STRINGSTRING
hrpX hrpX hrcU hrcU hrcJ hrcJ hrcC hrcC pilN pilN bfpE bfpE pilS pilS pilV pilV ADJ62458.1 ADJ62458.1 fhaC fhaC exbB2 exbB2 exbD2 exbD2 tolB tolB tolA tolA exbD-4 exbD-4 tolQ tolQ yajC yajC secD secD secF secF hlyB hlyB ADJ62951.1 ADJ62951.1 ADJ63050.1 ADJ63050.1 ADJ63051.1 ADJ63051.1 ADJ63314.1 ADJ63314.1 ADJ63315.1 ADJ63315.1 lolA lolA flhB flhB flhA flhA flhF flhF fliR fliR fliQ fliQ fliP fliP fliJ fliJ fliI fliI flhB-2 flhB-2 ADJ63732.1 ADJ63732.1 ADJ63736.1 ADJ63736.1 ADJ63885.1 ADJ63885.1 ADJ63894.1 ADJ63894.1 tig tig ADJ64101.1 ADJ64101.1 tonB-3 tonB-3 exbD-5 exbD-5 ADJ64106.1 ADJ64106.1 lolD lolD lolE lolE exbD-6 exbD-6 exbB-3 exbB-3 ADJ64312.1 ADJ64312.1 hlyD hlyD cyaB cyaB ADJ64532.1 ADJ64532.1 ADJ64533.1 ADJ64533.1 sunT sunT ADJ64650.1 ADJ64650.1 fhaC-2 fhaC-2 ADJ64886.1 ADJ64886.1 ADJ65005.1 ADJ65005.1 ADJ65131.1 ADJ65131.1 comEA comEA ADJ65189.1 ADJ65189.1 ADJ65375.1 ADJ65375.1 lolB lolB ADJ65412.1 ADJ65412.1 ADJ65498.1 ADJ65498.1 ADJ65501.1 ADJ65501.1 ADJ65503.1 ADJ65503.1 ADJ65504.1 ADJ65504.1 ADJ65507.1 ADJ65507.1 ADJ65508.1 ADJ65508.1 ADJ65510.1 ADJ65510.1 ADJ65511.1 ADJ65511.1 ADJ65512.1 ADJ65512.1 tatC tatC tatB tatB tatA tatA ftsY ftsY pilQ pilQ vgr-2 vgr-2 yidC yidC ADJ65812.1 ADJ65812.1 ADJ66155.1 ADJ66155.1 hrcS hrcS hrcR hrcR hrcN hrcN hrcV hrcV ADJ62282.1 ADJ62282.1 ADJ62277.1 ADJ62277.1 ADJ62274.1 ADJ62274.1 vgr vgr ADJ62265.1 ADJ62265.1 ADJ62264.1 ADJ62264.1 ADJ62261.1 ADJ62261.1 ADJ62260.1 ADJ62260.1 ADJ62258.1 ADJ62258.1 ADJ62257.1 ADJ62257.1 ADJ62256.1 ADJ62256.1 ADJ62255.1 ADJ62255.1 tonB-2 tonB-2 exbB-2 exbB-2 exbD-3 exbD-3 ADJ62167.1 ADJ62167.1 exbB exbB exbD-2 exbD-2 ffh ffh pilC pilC secA secA ADJ61832.1 ADJ61832.1 exbD exbD ADJ61818.1 ADJ61818.1 ADJ61816.1 ADJ61816.1 ADJ61805.1 ADJ61805.1 ADJ61776.1 ADJ61776.1 gspG gspG secB secB secY secY secE secE gshA gshA ADJ61550.1 ADJ61550.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hrpXType III secretion HprX protein. (262 aa)
hrcUType III secretion HrcU transmembrane protein. (371 aa)
hrcJType III secretion HrcJ lipoprotein. (292 aa)
hrcCType II/III HrcC transmembrane protein. (693 aa)
pilNType IVB pilus formation outer membrane protein. (602 aa)
bfpEGeneral protein secretion (BfpE) protein. (357 aa)
pilSType IV pilus assemby PilS protein. (183 aa)
pilVType IV prepilin PilV protein. (467 aa)
ADJ62458.1VGR-related protein. (928 aa)
fhaCHemolysin activation/secretion protein. (565 aa)
exbB2Biopolymer transport ExbB-like transmembrane protein. (201 aa)
exbD2Biopolymer transport ExbD-related transmembrane protein. (142 aa)
tolBPeriplasmic component of the Tol biopolymer transport system protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (428 aa)
tolATolA-related transport transmembrane protein. (318 aa)
exbD-4Biopolymer transport ExbD/TolR protein. (144 aa)
tolQMotA/TolQ/ExbB proton channel family protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (234 aa)
yajCPreprotein translocase transmembrane protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (110 aa)
secDExport membrane protein SecD transmembrane; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (634 aa)
secFPreprotein translocase subunit SecF protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (314 aa)
hlyBHemolysin activation translocator protein. (581 aa)
ADJ62951.1YecA family protein. (233 aa)
ADJ63050.1Signal peptide protein. (1300 aa)
ADJ63051.1Outer membrane lipoprotein. (588 aa)
ADJ63314.1Type I antifreeze protein:HlyD family secretion protein. (457 aa)
ADJ63315.1Conserved hypothetical protein; S - Function unknown. (553 aa)
