(18 nodes) Base excision repair network (Chaetomium thermophilum)

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Your Input:
	CTHT_0001730	Uncharacterized protein. (196 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	CTHT_0018940	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2271 aa)
	CTHT_0019090	DNA ligase. (837 aa)
	CTHT_0034040	Uncharacterized protein. (414 aa)
	CTHT_0028750	DNA polymerase. (1108 aa)
	CTHT_0043920	DNA-(Apurinic or apyrimidinic site) lyase-like protein. (373 aa)
	CTHT_0050080	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (638 aa)
	UNG1	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (390 aa)
	CTHT_0058600	Hydrolase-like protein. (324 aa)
	CTHT_0050720	Poly [ADP-ribose] polymerase. (725 aa)
	CTHT_0051140	DNA polymerase II participates in chromosomal DNA replication-like protein. (831 aa)
	NTH1	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (471 aa)
	CTHT_0063560	ENDO3c domain-containing protein. (374 aa)
	CTHT_0061010	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (306 aa)
	CTHT_0061470	DNA polymerase delta small subunit-like protein. (526 aa)
	CTHT_0067280	DNA (Apurinic or apyrimidinic site) lyase-like protein. (469 aa)
	CTHT_0069830	DNA ligase. (863 aa)

Your Current Organism:

Chaetomium thermophilum

NCBI taxonomy Id: 759272
Other names: C. thermophilum var. thermophilum DSM 1495, Chaetomium thermophilum var. thermophilum DSM 1495

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTHT_0001730	CTHT_0018940	G0RZ52	G0S2Y5	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.707
CTHT_0001730	CTHT_0028750	G0RZ52	G0S7T5	Uncharacterized protein.	DNA polymerase.	0.997
CTHT_0001730	CTHT_0034040	G0RZ52	G0S636	Uncharacterized protein.	Uncharacterized protein.	0.900
CTHT_0001730	CTHT_0061010	G0RZ52	G0SF70	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.971
CTHT_0001730	CTHT_0061470	G0RZ52	G0SFB6	Uncharacterized protein.	DNA polymerase delta small subunit-like protein.	0.997
CTHT_0001730	FEN1	G0RZ52	G0S2B5	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.584
CTHT_0018940	CTHT_0001730	G0S2Y5	G0RZ52	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	Uncharacterized protein.	0.707
CTHT_0018940	CTHT_0019090	G0S2Y5	G0S2Z6	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	DNA ligase.	0.846
CTHT_0018940	CTHT_0028750	G0S2Y5	G0S7T5	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	DNA polymerase.	0.974
CTHT_0018940	CTHT_0034040	G0S2Y5	G0S636	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	Uncharacterized protein.	0.784
CTHT_0018940	CTHT_0050080	G0S2Y5	G0SBF4	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.421
CTHT_0018940	CTHT_0051140	G0S2Y5	G0SDB1	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	DNA polymerase II participates in chromosomal DNA replication-like protein.	0.999
CTHT_0018940	CTHT_0061010	G0S2Y5	G0SF70	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.916
CTHT_0018940	CTHT_0061470	G0S2Y5	G0SFB6	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	DNA polymerase delta small subunit-like protein.	0.959
CTHT_0018940	CTHT_0069830	G0S2Y5	G0SHF4	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	DNA ligase.	0.846
CTHT_0018940	FEN1	G0S2Y5	G0S2B5	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.916
CTHT_0018940	NTH1	G0S2Y5	G0SDQ8	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.466
CTHT_0018940	UNG1	G0S2Y5	G0SCJ1	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.529
CTHT_0019090	CTHT_0018940	G0S2Z6	G0S2Y5	DNA ligase.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.846
CTHT_0019090	CTHT_0028750	G0S2Z6	G0S7T5	DNA ligase.	DNA polymerase.	0.875