53626.1 AFZ53704.1 AFZ53704.1 AFZ53840.1 AFZ53840.1 AFZ53841.1 AFZ53841.1 AFZ53849.1 AFZ53849.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFZ52260.1PAS/PAC sensor hybrid histidine kinase; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 001789:IPR013767:IPR013655:IPR013656; KEGG: amr:AM1_5107 serine/threonine protein kinase and signal transduction histidine kinase (STHK) with GAF and PAS/PAC sensor; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosp [...] (1150 aa)
AFZ52490.1Putative PAS/PAC sensor protein; PFAM: HAMP domain; Cache domain; Stage II sporulation protein E (SpoIIE); PAS fold; TIGRFAM: PAS domain S-box; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterProIPR004010:IPR003660:IPR013767:IPR010822:IPR 001610:IPR001932:IPR000014; KEGG: cyh:Cyan8802_0823 putative PAS/PAC sensor protein; PFAM: Sporulation stage II, protein E C-terminal; HAMP linker domain; Cache; PAS fold; SMART: Protein phosphatase 2C-related; HAMP linker domain; PAC motif; SPTR: Putative PAS/PAC sensor protein; TIGRFAM: PAS. (832 aa)
AFZ52582.1PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000644:IPR003018:IPR013767:IPR013655:IPR 003661:IPR003594:IPR001789:IPR000014:IPR001610; KEGG: syn:slr1759 hybrid sensory kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; GAF; Cystathionine beta-synthase, core; PAS fold; PAS fold-3; Signal trans [...] (1474 aa)
AFZ52613.1Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; FHA domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2200 FOG: EAL domain; InterProIPR000253:IPR013767:IPR000160:IPR001633:IPR 000014; KEGG: cyp:PCC8801_1348 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; Forkhead-associated; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Forkhead-associated; PAS; Diguanylate cyclase, predicted; SPTR: Diguanylate c [...] (826 aa)
AFZ52836.1PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR003018:IPR001610:IPR003661:IPR 003594:IPR001789:IPR013655; KEGG: ava:Ava_4701 multi-sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; GAF; PAS fold-3; Signal transduction response regulator, receiver domain; SMART: ATPase-like, ATP-bind [...] (852 aa)
AFZ52989.1Multi-sensor signal transduction histidine kinase; PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterProIPR000014:IPR000644:IPR001789:IPR001610:IPR 003661:IPR003594:IPR013767:IPR013655; KEGG: ava:Ava_0647 multi-sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; Cystathionine beta-synthase, core; Signal transduction response regulator, receiver domain; PAS fo [...] (1115 aa)
AFZ53238.1PAS/PAC sensor hybrid histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001610:IPR000014:IPR003661:IPR003594:IPR 001789:IPR013655:IPR013656; KEGG: ava:Ava_4701 multi-sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; PAS fold-4; Signal transduction response regulator [...] (972 aa)
AFZ53241.1Putative PAS/PAC sensor protein; PFAM: CheB methylesterase; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG2202 FOG: PAS/PAC domain; InterProIPR000014:IPR001610:IPR013767:IPR013655:IPR 013656; KEGG: cyn:Cyan7425_1390 multi-sensor hybrid histidine kinase; PFAM: PAS fold-3; PAS fold; PAS fold-4; SMART: PAC motif; PAS; SPTR: PAS fold family; TIGRFAM: PAS. (530 aa)
AFZ54551.1Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR013767:IPR013655:IPR000160:IPR001633:IPR 000014:IPR001610; KEGG: cyc:PCC7424_1286 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS fold; PAS fold-3; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, [...] (1220 aa)
AFZ54758.1Putative PAS/PAC sensor protein; PFAM: Response regulator receiver domain; Stage II sporulation protein E (SpoIIE); PAS fold; TIGRFAM: PAS domain S-box; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterProIPR000014:IPR001789:IPR013767:IPR010822:IPR 001610:IPR001932; KEGG: amr:AM1_5976 two-component response regulator, putative; PFAM: Sporulation stage II, protein E C-terminal; Signal transduction response regulator, receiver domain; PAS fold; SMART: Signal transduction response regulator, receiver domain; PAS; PAC motif; Protein phosphatase 2C-related; SPTR: Two-c [...] (671 aa)
AFZ54904.1Diguanylate cyclase with PAS/PAC sensor; PFAM: GGDEF domain; FHA domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000253:IPR000014:IPR000160:IPR013767; KEGG: cyt:cce_4177 hypothetical protein; PFAM: Diguanylate cyclase, predicted; Forkhead-associated; PAS fold; SMART: Diguanylate cyclase, predicted; Forkhead-associated; PAS; SPTR: Putative uncharacterized protein; TIGRFAM: Diguanylate cyclase, predicted; PAS. (599 aa)
AFZ55040.1PFAM: GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003018:IPR003661:IPR 003594:IPR001789:IPR013767:IPR008207; KEGG: sse:Ssed_2865 signal transduction histidine kinase-like protein; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold; GAF; Signal transduction response regulator, [...] (1594 aa)
