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| | gpt | Xanthine-guanine phosphoribosyltransferase protein. (177 aa) |
| | ndk | Nucleoside-diphosphate kinase protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | rpoS | RNA polymerase sigma S (sigma38) factor protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (337 aa) |
| | mmyX | ATP/GTP-binding protein. (225 aa) |
| | rpoE-5 | RNA polymerase sigma-70 factor, ECF subfamily (sigma-24) transcription regulator protein. (195 aa) |
| | ADJ64568.1 | GNAT family acetyltransferase protein. (159 aa) |
| | cysG | uroporphyrinogen-III C-methyltransferase protein; Belongs to the precorrin methyltransferase family. (253 aa) |
| | ADJ64590.1 | Conserved hypothetical protein; S - Function unknown. (121 aa) |
| | prpE | propionyl-CoA ligase protein. (628 aa) |
| | ADJ64654.1 | Adenylate kinase and related kinases protein. (189 aa) |
| | hemN-2 | Oxygen-independent coproporphyrinogen III oxidase protein; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (483 aa) |
| | yhhQ | Membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (218 aa) |
| | pyrD | Dihydroorotate dehydrogenase protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (354 aa) |
| | rpoE-6 | RNA polymerase sigma-E factor protein; Belongs to the sigma-70 factor family. ECF subfamily. (209 aa) |
| | purF | Glutamine phosphoribosylpyrophosphate amidotransferase protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (506 aa) |
| | folC | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase protein; Belongs to the folylpolyglutamate synthase family. (437 aa) |
| | accD-2 | Acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa) |
| | trpA | Tryptophan synthase (alpha chain) protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa) |
| | trpB | Tryptophan synthase (beta chain) protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (419 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase protein; Belongs to the TrpF family. (222 aa) |
| | aroC | Chorismate synthase protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa) |
| | serA-4 | D-3-phosphoglycerate dehydrogenase protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa) |
| | thiL | Thiamine-monophosphate kinase protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (321 aa) |
| | cinA1 | Competence- and mitomycin-induced protein; Belongs to the CinA family. (160 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase protein; Belongs to the OMP decarboxylase family. Type 2 subfamily. (272 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit, protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (244 aa) |
| | thyA | Thymidylate synthetase protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (323 aa) |
| | folA | Dihydrofolate reductase oxidoreductase protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (164 aa) |
| | dcd | Deoxycytidine triphosphate deaminase protein; Catalyzes the deamination of dCTP to dUTP. (189 aa) |
| | ADJ64946.1 | Plasmid stabilization system protein. (108 aa) |
| | umuC | SOS mutagenesis and repair protein. (162 aa) |
| | ADJ64979.1 | Hypothetical protein; S - Function unknown. (117 aa) |
| | fecI-4 | RNA polymerase sigma-70 factor, ECF subfamily (sigma-24) transcription regulator protein. (178 aa) |
| | purD | Phosphoribosylamine-glycine ligase protein; Belongs to the GARS family. (422 aa) |
| | hemF | Coproporphyrinogen III oxidase protein; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (324 aa) |
| | nadD | Nicotinic acid mononucleotide adenylyltransferase protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (221 aa) |
| | dnaE-2 | DNA polymerase III (alpha chain) protein. (1152 aa) |
| | nusB | Transcription antiterminator (L factor) transcription regulator protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (156 aa) |
| | nusA | Transcription elongation factor protein; Participates in both transcription termination and antitermination. (519 aa) |
| | dnaX | DNA polymerase III (subunits tau and gamma) protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (712 aa) |
| | ugdH | UDP-glucose 6-dehydrogenase protein. (459 aa) |
| | cmk | Cytidylate kinase protein. (222 aa) |
| | aroA | 5-enolpyruvylshikimate-3-phosphate synthase (EPSP synthase) protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (445 aa) |
| | tyrA | Prephenate dehydrogenase protein. (295 aa) |
| | ADJ65171.1 | Bifunctional enzyme: chorismate mutase/prephenate dehydratase protein. (377 aa) |
| | serC | Phosphoserine aminotransferase protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (370 aa) |
| | aroE-2 | Shikimate 5-dehydrogenase protein. (281 aa) |
| | ADJ65308.1 | Conserved hypothetical protein; S - Function unknown; Belongs to the Cob(I)alamin adenosyltransferase family. (185 aa) |
