STRINGSTRING
ileS_1 ileS_1 glyQ glyQ glyS glyS priA_1 priA_1 bolA bolA leuS_1 leuS_1 holA_1 holA_1 trpS trpS purB_1 purB_1 NCTC8284_02631 NCTC8284_02631 yfbR_1 yfbR_1 ribD ribD gshAB_2 gshAB_2 kdsB_1 kdsB_1 folK folK serC_1 serC_1 serS_1 serS_1 rpoE_3 rpoE_3 dnaX_2 dnaX_2 apt apt valS_2 valS_2 holC holC NCTC8284_02869 NCTC8284_02869 rimK_2 rimK_2 manA_2 manA_2 guaB guaB guaA_1 guaA_1 pth pth murZ_2 murZ_2 corC corC D3M82_03380 D3M82_03380 hisS hisS rpmH rpmH dnaN_1 dnaN_1 nudB nudB aspS aspS NCTC8284_01282 NCTC8284_01282 accA accA pdxY_1 pdxY_1 purM_2 purM_2 purN purN yjeA yjeA ndk_1 ndk_1 rho_4 rho_4 dnaB2 dnaB2 prs_2 prs_2 thiM thiM thiD thiD thiE thiE ribE ribE rplY rplY accD_1 accD_1 folC_2 folC_2 dinB_2 dinB_2 prfA_2 prfA_2 bioA_1 bioA_1 bioF_2 bioF_2 bioC_1 bioC_1 bioD2_2 bioD2_2 pyrD pyrD pyrF_2 pyrF_2 glnS_2 glnS_2 rpsA_5 rpsA_5 cmk cmk prfB_2 prfB_2 lysS lysS purU purU argS_1 argS_1 sgbH1_2 sgbH1_2 nrdB nrdB folE folE hpt hpt purF_1 purF_1 ackA ackA pta_2 pta_2 hemL_1 hemL_1 rpsO rpsO hldE_1 hldE_1 bioB_2 bioB_2 hemH_2 hemH_2 nrdG nrdG cysS_4 cysS_4 GCA_000730685_01279 GCA_000730685_01279 ppnK_1 ppnK_1 udk udk dcd dcd holD holD ribA ribA purC_2 purC_2 prfC_1 prfC_1 hemA_2 hemA_2 spoT_1 spoT_1 rpoZ rpoZ gmk_1 gmk_1 upp upp ribH_2 ribH_2 nusB nusB thiL_2 thiL_2 folP folP asnC_1 asnC_1 pheS_2 pheS_2 pheT_1 pheT_1 rplM rplM rpsI rpsI trpA_2 trpA_2 trpB_2 trpB_2 trpC trpC trpD trpD yigB yigB yhhQ yhhQ efp efp rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV_2 rplV_2 rpsS rpsS rplB rplB rplW_2 rplW_2 rplD_1 rplD_1 rplC_1 rplC_1 rpsJ rpsJ ribB ribB nadR_1 nadR_1 coaD coaD rplA rplA rplK_2 rplK_2 nusG_1 nusG_1 cya_3 cya_3 alaS_3 alaS_3 rplQ rplQ rpoA_2 rpoA_2 rpsD rpsD rpsK rpsK GCA_000730685_01713 GCA_000730685_01713 rpmJ rpmJ rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE_1 rplE_1 rplX_2 rplX_2 rplN rplN purL_2 purL_2 proS_2 proS_2 asnA asnA hemN_3 hemN_3 rfaD_1 rfaD_1 cof_2 cof_2 tufA1_1 tufA1_1 coaA_1 coaA_1 udp udp ggt_1 ggt_1 atpB_2 atpB_2 atpE atpE atpF atpF atpH_2 atpH_2 atpA atpA atpG atpG atpD atpD atpC atpC tmk tmk holB_1 holB_1 rpoE_2 rpoE_2 purT_1 purT_1 rplJ rplJ rplL rplL rpoB_2 rpoB_2 rpoC rpoC gpt_1 gpt_1 dnaE_2 dnaE_2 def_2 def_2 fmt fmt pdxH pdxH rpsL rpsL rpsG_2 rpsG_2 fusA fusA GCA_000730685_02028 GCA_000730685_02028 hemC hemC hemD_1 hemD_1 hemY_1 hemY_1 selA selA selB_3 selB_3 hemG hemG hemN_1 hemN_1 tdk tdk rpsU rpsU dnaG_2 dnaG_2 rpoD_1 rpoD_1 rpsB_1 rpsB_1 tsf_1 tsf_1 pyrH_2 pyrH_2 frr frr NCTC8284_03724 NCTC8284_03724 NCTC8284_03714 NCTC8284_03714 polA_1 polA_1 NCTC8284_03665 NCTC8284_03665 folA folA hemB_1 hemB_1 GCA_000730685_02155 GCA_000730685_02155 rplS rplS NCTC8284_03627 NCTC8284_03627 GCA_000730685_02208 GCA_000730685_02208 ribF ribF ileS_4 ileS_4 GCA_000730685_02215 GCA_000730685_02215 GCA_000730685_02217 GCA_000730685_02217 GCA_000730685_02220 GCA_000730685_02220 GCA_000730685_02253 GCA_000730685_02253 GCA_000730685_02254 GCA_000730685_02254 GCA_000730685_02288 GCA_000730685_02288 trpE_2 trpE_2 thrS_2 thrS_2 nusA_3 nusA_3 infB_2 infB_2 adk_1 adk_1 rpmF rpmF pyrE_2 pyrE_2 GCA_000730685_00533 GCA_000730685_00533 folD folD infA infA rpsF rpsF priB priB rpsR rpsR rplI rplI folB folB rpoH rpoH hemE hemE pyrG pyrG glmU_2 glmU_2 queA_2 queA_2 tgt tgt purD_3 purD_3 purH_2 purH_2 smpB smpB GCA_000730685_00603 GCA_000730685_00603 rplU_1 rplU_1 NCTC8284_00913 NCTC8284_00913 gltX_1 gltX_1 rpmE rpmE infC infC rpmL rpmL rplT rplT ybaK_2 ybaK_2 purK_1 purK_1 purE purE purR_2 purR_2 metG_3 metG_3 thiI_2 thiI_2 dxs_1 dxs_1 queF_2 queF_2 NCTC8284_02112 NCTC8284_02112 yciH yciH NCTC8284_01696 NCTC8284_01696 NCTC8284_02505 NCTC8284_02505 BKG95_02555 BKG95_02555 tyrS_4 tyrS_4 purA_2 purA_2 GCA_000730685_00085 GCA_000730685_00085 queC_1 queC_1 queD queD dnaQ_1 dnaQ_1 dut dut coaBC coaBC rpmB rpmB rpmG rpmG NCTC8284_03435 NCTC8284_03435 lepA_4 lepA_4 thyA_1 thyA_1 coaE_2 coaE_2 arfA arfA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ileS_1Unannotated protein. (213 aa)
glyQUnannotated protein. (302 aa)
glySUnannotated protein. (688 aa)
priA_1Unannotated protein. (730 aa)
