STRINGSTRING
CTHT_0005320 CTHT_0005320 CTHT_0005410 CTHT_0005410 CTHT_0005510 CTHT_0005510 CTHT_0006260 CTHT_0006260 CTHT_0007290 CTHT_0007290 CTHT_0007600 CTHT_0007600 CTHT_0000720 CTHT_0000720 CTHT_0001580 CTHT_0001580 CTHT_0001730 CTHT_0001730 CTHT_0001890 CTHT_0001890 CTHT_0002300 CTHT_0002300 CTHT_0003070 CTHT_0003070 CTHT_0008920 CTHT_0008920 CTHT_0009450 CTHT_0009450 CTHT_0009490 CTHT_0009490 CTHT_0009670 CTHT_0009670 CTHT_0009770 CTHT_0009770 CTHT_0010120 CTHT_0010120 CTHT_0011090 CTHT_0011090 CTHT_0011690 CTHT_0011690 CTHT_0011720 CTHT_0011720 CTHT_0013780 CTHT_0013780 CTHT_0013800 CTHT_0013800 CTHT_0013850 CTHT_0013850 CTHT_0014570 CTHT_0014570 CTHT_0015550 CTHT_0015550 CTHT_0015990 CTHT_0015990 CTHT_0016590 CTHT_0016590 CTHT_0016610 CTHT_0016610 FEN1 FEN1 CTHT_0016920 CTHT_0016920 CTHT_0017360 CTHT_0017360 CTHT_0017720 CTHT_0017720 CTHT_0017920 CTHT_0017920 CTHT_0018940 CTHT_0018940 CTHT_0019090 CTHT_0019090 CTHT_0019560 CTHT_0019560 CTHT_0030410 CTHT_0030410 CTHT_0039220 CTHT_0039220 CTHT_0031400 CTHT_0031400 CTHT_0023200 CTHT_0023200 CTHT_0023310 CTHT_0023310 CTHT_0023400 CTHT_0023400 CTHT_0032510 CTHT_0032510 CTHT_0033210 CTHT_0033210 CTHT_0033380 CTHT_0033380 CTHT_0033440 CTHT_0033440 CTHT_0025310 CTHT_0025310 CTHT_0025350 CTHT_0025350 CTHT_0034040 CTHT_0034040 CTHT_0034110 CTHT_0034110 CTHT_0034200 CTHT_0034200 CTHT_0026720 CTHT_0026720 CTHT_0035510 CTHT_0035510 CTHT_0027050 CTHT_0027050 CTHT_0027840 CTHT_0027840 CTHT_0028340 CTHT_0028340 CTHT_0036860 CTHT_0036860 CTHT_0036990 CTHT_0036990 CTHT_0028550 CTHT_0028550 CTHT_0028750 CTHT_0028750 CTHT_0029130 CTHT_0029130 CTHT_0037700 CTHT_0037700 CTHT_0038420 CTHT_0038420 CTHT_0038710 CTHT_0038710 CTHT_0038760 CTHT_0038760 CTHT_0043720 CTHT_0043720 CTHT_0040660 CTHT_0040660 CTHT_0041150 CTHT_0041150 CTHT_0042860 CTHT_0042860 CTHT_0042950 CTHT_0042950 CTHT_0048980 CTHT_0048980 CTHT_0049220 CTHT_0049220 CTHT_0053610 CTHT_0053610 CTHT_0054330 CTHT_0054330 CTHT_0057150 CTHT_0057150 MCM7 MCM7 CTHT_0057300 CTHT_0057300 CTHT_0057730 CTHT_0057730 CTHT_0058080 CTHT_0058080 CTHT_0058990 CTHT_0058990 CTHT_0050720 CTHT_0050720 CTHT_0051140 CTHT_0051140 CTHT_0051460 CTHT_0051460 CTHT_0051760 CTHT_0051760 CTHT_0052790 CTHT_0052790 CTHT_0053130 CTHT_0053130 CTHT_0053560 CTHT_0053560 CTHT_0062790 CTHT_0062790 CTHT_0063200 CTHT_0063200 CTHT_0063300 CTHT_0063300 CTHT_0063600 CTHT_0063600 CTHT_0059910 CTHT_0059910 CTHT_0059990 CTHT_0059990 CTHT_0061000 CTHT_0061000 CTHT_0061010 CTHT_0061010 CTHT_0061140 CTHT_0061140 CTHT_0061450 CTHT_0061450 CTHT_0061470 CTHT_0061470 CTHT_0071560 CTHT_0071560 CTHT_0071590 CTHT_0071590 CTHT_0071770 CTHT_0071770 CTHT_0071800 CTHT_0071800 CTHT_0072060 CTHT_0072060 CTHT_0065080 CTHT_0065080 CTHT_0066350 CTHT_0066350 CTHT_0066530 CTHT_0066530 CTHT_0066560 CTHT_0066560 CTHT_0067080 CTHT_0067080 CTHT_0067670 CTHT_0067670 CTHT_0068380 CTHT_0068380 CTHT_0069650 CTHT_0069650 CTHT_0069830 CTHT_0069830 CTHT_0073480 CTHT_0073480 CTHT_0073630 CTHT_0073630
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTHT_0005320Uncharacterized protein. (156 aa)
CTHT_0005410WD_REPEATS_REGION domain-containing protein. (871 aa)
CTHT_0005510DNA repair protein (Rad57)-like protein. (576 aa)
CTHT_0006260AAA_16 domain-containing protein. (529 aa)
CTHT_0007290Nuclease-like protein. (922 aa)
CTHT_0007600Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (730 aa)
CTHT_0000720DNA replication factor C-like protein. (388 aa)
CTHT_0001580Uncharacterized protein. (365 aa)