| | dxs | 1-deoxy-D-xylulose 5-phosphate synthase protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa) |
| | thiD-2 | Phosphomethylpyrimidine kinase protein. (282 aa) |
| | hemL | Glutamate-1-semialdhyde 2,1-aminomutase protein. (427 aa) |
| | pyrC | Dihydroorotase protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa) |
| | apaG | Mg2+/Co2+ transport regulator of protein. (124 aa) |
| | trpE | Anthranilate synthase component I protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high [...] (498 aa) |
| | trpD-2 | Anthranilate phosphoribosyltransferase protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | trpC | Indole-3-glycerol phosphate synthase 1 protein; Belongs to the TrpC family. (266 aa) |
| | queF | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (291 aa) |
| | ADJ65389.1 | FOG: TPR repeat containing protein. (600 aa) |
| | prsA | Phosphoribosylpyrophosphate synthetase protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | amn | AMP nucleosidase protein; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (502 aa) |
| | rpoN | RNA polymerase sigma-N (sigma-54) factor transcription regulator protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (496 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (416 aa) |
| | ADJ65607.1 | SAM-dependent methyltransferase protein. (299 aa) |
| | kdtB | Phosphopantetheine adenylyltransferase (pantetheine-Phosphate adenylyltransferase) protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | rpoH | RNA polymerase sigma-32 factor protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (299 aa) |
| | ctaB | Protoheme IX farnesyltransferase (heme O synthase) transmembrane protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (297 aa) |
| | ctaA | Heme O oxygenase (cytochrome aa3-controlling) transmembrane protein. (378 aa) |
| | queC | PP-loop superfamily ATPase protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (263 aa) |
| | aroBK | Bifunctional enzyme: 3-dehydroquinate synthase/shikimate kinase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (596 aa) |
| | rfbD | dTDP-4-dehydrorhamnose reductase protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (285 aa) |
| | add | Adenosine deaminase protein; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (352 aa) |
| | hemA | glutamyl-tRNA reductase protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (430 aa) |
| | phhA | Phenylalanine 4-hydroxylase oxidoreductase protein. (295 aa) |
| | ADJ65755.1 | 5-formyltetrahydrofolate cyclo-ligase protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (210 aa) |
| | coaX | Transcription regulation accessory factor transcription regulator protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (258 aa) |
| | serA-5 | D-3-phosphoglycerate dehydrogenase protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa) |
| | dinP | nucleotidyltransferase/DNA polymerase involved in DNA repair protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (384 aa) |
| | ADJ65815.1 | Conserved hypothetical protein; S - Function unknown. (108 aa) |
| | priA | Primosomal protein N' (replication factor Y)- superfamily II helicase protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (708 aa) |
| | hemE | Uroporphyrinogen decarboxylase protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (364 aa) |
| | atpC | F0F1-type ATP synthase, epsilon subunit protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa) |
| | atpD | F0F1-type ATP synthase, beta subunit protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (466 aa) |
| | atpG | F0F1-type ATP synthase, gamma subunit protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (290 aa) |
| | atpA | F0F1-type ATP synthase, alpha subunit protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | atpH | F0F1-type ATP synthase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa) |
| | atpF | F0F1-type ATP synthase, subunit b protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpE | F0F1-type ATP synthase, subunit c protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa) |
| | atpB | F0F1-type ATP synthase, subunit a protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (273 aa) |
| | ADJ65840.1 | dTDP-4-dehydrorhamnose reductase protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (312 aa) |
| | rfbC | dTDP-6-deoxy-D-glucose-3,5 epimerase protein; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa) |
| | ADJ65880.1 | Galactokinase/mevalonate kinase protein. (332 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (452 aa) |
| | serA-6 | D-3-phosphoglycerate dehydrogenase protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (308 aa) |
| | fecI-5 | RNA polymerase sigma-70 factor, ECF subfamily (sigma-24) transcription regulator protein. (169 aa) |