bolAUnannotated protein; Belongs to the BolA/IbaG family. (103 aa)
leuS_1Unannotated protein. (862 aa)
holA_1Unannotated protein. (344 aa)
trpSUnannotated protein; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa)
purB_1Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa)
NCTC8284_02631Unannotated protein. (209 aa)
yfbR_1Unannotated protein. (197 aa)
ribDUnannotated protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (373 aa)
gshAB_2Unannotated protein; Belongs to the glutamate--cysteine ligase type 1 family. (757 aa)
kdsB_1Unannotated protein; Belongs to the KdsB family. (254 aa)
folKUnannotated protein. (158 aa)
serC_1Unannotated protein. (361 aa)
serS_1Unannotated protein. (429 aa)
rpoE_3Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (182 aa)
dnaX_2Unannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (696 aa)
aptUnannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (180 aa)
valS_2Unannotated protein; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (936 aa)
holCUnannotated protein. (143 aa)
NCTC8284_02869Unannotated protein. (200 aa)
rimK_2Unannotated protein; Belongs to the RimK family. (299 aa)
manA_2Unannotated protein. (399 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
guaA_1Unannotated protein. (519 aa)
pthUnannotated protein; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (194 aa)
murZ_2Unannotated protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (426 aa)
corCUnannotated protein. (297 aa)
D3M82_03380Unannotated protein. (111 aa)
hisSUnannotated protein. (423 aa)
rpmHUnannotated protein; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
dnaN_1Unannotated protein. (366 aa)
nudBUnannotated protein. (162 aa)
aspSUnannotated protein; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (588 aa)
NCTC8284_01282Unannotated protein. (194 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (315 aa)
pdxY_1Unannotated protein. (288 aa)
purM_2Unannotated protein. (345 aa)
purNUnannotated protein. (213 aa)
yjeAUnannotated protein. (327 aa)
ndk_1Unannotated protein; Belongs to the NDK family. (140 aa)
rho_4Unannotated protein; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (420 aa)
dnaB2Unannotated protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (468 aa)
prs_2Unannotated protein. (315 aa)
thiMUnannotated protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (263 aa)
thiDUnannotated protein. (271 aa)
thiEUnannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (225 aa)
ribEUnannotated protein. (203 aa)
rplYUnannotated protein; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (95 aa)
accD_1Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. Belongs to the AccD/PCCB family. (306 aa)
folC_2Unannotated protein. (434 aa)
dinB_2Unannotated protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (355 aa)
prfA_2Unannotated protein. (360 aa)
bioA_1Unannotated protein. (429 aa)
bioF_2Unannotated protein. (380 aa)
bioC_1Unannotated protein. (257 aa)
bioD2_2Unannotated protein. (213 aa)
pyrDUnannotated protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (339 aa)
pyrF_2Unannotated protein. (231 aa)
glnS_2Unannotated protein. (557 aa)
rpsA_5Unannotated protein. (549 aa)
cmkUnannotated protein. (223 aa)
prfB_2Unannotated protein. (354 aa)
lysSUnannotated protein; Belongs to the class-II aminoacyl-tRNA synthetase family. (502 aa)
purUUnannotated protein. (278 aa)
argS_1Unannotated protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (577 aa)
sgbH1_2Unannotated protein. (226 aa)
nrdBUnannotated protein. (376 aa)
folEUnannotated protein. (218 aa)
hptUnannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
purF_1Unannotated protein. (505 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa)
pta_2Unannotated protein. (712 aa)
hemL_1Unannotated protein. (427 aa)
rpsOUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
hldE_1Unannotated protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (476 aa)
bioB_2Unannotated protein. (337 aa)
hemH_2Unannotated protein; Catalyzes the ferrous insertion into protoporphyrin IX. (323 aa)
nrdGUnannotated protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (156 aa)