CTHT_0001730Uncharacterized protein. (196 aa)
CTHT_0001890ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (421 aa)
CTHT_0002300DNA polymerase iota-like protein. (756 aa)
CTHT_0003070Putative checkpoint protein. (970 aa)
CTHT_0008920Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (780 aa)
CTHT_0009450Putative origin recognition complex protein. (707 aa)
CTHT_0009490Replication factor C subunit 2-like protein. (384 aa)
CTHT_0009670Uncharacterized protein. (1261 aa)
CTHT_0009770DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (354 aa)
CTHT_0010120Putative mismatched DNA binding protein. (666 aa)
CTHT_0011090Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (473 aa)
CTHT_0011690DNA polymerase eta-like protein. (507 aa)
CTHT_0011720Protein kinase domain-containing protein. (721 aa)
CTHT_0013780AAA domain-containing protein. (352 aa)
CTHT_0013800Replication factor C subunit 1. (1041 aa)
CTHT_0013850Protein kinase domain-containing protein. (806 aa)
CTHT_0014570Uncharacterized protein. (2963 aa)
CTHT_0015550DNA mismatch repair protein (Mlh3)-like protein. (712 aa)
CTHT_0015990WLM domain-containing protein. (387 aa)
CTHT_0016590DNA primase; Belongs to the eukaryotic-type primase small subunit family. (537 aa)
CTHT_0016610DNA mismatch repair protein msh2-like protein; Component of the post-replicative DNA mismatch repair system (MMR). (940 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
CTHT_0016920RMI1_N domain-containing protein. (285 aa)
CTHT_00173605'->3' double-stranded DNA exonuclease-like protein. (743 aa)
CTHT_0017720DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1238 aa)
CTHT_0017920Zn(2)-C6 fungal-type domain-containing protein. (1178 aa)
CTHT_0018940DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2271 aa)
CTHT_0019090DNA ligase. (837 aa)
CTHT_0019560DNA replication complex GINS protein psf3-like protein. (196 aa)
CTHT_0030410Uncharacterized protein. (894 aa)
CTHT_0039220DNA helicase; Belongs to the MCM family. (982 aa)
CTHT_0031400Serine/threonine-protein kinase-like protein. (760 aa)
CTHT_0023200Serine/threonine protein kinase-like protein; Belongs to the protein kinase superfamily. (472 aa)
CTHT_0023310Uncharacterized protein. (417 aa)
CTHT_0023400Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2925 aa)
CTHT_0032510SAP domain-containing protein. (1710 aa)
CTHT_0033210PHD-type domain-containing protein. (1142 aa)
CTHT_0033380Putative DNA mismatch repair protein. (732 aa)
CTHT_0033440Uncharacterized protein. (273 aa)
CTHT_0025310ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (652 aa)
CTHT_0025350DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (625 aa)
CTHT_0034040Uncharacterized protein. (414 aa)
CTHT_0034110DNA helicase; Belongs to the MCM family. (899 aa)
CTHT_0034200DNA mismatch repair protein pms1-like protein. (1018 aa)
CTHT_0026720DNA ligase. (1032 aa)
CTHT_0035510DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (253 aa)
CTHT_0027050DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (419 aa)
CTHT_0027840Putative DNA damage protein. (1042 aa)
CTHT_0028340Putative specific transcriptional repressor protein. (835 aa)
CTHT_0036860HORMA domain-containing protein. (442 aa)
CTHT_0036990zf-C2HE domain-containing protein. (302 aa)
CTHT_0028550DNA helicase; Belongs to the MCM family. (702 aa)
CTHT_0028750DNA polymerase. (1108 aa)
CTHT_0029130Uncharacterized protein. (1212 aa)
CTHT_0037700Putative chromosome transmission fidelity protein. (1033 aa)