AFZ55513.1PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 001789:IPR013655:IPR013656:IPR013767; KEGG: ana:all4097 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; PAS fold-4; PAS fold; Signal transduction response regulator, receiver domai [...] (1472 aa)
AFZ53949.1Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR000014:IPR000160:IPR001633:IPR013767; KEGG: npu:Npun_AR143 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS; SPTR: Digu [...] (847 aa)
AFZ53969.1PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 001789:IPR013655:IPR003018; KEGG: gfo:GFO_0848 two-component system sensor histidine kinase/response regulator hybrid; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; GAF; Signal transduction response regulator, receiver do [...] (1223 aa)
AFZ54301.1Multi-sensor signal transduction histidine kinase; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG5002 Signal transduction histidine kinase; InterProIPR003660:IPR013767:IPR003661:IPR003594:IPR 000014; KEGG: cyc:PCC7424_1982 multi-sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; HAMP linker domain; PAS fold; SMART: ATPase-like, ATP-binding domain; Signal [...] (654 aa)
AFZ54406.1PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; GAF domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR013656:IPR003018:IPR003661:IPR003594:IPR 001789:IPR000014; KEGG: tel:tll1282 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-4; GAF; Signal transduction response regulator, receiver domain; SMART: ATPase-like, AT [...] (1244 aa)
AFZ52318.1Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; Response regulator receiver domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014:IPR000160:IPR001789:IPR001610:IPR 001633:IPR013767; KEGG: syn:slr1305 regulatory components of sensory transduction system; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; Signal transduction response re [...] (829 aa)
AFZ53252.1PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 001789:IPR008207:IPR013655; KEGG: syp:SYNPCC7002_A0996 two-component hybrid sensor kinase/response regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; Signal transduction response regulator, receiver doma [...] (1390 aa)
AFZ53481.1PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterProIPR013655:IPR003018:IPR003661:IPR003594:IPR 001789:IPR000014:IPR001610; KEGG: ana:alr3120 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; GAF; Signal transduction response regulator, receiver domain; SMART: ATPase-like, [...] (879 aa)
AFZ53625.1PAS sensor protein; PFAM: PAS fold; TIGRFAM: PAS domain S-box; InterPro IPR013655:IPR003018:IPR000014:IPR001610; KEGG: ava:Ava_4631 multi-sensor hybrid histidine kinase; PFAM: PAS fold-3; GAF; SMART: PAC motif; GAF; SPTR: Putative Histidine kinase; TIGRFAM: PAS. (526 aa)
AFZ53626.1Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR013655:IPR013767:IPR000160:IPR001633:IPR 000014:IPR001610; KEGG: mei:Msip34_1699 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS fold-3; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, p [...] (642 aa)
AFZ53704.1PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG3920 Signal transduction histidine kinase; InterProIPR000014:IPR003018:IPR001610:IPR003594:IPR 013655:IPR013767:IPR011495; KEGG: cyb:CYB_1653 sensory box histidine kinase; PFAM: Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain; GAF; PAS fold-3; PAS fold; ATPase-like, ATP-binding domain; SMART: GAF; PAS; PAC motif; ATPase-like, ATP-binding domain; SPTR: Sensory box histidine kinase; TIGRFAM: PAS. (1383 aa)
AFZ53840.1Diguanylate cyclase/phosphodiesterase with PAS/PAC and periplasmic sensors; PFAM: EAL domain; GGDEF domain; Bacterial extracellular solute-binding proteins, family 3; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014:IPR000160:IPR001638:IPR001610:IPR 001633:IPR013655; KEGG: cyn:Cyan7425_3561 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; Extracellu [...] (1118 aa)
AFZ53841.1Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014:IPR000160:IPR001610:IPR001633:IPR 013767; KEGG: cyh:Cyan8802_4489 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAC motif; [...] (596 aa)
AFZ53849.1Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; GGDEF domain; PAS fold; FHA domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014:IPR000160:IPR000253:IPR001633:IPR 013767; KEGG: cyp:PCC8801_1348 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; Forkhead-associated; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylat [...] (833 aa)
Your Current Organism:
Cyanobacterium aponinum
NCBI taxonomy Id: 755178
Other names: C. aponinum PCC 10605, Cyanobacterium aponinum PCC 10605, Cyanobacterium sp. PCC 10605
Server load: low (38%) [HD]