| | murA-2 | UDP-N-acetylglucosamine enolpyruvyl transferase protein. (433 aa) |
| | gloA-4 | Lactoylglutathione lyase protein. (125 aa) |
| | fecI-6 | RNA polymerase sigma-70 factor, ECF subfamily (sigma-24) transcription regulator protein. (178 aa) |
| | nadE-2 | NH(3)-dependent NAD(+) synthetase protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (565 aa) |
| | pncB-2 | Nicotinic acid phosphoribosyltransferase protein; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (400 aa) |
| | pyrE | Orotate phosphoribosyltransferase protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (219 aa) |
| | ADJ66147.1 | L-aspartate dehydrogenase protein. (257 aa) |
| | folE | GTP cyclohydrolase I protein. (254 aa) |
| | dnaN | DNA polymerase III subunit beta protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] (368 aa) |
| | ADJ61536.1 | Reverse transcriptase of bacterial retrotransposons protein. (1022 aa) |
| | acs | Acetyl-coenzyme A synthetase protein. (549 aa) |
| | fecI | RNA polymerase sigma-70 factor protein; ECF subfamily (sigma-24) transcription regulator; Belongs to the sigma-70 factor family. ECF subfamily. (181 aa) |
| | nusG | Transcription antitermination protein; Participates in transcription elongation, termination and antitermination. (196 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1368 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1413 aa) |
| | rpoA | DNA-directed RNA polymerase alpha chain protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (325 aa) |
| | rpoE | RNA polymerase sigma-24 factor protein; Belongs to the sigma-70 factor family. (324 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase protein; Belongs to the ALAD family. (339 aa) |
| | pta | Phosphate acetyltransferase protein. (319 aa) |
| | ackA | Acetate kinase protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa) |
| | cyaA | Adenylate cyclase protein. (757 aa) |
| | coaE | dephospho-CoA kinase protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | nrdA | Ribonucleoside reductase (large chain) oxidoreductase protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (994 aa) |
| | nrdB | Transmembrane ribonucleoside reductase (small chain) protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (388 aa) |
| | accC | Biotin carboxylase protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (459 aa) |
| | aroQ | 3-dehydroquinate dehydratase protein; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa) |
| | aroE | Shikimate 5-dehydrogenase protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | purH | Bifunctional enzyme: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase transmembrane protein. (523 aa) |
| | thiC | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (637 aa) |
| | thiG | Thiamine (thiazole ring) biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (269 aa) |
| | thiD | Phosphomethylpyrimidine kinase protein. (288 aa) |
| | thiE | Thiamine monophosphate synthase protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (210 aa) |
| | polA | DNA polymerase I protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (920 aa) |
| | ADJ61989.1 | Transcription regulator protein; Belongs to the UPF0301 (AlgH) family. (193 aa) |
| | pyrB | Aspartate carbamoyltransferase (catalytic chain) protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (319 aa) |
| | pyrX | Dihydroorotase protein. (428 aa) |
| | ADJ62110.1 | Inner membrane protein. (141 aa) |
| | holA | DNA polymerase III (delta subunit) protein. (339 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (305 aa) |
| | hemH | Ferrochelatase (protoheme ferro-lyase) protein; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (369 aa) |
| | ADJ62137.1 | Deoxynucleoside kinase protein. (213 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase protein. (161 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase (AirS) protein. (347 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase protein; Belongs to the SAICAR synthetase family. (298 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (401 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase protein; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (212 aa) |
| | purB | Adenylosuccinate lyase protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa) |
| | upp | Uracil phosphoribosyltransferase protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (215 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase protein; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (340 aa) |
| | corC | Mg2+ and Co2+ transporter protein. (292 aa) |
| | ADJ62245.1 | Panthothenate kinase protein. (204 aa) |
| | hrpL | RNA polymerase sigma-24 factor protein; Belongs to the sigma-70 factor family. ECF subfamily. (244 aa) |
| | hrcN | Type III secretion ATP synthase protein. (460 aa) |