lolAOuter-membrane lipoprotein-sorting protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (237 aa)
flhBFlagellar biosynthesis FlhB transmembrane protein; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (391 aa)
flhAFlagellar biosynthesis FlhA transmembrane protein; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (705 aa)
flhFFlagellar biosynthesis GTP-binding protein. (494 aa)
fliRFliR component of the flagellar biosynthesis pathway; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (267 aa)
fliQFlagellar biosynthetic FliQ protein; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliPFlagellar biosynthetic protein FliP precursor protein; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (244 aa)
fliJFlagellar protein. (146 aa)
fliIFlagellum-specific ATP synthase protein. (468 aa)
flhB-2Flagellar biosynthetic protein. (114 aa)
ADJ63732.1Conserved hypothetical protein; S - Function unknown. (175 aa)
ADJ63736.1ABC-type transporter ATPase component protein. (234 aa)
ADJ63885.1ABC-type export system, ATP-binding subunit protein. (240 aa)
ADJ63894.1Conserved hypothetical protein; S - Function unknown. (192 aa)
tigPeptidyl-prolyl cis/trans isomerase (trigger factor) protein; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (449 aa)
ADJ64101.1Signal peptide protein. (276 aa)
tonB-3Periplasmic protein TonB, links inner and outer membranes, protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (238 aa)
exbD-5Biopolymer transport ExbD/TolR protein. (132 aa)
ADJ64106.1Biopolymer transport protein. (241 aa)
lolDABC-type lipoprotein release transport system, ATPase component protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (236 aa)
lolEABC-type lipoprotein release transport system, permease component protein. (421 aa)
exbD-6Biopolymer transport ExbD/TolR protein. (139 aa)
exbB-3Biopolymer transport transmembrane protein. (243 aa)
ADJ64312.1Hypothetical protein; S - Function unknown. (265 aa)
hlyDHemolysin secretion-related transmembrane protein. (447 aa)
cyaBABC-type bacteriocin/lantibiotic (cyclolysin-type) secretion transporter protein. (726 aa)
ADJ64532.1Centriolin protein. (517 aa)
ADJ64533.1Hemolysin-type secretion transmembrane protein. (386 aa)
sunTATP-binding cassette, subfamily C, bacterial LapB; ABC-type bacteriocin/lantibiotic exporter, containing an N-terminal double-glycine peptidase domain protein. (730 aa)
ADJ64650.1ABC-type antimicrobial peptide transport system, ATPase component protein. (245 aa)
fhaC-2Hemolysin activation/secretion protein. (584 aa)
ADJ64886.1VGR-related protein. (824 aa)
ADJ65005.1Conserved hypothetical protein; S - Function unknown. (453 aa)
ADJ65131.1Type 4 fimbrial pilin related transmembrane protein. (157 aa)
comEADNA uptake protein. (123 aa)
ADJ65189.1Conserved hypothetical signal peptide protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (203 aa)
ADJ65375.1Transmembrane protein. (317 aa)
lolBOuter-membrane lipoprotein lolB precursor lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (210 aa)
ADJ65412.1Conserved hypothetical protein; S - Function unknown. (454 aa)
ADJ65498.1Transmembrane protein. (1266 aa)
ADJ65501.1Conserved hypothetical protein; S - Function unknown. (375 aa)
ADJ65503.1Conserved hypothetical protein; S - Function unknown. (362 aa)
ADJ65504.1Conserved hypothetical protein; S - Function unknown. (614 aa)
ADJ65507.1Conserved hypothetical protein; S - Function unknown. (497 aa)
ADJ65508.1Conserved hypothetical protein; S - Function unknown. (166 aa)
ADJ65510.1Transmembrane protein. (209 aa)
