STRINGSTRING
CTHT_0000390 CTHT_0000390 ADK1 ADK1 CTHT_0007080 CTHT_0007080 CTHT_0003200 CTHT_0003200 CTHT_0008430 CTHT_0008430 CTHT_0010500 CTHT_0010500 CTHT_0010690 CTHT_0010690 CTHT_0018890 CTHT_0018890 CTHT_0031290 CTHT_0031290 CTHT_0023100 CTHT_0023100 CTHT_0024020 CTHT_0024020 CTHT_0033950 CTHT_0033950 CTHT_0026290 CTHT_0026290 CTHT_0035590 CTHT_0035590 CTHT_0035690 CTHT_0035690 CTHT_0028050 CTHT_0028050 CTHT_0028060 CTHT_0028060 CTHT_0036600 CTHT_0036600 CTHT_0021250 CTHT_0021250 CTHT_0043190 CTHT_0043190 CTHT_0049640 CTHT_0049640 CTHT_0054350 CTHT_0054350 CTHT_0054820 CTHT_0054820 CTHT_0057340 CTHT_0057340 CTHT_0057880 CTHT_0057880 CTHT_0058720 CTHT_0058720 CTHT_0050460 CTHT_0050460 CTHT_0050470 CTHT_0050470 CTHT_0052290 CTHT_0052290 CTHT_0052930 CTHT_0052930 CTHT_0052940 CTHT_0052940 CTHT_0062440 CTHT_0062440 CTHT_0064510 CTHT_0064510 CTHT_0060430 CTHT_0060430 CTHT_0061030 CTHT_0061030 CTHT_0071060 CTHT_0071060 CTHT_0064950 CTHT_0064950 FDH FDH CTHT_0069060 CTHT_0069060 CTHT_0070180 CTHT_0070180 ADK2 ADK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTHT_0000390CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (580 aa)
ADK1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (274 aa)
CTHT_0007080Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (910 aa)
CTHT_0003200AMP deaminase-like protein. (1142 aa)
CTHT_0008430Uncharacterized protein. (291 aa)
CTHT_0010500Formyltetrahydrofolate deformylase-like protein. (285 aa)
CTHT_0010690FSH1 domain-containing protein. (300 aa)
CTHT_0018890Putative 40S ribosomal protein. (1118 aa)
CTHT_0031290Phosphoribosylformylglycinamidine synthase-like protein. (1355 aa)
CTHT_0023100Adenosine kinase-like protein. (348 aa)
CTHT_0024020Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (482 aa)
CTHT_0033950Nucleoside diphosphatase-like protein; Belongs to the GDA1/CD39 NTPase family. (617 aa)
CTHT_0026290Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (423 aa)
CTHT_0035590Glutamine amidotransferase type-1 domain-containing protein. (249 aa)
CTHT_0035690Guanylate kinase-like protein. (197 aa)
CTHT_0028050Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (187 aa)
CTHT_0028060Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (178 aa)
CTHT_0036600GMP synthase [glutamine-hydrolyzing]-like protein. (538 aa)
CTHT_0021250Glutamine amidotransferase type-1 domain-containing protein. (408 aa)
CTHT_0043190Uncharacterized protein. (816 aa)
CTHT_0049640Uncharacterized protein. (108 aa)
CTHT_0054350Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (352 aa)
CTHT_0054820Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (614 aa)
CTHT_0057340Uncharacterized protein. (414 aa)
CTHT_0057880Putative bifunctional purine biosynthesis protein. (593 aa)
CTHT_0058720Pribosyltran domain-containing protein. (229 aa)
CTHT_0050460Uncharacterized protein. (397 aa)
CTHT_0050470Thymidylate kinase-like protein. (296 aa)
CTHT_0052290Deoxycytidylate deaminase-like protein. (369 aa)
CTHT_0052930Putative nickel ion binding protein. (332 aa)
CTHT_0052940Uncharacterized protein. (590 aa)
CTHT_0062440Amidophosphoribosyltransferase. (576 aa)
CTHT_0064510Phosphoribosylaminoimidazole-succinocarboxamide synthase-like protein. (302 aa)
CTHT_0060430Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (543 aa)
CTHT_0061030dUTPase domain-containing protein. (194 aa)
CTHT_0071060Uncharacterized protein. (420 aa)
CTHT_0064950Nucleoside diphosphate kinase. (152 aa)
FDHFormate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. (370 aa)
CTHT_0069060Phosphoribosylglycinamide formyltransferase-like protein. (306 aa)
CTHT_0070180Putative bifunctional purine biosynthetic protein. (786 aa)
ADK2GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (276 aa)
Your Current Organism:
Chaetomium thermophilum
NCBI taxonomy Id: 759272
Other names: C. thermophilum var. thermophilum DSM 1495, Chaetomium thermophilum var. thermophilum DSM 1495
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