| | ADJ62338.1 | Conserved hypothetical protein; S - Function unknown. (184 aa) |
| | fdx | Ferredoxin [4Fe-4S]-type protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (347 aa) |
| | trpD | Anthranilate phosphoribosyltransferase protein. (336 aa) |
| | rho | Transcription termination factor Rho protein; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (420 aa) |
| | dnaG | DNA primase protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (598 aa) |
| | rpoD | RNA polymerase sigma-70 factor transcription regulator protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (850 aa) |
| | acs-2 | Acetyl-coenzyme A synthetase protein. (556 aa) |
| | ADJ62576.1 | Conserved hypothetical protein; S - Function unknown. (139 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase protein; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (271 aa) |
| | adk | Adenylate kinase (ATP-AMP transphosphorylase) protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (203 aa) |
| | tsaA | S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase)protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (338 aa) |
| | tgt | Queuine tRNA-ribosyltransferase protein; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose t [...] (376 aa) |
| | ADJ62851.1 | MobA-related protein. (205 aa) |
| | glcG | Glycolate/propanediol utilization protein. (135 aa) |
| | carA | Carbamoyl-phosphate synthase (small chain) protein; Belongs to the CarA family. (387 aa) |
| | carB | Carbamoyl-phosphate synthase (large chain) protein; Belongs to the CarB family. (1077 aa) |
| | folP | 7,8-dihydropteroate synthase protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa) |
| | coaBC | Phosphopantothenoylcysteine synthetase/decarboxylase protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (398 aa) |
| | ribF | Riboflavin biosynthesis protein; Belongs to the ribF family. (325 aa) |
| | aroG | 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (357 aa) |
| | ADJ62948.1 | Pterin-4-alpha-carbinolamine dehydratase protein. (118 aa) |
| | holC | DNA polymerase III (chi subunit) protein. (139 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa) |
| | cobD | Cobalamin biosynthesis transmembrane protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (319 aa) |
| | acs-3 | Acetyl-coenzyme A synthetase protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | purU | Formyltetrahydrofolate deformylase protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa) |
| | pncB | Nicotinate phosphoribosyltransferase protein; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (402 aa) |
| | moeA | Molybdopterin biosynthesis enzyme protein. (268 aa) |
| | selA | Selenocysteine synthase [seryl-tRNASer selenium transferase] protein. (392 aa) |
| | ADJ63235.1 | Conserved hypothetical protein; S - Function unknown. (179 aa) |
| | fecI-2 | RNA polymerase sigma-70 factor, ECF subfamily (sigma-24) transcription regulator protein. (192 aa) |
| | ADJ63317.1 | Hemolysin-adenylate cyclase protein. (2656 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase (alpha subunit) protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (326 aa) |
| | nadE | Glutamine-dependent NAD synthetase protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (685 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (433 aa) |
| | rpoE-2 | RNA polymerase sigma-E factor (sigma-24) transcription regulator protein; Belongs to the sigma-70 factor family. ECF subfamily. (200 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (257 aa) |
| | cobT | nicotinate-nucleotide-dimethylbenzimidazole-P phosphoribosyltransferase protein; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (344 aa) |
| | cobS | Cobalamin-5-phosphate synthase protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (274 aa) |
| | ugd | UDP-glucose 6-dehydrogenase protein. (458 aa) |
| | fliA | RNA polymerase sigma factor for flagellar operon (sigma-F factor) protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (244 aa) |
| | fliI | Flagellum-specific ATP synthase protein. (468 aa) |
| | priB | Primosomal replication N protein; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (99 aa) |
| | dnaB | Replicative DNA helicase protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (478 aa) |
| | rpoZ | DNA-directed RNA polymerase omega subunit protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (67 aa) |
| | gmk | Guanylate kinase (GMP kinase) protein; Essential for recycling GMP and indirectly, cGMP. (212 aa) |
| | hemN | Anaerobic coproporphyrinogen III oxidase oxidoreductase protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (414 aa) |
| | pyrH | Uridylate kinase protein; Catalyzes the reversible phosphorylation of UMP to UDP. (238 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa) |
