STRINGSTRING
ntpA ntpA phoA phoA ADJ62129.1 ADJ62129.1 folK folK ADJ62854.1 ADJ62854.1 folP folP ribF ribF ADJ62995.1 ADJ62995.1 ribH ribH folE2 folE2 nfnB nfnB folC folC thyA thyA folA folA ribH-2 ribH-2 ribAB ribAB ribD ribD ribE ribE folB folB folE folE ribA ribA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ntpAdATP pyrophosphohydrolase protein. (167 aa)
phoAAlkaline phosphatase D protein. (542 aa)
ADJ62129.1Phosphatase (HAD superfamily). (244 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase protein. (161 aa)
ADJ62854.14-hydroxyphenylacetate 3-monooxygenase, small chain, protein. (190 aa)
folP7,8-dihydropteroate synthase protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa)
ribFRiboflavin biosynthesis protein; Belongs to the ribF family. (325 aa)
ADJ62995.14-hydroxyphenylacetate 3-monooxygenase small chain protein. (166 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase (riboflavin synthase beta chain) protein; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (169 aa)
folE2Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (303 aa)
nfnBOxygen-insensitive nitroreductase protein. (220 aa)
folCBifunctional folylpolyglutamate synthase/dihydrofolate synthase protein; Belongs to the folylpolyglutamate synthase family. (437 aa)
thyAThymidylate synthetase protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (323 aa)
folADihydrofolate reductase oxidoreductase protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (164 aa)
ribH-26,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (161 aa)
ribAB3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (373 aa)
ribDDiaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (354 aa)
ribERiboflavin synthase (alpha chain) protein. (206 aa)
folBDihydroneopterin aldolase protein. (131 aa)
folEGTP cyclohydrolase I protein. (254 aa)
ribAGTP cyclohydrolase II protein; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (228 aa)
Your Current Organism:
Herbaspirillum seropedicae
NCBI taxonomy Id: 757424
Other names: H. seropedicae SmR1, Herbaspirillum seropedicae SmR1, Herbaspirillum seropedicae str. SmR1, Herbaspirillum seropedicae strain SmR1
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.