cysS_4Unannotated protein. (459 aa)
GCA_000730685_01279Unannotated protein. (92 aa)
ppnK_1Unannotated protein. (296 aa)
udkUnannotated protein. (213 aa)
dcdUnannotated protein; Catalyzes the deamination of dCTP to dUTP. (194 aa)
holDUnannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (134 aa)
ribAUnannotated protein; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (219 aa)
purC_2Unannotated protein. (288 aa)
prfC_1Unannotated protein; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (526 aa)
hemA_2Unannotated protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (439 aa)
spoT_1Unannotated protein. (704 aa)
rpoZUnannotated protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (88 aa)
gmk_1Unannotated protein. (212 aa)
uppUnannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
ribH_2Unannotated protein; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (157 aa)
nusBUnannotated protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (144 aa)
thiL_2Unannotated protein. (332 aa)
folPUnannotated protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (275 aa)
asnC_1Unannotated protein. (467 aa)
pheS_2Unannotated protein. (329 aa)
pheT_1Unannotated protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (795 aa)
rplMUnannotated protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpsIUnannotated protein; Belongs to the universal ribosomal protein uS9 family. (130 aa)
trpA_2Unannotated protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa)
trpB_2Unannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa)
trpCUnannotated protein; Belongs to the TrpF family. (479 aa)
trpDUnannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (333 aa)
yigBUnannotated protein. (234 aa)
yhhQUnannotated protein. (238 aa)
efpUnannotated protein; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation; Belongs to the elongation factor P family. (188 aa)
rpsQUnannotated protein; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (85 aa)
rpmCUnannotated protein; Belongs to the universal ribosomal protein uL29 family. (63 aa)
rplPUnannotated protein; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa)
rpsCUnannotated protein; Belongs to the universal ribosomal protein uS3 family. (235 aa)
rplV_2Unannotated protein; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (110 aa)
rpsSUnannotated protein; Belongs to the universal ribosomal protein uS19 family. (91 aa)
rplBUnannotated protein; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa)
rplW_2Unannotated protein. (99 aa)
rplD_1Unannotated protein. (200 aa)
rplC_1Unannotated protein; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (208 aa)
rpsJUnannotated protein; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
ribBUnannotated protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (215 aa)
nadR_1Unannotated protein. (368 aa)
coaDUnannotated protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
rplAUnannotated protein; Belongs to the universal ribosomal protein uL1 family. (229 aa)
rplK_2Unannotated protein. (142 aa)
nusG_1Unannotated protein; Participates in transcription elongation, termination and antitermination. (185 aa)
cya_3Unannotated protein. (832 aa)
alaS_3Unannotated protein. (875 aa)
rplQUnannotated protein. (127 aa)
rpoA_2Unannotated protein. (327 aa)
rpsDUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa)
rpsKUnannotated protein; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
GCA_000730685_01713Unannotated protein. (118 aa)
rpmJUnannotated protein; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rplOUnannotated protein; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
rpmDUnannotated protein. (59 aa)
rpsEUnannotated protein; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (166 aa)
rplRUnannotated protein; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa)
rplFUnannotated protein; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpsHUnannotated protein; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpsNUnannotated protein; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rplE_1Unannotated protein. (179 aa)