| | guaA | GMP synthase protein; Catalyzes the synthesis of GMP from XMP. (530 aa) |
| | queE | Organic radical activating enzyme protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (229 aa) |
| | ADJ63710.1 | 6-pyruvoyl-tetrahydropterin synthase protein. (148 aa) |
| | nadA | Quinolinate synthetase A protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (379 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase protein; Belongs to the NadC/ModD family. (301 aa) |
| | nadB | L-aspartate oxidase (quinolinate synthetase B) protein; Catalyzes the oxidation of L-aspartate to iminoaspartate. (534 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2 protein; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (403 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase protein; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1341 aa) |
| | ADJ63743.1 | Stress-induced morphogen protein; Belongs to the BolA/IbaG family. (94 aa) |
| | dnaE | DNA polymerase III, alpha subunit protein; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (942 aa) |
| | ADJ63770.1 | ATP-dependent DNA ligase protein. (856 aa) |
| | ADJ63777.1 | ATP-dependent DNA ligase protein. (555 aa) |
| | cinA2 | Competence- and mitomycin-induced protein; Belongs to the CinA family. (165 aa) |
| | pfrI | Ferric regulator sigma-24 subunit protein; Belongs to the sigma-70 factor family. ECF subfamily. (178 aa) |
| | ADJ63873.1 | Hypothetical protein; S - Function unknown. (119 aa) |
| | ADJ63882.1 | DNA polymerase IV protein. (593 aa) |
| | ADJ63906.1 | Phosphate acetyl/butaryl transferase protein. (484 aa) |
| | rpoE-3 | RNA polymerase sigma-E factor protein; Belongs to the sigma-70 factor family. ECF subfamily. (186 aa) |
| | fecI-3 | RNA polymerase sigma-70 factor, ECF subfamily (sigma-24) transcription regulator protein. (174 aa) |
| | polB | DNA polymerase II protein. (790 aa) |
| | folE2 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (303 aa) |
| | holB | DNA polymerase III delta subunit protein. (345 aa) |
| | tmk | Thymidylate kinase protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (202 aa) |
| | ADJ64116.1 | Acetyltransferase protein. (146 aa) |
| | cobQ | Cobyric acid synthase protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (489 aa) |
| | cobC | Cobalamin biosynthesis protein. (336 aa) |
| | cobD-2 | Cobalamin biosynthesis (CobD/CbiB) protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (317 aa) |
| | cobP | Bifunctional enzyme: cobinamide kinase/cobinamide phosphate guanylyltransferase protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (204 aa) |
| | nfnB | Oxygen-insensitive nitroreductase protein. (220 aa) |
| | cobB | Cobyrinic acid A,c-diamide synthase protein; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (444 aa) |
| | cobA | cob(I)alamin adenosyltransferase protein; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (200 aa) |
| | cbiJH | Bifunctional: precorrin-3 methyltransferase and precorrin-6x reductase oxidoreductase protein. (519 aa) |
| | cbiG | Bifunctional precorrin-3B C17-methyltransferase/precorrin isomerase protein. (267 aa) |
| | cbiF | Precorrin-4 C11-methyltransferase protein; Belongs to the precorrin methyltransferase family. (258 aa) |
| | cbiL | Precorrin-2 C20-methyltransferase protein; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. (256 aa) |
| | cbiD | Cobalamin biosynthesis CbiD transmembrane protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (396 aa) |
| | cobH | precorrin-8X methylmutase protein. (525 aa) |
| | cobL | Precorrin-6y methylase methyltransferase protein. (241 aa) |
| | chlI | Mg-chelatase subunit ChlI protein. (663 aa) |
| | accD | acetyl-CoA carboxylase beta subunit protein. (298 aa) |
| | rpoE-4 | RNA polymerase sigma-E factor (sigma-24) protein; Belongs to the sigma-70 factor family. ECF subfamily. (163 aa) |
| | pyrG | CTP synthase (UTP-ammonia lyase) protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (556 aa) |
| | prhI | RNA polymerase sigma 24 factor protein; Belongs to the sigma-70 factor family. ECF subfamily. (173 aa) |
| | nifK | Nitrogenase molybdenum-iron protein beta chain protein; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation; Belongs to the NifD/NifK/NifE/NifN family. (519 aa) |
| | nifH | Dinitrogenase reductase protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (292 aa) |
| | ADJ64393.1 | Retron reverse transcriptase protein. (344 aa) |
| | hemY | Porphyrin biosynthesis protein. (399 aa) |
| | hemD | uroporphyrinogen-III synthase protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (269 aa) |
| | hemC | Porphobilinogen deaminase protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (318 aa) |
| | purA | Adenylosuccinate synthetase protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (437 aa) |