ADJ65511.1Conserved hypothetical protein; S - Function unknown. (448 aa)
ADJ65512.1Type IV / VI secretion system transmembrane protein. (257 aa)
tatCSec-independent protein translocase protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (256 aa)
tatBSec-independent protein translocase protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (173 aa)
tatASec-independent protein translocase protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (67 aa)
ftsYSignal recognition particle GTPase involved in cell division protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (321 aa)
pilQFimbrial type-4 assembly signal peptide protein. (674 aa)
vgr-2VGR-related type VI secretion system protein. (886 aa)
yidCInner-membrane transmembrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (542 aa)
ADJ65812.1Multiple antibiotic resistance protein. (229 aa)
ADJ66155.1Conserved hypothetical protein; S - Function unknown. (136 aa)
hrcSType III secretion HrcS protein. (87 aa)
hrcRType III secretion HrcR transmembrane protein. (220 aa)
hrcNType III secretion ATP synthase protein. (460 aa)
hrcVType III secretion HrcV transmembrane protein. (695 aa)
ADJ62282.1VGR-related protein. (982 aa)
ADJ62277.1Transmembrane protein. (1291 aa)
ADJ62274.1Conserved hypothetical protein; S - Function unknown. (375 aa)
vgrVGR-related type VI secretion system protein. (944 aa)
ADJ62265.1Conserved hypothetical protein; S - Function unknown. (360 aa)
ADJ62264.1Conserved hypothetical protein; S - Function unknown. (614 aa)
ADJ62261.1Conserved hypothetical protein; S - Function unknown. (495 aa)
ADJ62260.1Conserved hypothetical protein; S - Function unknown. (166 aa)
ADJ62258.1Transmembrane protein. (174 aa)
ADJ62257.1Conserved hypothetical protein; S - Function unknown. (448 aa)
ADJ62256.1Transmembrane protein. (263 aa)
ADJ62255.1VGR-related protein. (954 aa)
tonB-2TonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (232 aa)
exbB-2Biopolymer transport transmembrane protein. (243 aa)
exbD-3Biopolymer transport ExbD/TolR protein. (138 aa)
ADJ62167.1Transmembrane protein. (242 aa)
exbBBiopolymer transport transmembrane protein; MotA/TolQ/ExbB proton channel family. (231 aa)
exbD-2Biopolymer transport ExbD/TolR protein. (148 aa)
ffhSignal recognition particle subunit SRP54 protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the indiv [...] (456 aa)
pilCBacterial type II secretion system protein. (415 aa)
secAPreprotein translocase SecA subunit protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (918 aa)
ADJ61832.1Hemolysin activation/secretion protein. (569 aa)
exbDBiopolymer transport ExbD/TolR protein. (135 aa)
ADJ61818.1TonB domain protein. (236 aa)
ADJ61816.1MotA/TolQ/ExbB proton channel family protein. (208 aa)
ADJ61805.1VGR-related protein. (912 aa)
ADJ61776.1VGR-related protein. (966 aa)
gspGGeneral secretion pathway protein. (183 aa)
secBPreprotein translocase subunit SecB protein; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (164 aa)
secYPreprotein translocase SecY transmembrane protein; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
secEPreprotein translocase SecE subunit transmembrane protein; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (126 aa)
gshAGlutamate-cysteine ligase protein. (433 aa)
ADJ61550.1VGR-related protein. (913 aa)
Your Current Organism:
Herbaspirillum seropedicae
NCBI taxonomy Id: 757424
Other names: H. seropedicae SmR1, Herbaspirillum seropedicae SmR1, Herbaspirillum seropedicae str. SmR1, Herbaspirillum seropedicae strain SmR1
Server load: low (32%) [HD]