rplX_2Unannotated protein; Belongs to the universal ribosomal protein uL24 family. (103 aa)
rplNUnannotated protein; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa)
purL_2Unannotated protein. (1296 aa)
proS_2Unannotated protein; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacyl [...] (570 aa)
asnAUnannotated protein. (330 aa)
hemN_3Unannotated protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (383 aa)
rfaD_1Unannotated protein. (308 aa)
cof_2Unannotated protein. (272 aa)
tufA1_1Unannotated protein; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa)
coaA_1Unannotated protein. (311 aa)
udpUnannotated protein; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (252 aa)
ggt_1Unannotated protein. (585 aa)
atpB_2Unannotated protein. (262 aa)
atpEUnannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (84 aa)
atpFUnannotated protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa)
atpH_2Unannotated protein; Belongs to the ATPase delta chain family. (181 aa)
atpAUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa)
atpGUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (289 aa)
atpDUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (457 aa)
atpCUnannotated protein. (142 aa)
tmkUnannotated protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa)
holB_1Unannotated protein. (327 aa)
rpoE_2Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa)
purT_1Unannotated protein. (393 aa)
rplJUnannotated protein; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (163 aa)
rplLUnannotated protein. (123 aa)
rpoB_2Unannotated protein; Belongs to the RNA polymerase beta chain family. (1342 aa)
rpoCUnannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1422 aa)
gpt_1Unannotated protein. (155 aa)
dnaE_2Unannotated protein. (1159 aa)
def_2Unannotated protein; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (169 aa)
fmtUnannotated protein; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (319 aa)
pdxHUnannotated protein; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (210 aa)
rpsLUnannotated protein; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa)
rpsG_2Unannotated protein. (156 aa)
fusAUnannotated protein; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (700 aa)
GCA_000730685_02028Unannotated protein. (394 aa)
hemCUnannotated protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa)
hemD_1Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (245 aa)
hemY_1Unannotated protein. (423 aa)
selAUnannotated protein; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (461 aa)
selB_3Unannotated protein. (621 aa)
hemGUnannotated protein. (171 aa)
hemN_1Unannotated protein. (455 aa)
tdkUnannotated protein. (193 aa)
rpsUUnannotated protein; Belongs to the bacterial ribosomal protein bS21 family. (71 aa)
dnaG_2Unannotated protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (594 aa)
rpoD_1Unannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (631 aa)
rpsB_1Unannotated protein; Belongs to the universal ribosomal protein uS2 family. (242 aa)
tsf_1Unannotated protein; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (283 aa)
pyrH_2Unannotated protein. (237 aa)
frrUnannotated protein; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
NCTC8284_03724Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (190 aa)
NCTC8284_03714Unannotated protein. (186 aa)
polA_1Unannotated protein. (932 aa)
NCTC8284_03665Unannotated protein. (188 aa)
folAUnannotated protein. (160 aa)
hemB_1Unannotated protein; Belongs to the ALAD family. (340 aa)
GCA_000730685_02155Unannotated protein. (82 aa)
rplSUnannotated protein; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (116 aa)
NCTC8284_03627Unannotated protein. (559 aa)
GCA_000730685_02208Unannotated protein. (87 aa)
ribFUnannotated protein; Belongs to the ribF family. (312 aa)
ileS_4Unannotated protein. (941 aa)
GCA_000730685_02215Unannotated protein. (302 aa)
GCA_000730685_02217Unannotated protein. (249 aa)
GCA_000730685_02220Unannotated protein. (70 aa)
GCA_000730685_02253Unannotated protein. (474 aa)