CTHT_0038420Uncharacterized protein. (487 aa)
CTHT_0038710Topoisomerase-like protein. (1887 aa)
CTHT_0038760RECA_2 domain-containing protein. (492 aa)
CTHT_0043720Uncharacterized protein. (844 aa)
CTHT_0040660Hsk1-interacting molecule 1-like protein. (767 aa)
CTHT_0041150ATP-dependent DNA helicase srs2-like protein. (959 aa)
CTHT_0042860DNA replication ATP-dependent helicase dna2-like protein. (1848 aa)
CTHT_0042950Zf-primase domain-containing protein. (1037 aa)
CTHT_0048980DNA repair and recombination protein RAD54-like protein. (838 aa)
CTHT_0049220Protein kinase domain-containing protein. (481 aa)
CTHT_0053610Cell division control protein; Belongs to the CDC6/cdc18 family. (649 aa)
CTHT_0054330Uncharacterized protein. (672 aa)
CTHT_0057150DNA helicase; Belongs to the MCM family. (1017 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (836 aa)
CTHT_0057300DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1151 aa)
CTHT_0057730DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (896 aa)
CTHT_0058080DNA replication complex GINS protein psf1-like protein. (219 aa)
CTHT_0058990BRCT domain-containing protein. (1745 aa)
CTHT_0050720Poly [ADP-ribose] polymerase. (725 aa)
CTHT_0051140DNA polymerase II participates in chromosomal DNA replication-like protein. (831 aa)
CTHT_0051460BRCT domain-containing protein. (313 aa)
CTHT_0051760Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (617 aa)
CTHT_0052790DNA polymerase-like protein. (792 aa)
CTHT_0053130DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1268 aa)
CTHT_0053560DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa)
CTHT_0062790Putative DNA repair and recombination protein. (594 aa)
CTHT_0063200DNA helicase; Belongs to the MCM family. (893 aa)
CTHT_0063300MRC1 domain-containing protein. (1417 aa)
CTHT_0063600SAE2 domain-containing protein. (685 aa)
CTHT_0059910SLD3 domain-containing protein. (1047 aa)
CTHT_0059990Putative sequence-specific DNA binding protein. (357 aa)
CTHT_0061000Vezatin domain-containing protein. (525 aa)
CTHT_0061010Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (306 aa)
CTHT_0061140Uncharacterized protein. (2325 aa)
CTHT_00614503'-5' exonuclease-like protein. (565 aa)
CTHT_0061470DNA polymerase delta small subunit-like protein. (526 aa)
CTHT_0071560DNA polymerase. (1495 aa)
CTHT_0071590RRM domain-containing protein. (306 aa)
CTHT_0071770AAA domain-containing protein. (1275 aa)
CTHT_0071800Uncharacterized protein. (1035 aa)
CTHT_0072060Zn(2)-C6 fungal-type domain-containing protein. (504 aa)
CTHT_0065080Origin recognition complex subunit 2-like protein. (563 aa)
CTHT_0066350DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (626 aa)
CTHT_0066530Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate; Belongs to the ArgJ family. (803 aa)
CTHT_0066560Uncharacterized protein. (322 aa)
CTHT_0067080DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1251 aa)
CTHT_0067670Checkpoint protein; Belongs to the HUS1 family. (368 aa)
CTHT_0068380DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (503 aa)
CTHT_0069650DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (718 aa)
CTHT_0069830DNA ligase. (863 aa)
CTHT_0073480DNA repair exonuclease-like protein. (415 aa)
CTHT_0073630DH domain-containing protein. (1315 aa)
Your Current Organism:
Chaetomium thermophilum
NCBI taxonomy Id: 759272
Other names: C. thermophilum var. thermophilum DSM 1495, Chaetomium thermophilum var. thermophilum DSM 1495
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