GCA_000730685_02254Unannotated protein. (214 aa)
GCA_000730685_02288Unannotated protein. (110 aa)
trpE_2Unannotated protein. (515 aa)
thrS_2Unannotated protein; Belongs to the class-II aminoacyl-tRNA synthetase family. (643 aa)
nusA_3Unannotated protein. (495 aa)
infB_2Unannotated protein; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (842 aa)
adk_1Unannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
rpmFUnannotated protein; Belongs to the bacterial ribosomal protein bL32 family. (56 aa)
pyrE_2Unannotated protein. (213 aa)
GCA_000730685_00533Unannotated protein. (630 aa)
folDUnannotated protein. (284 aa)
infAUnannotated protein; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
rpsFUnannotated protein; Binds together with S18 to 16S ribosomal RNA. (125 aa)
priBUnannotated protein; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (108 aa)
rpsRUnannotated protein; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (76 aa)
rplIUnannotated protein; Binds to the 23S rRNA. (149 aa)
folBUnannotated protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (122 aa)
rpoHUnannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (281 aa)
hemEUnannotated protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa)
pyrGUnannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa)
glmU_2Unannotated protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa)
queA_2Unannotated protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (363 aa)
tgtUnannotated protein; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. [...] (387 aa)
purD_3Unannotated protein. (431 aa)
purH_2Unannotated protein; Belongs to the PurH family. (532 aa)
smpBUnannotated protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (160 aa)
GCA_000730685_00603Unannotated protein. (85 aa)
rplU_1Unannotated protein; This protein binds to 23S rRNA in the presence of protein L20. (122 aa)
NCTC8284_00913Unannotated protein. (241 aa)
gltX_1Unannotated protein; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (477 aa)
rpmEUnannotated protein; Binds the 23S rRNA. (70 aa)
infCUnannotated protein; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (135 aa)
rpmLUnannotated protein; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
rplTUnannotated protein; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa)
ybaK_2Unannotated protein. (159 aa)
purK_1Unannotated protein. (362 aa)
purEUnannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa)
purR_2Unannotated protein. (338 aa)
metG_3Unannotated protein. (682 aa)
thiI_2Unannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (483 aa)
dxs_1Unannotated protein. (617 aa)
queF_2Unannotated protein. (279 aa)
NCTC8284_02112Unannotated protein; Belongs to the NAPRTase family. (493 aa)
yciHUnannotated protein. (106 aa)
NCTC8284_01696Unannotated protein. (556 aa)
NCTC8284_02505Unannotated protein. (216 aa)
BKG95_02555Unannotated protein. (60 aa)
tyrS_4Unannotated protein. (395 aa)
purA_2Unannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
GCA_000730685_00085Unannotated protein. (110 aa)
queC_1Unannotated protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (227 aa)
queDUnannotated protein. (141 aa)
dnaQ_1Unannotated protein. (255 aa)
dutUnannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa)
coaBCUnannotated protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (402 aa)
rpmBUnannotated protein; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
rpmGUnannotated protein; Belongs to the bacterial ribosomal protein bL33 family. (56 aa)
NCTC8284_03435Unannotated protein. (407 aa)
lepA_4Unannotated protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (607 aa)
thyA_1Unannotated protein. (283 aa)
coaE_2Unannotated protein; Belongs to the CoaE family. (206 aa)
arfAUnannotated protein. (81 aa)
Your Current Organism:
Rodentibacter pneumotropicus
NCBI taxonomy Id: 758
Other names: ATCC 35149, CCUG 12398, CIP 66.16, DSM 21403, JCM 14074, LMG 4224, LMG:4224, NCTC 8141, Pasteurella pneumotropica, Pasteurellaceae bacterium Ac63, R. pneumotropicus
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