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AKA12015.1 AKA12015.1 recG_1 recG_1 htpG htpG trmE trmE obgE obgE lpxH lpxH ppa ppa rppH rppH hflX_1 hflX_1 mutL mutL fusA fusA tuf tuf typA_3 typA_3 hisE hisE ftsZ ftsZ rsgA rsgA uvrD uvrD rep rep ftsY ftsY ruvB ruvB ruvA ruvA apbC apbC copA copA clpB_3 clpB_3 mutT mutT lepA_1 lepA_1 era era rhlB_1 rhlB_1 AKA11090.1 AKA11090.1 AKA12715.1 AKA12715.1 AKA11103.1 AKA11103.1 AKA11134.1 AKA11134.1 AKA11140.1 AKA11140.1 AKA11177.1 AKA11177.1 AKA11229.1 AKA11229.1 AKA11263.1 AKA11263.1 apaH apaH guaA guaA infB_1 infB_1 deaD_2 deaD_2 ppx ppx AKA11414.1 AKA11414.1 mazG_1 mazG_1 mazG_2 mazG_2 uvrB_2 uvrB_2 dnaB_3 dnaB_3 hflB hflB uvrA_1 uvrA_1 dnaB_1 dnaB_1 rarA_2 rarA_2 AKA11749.1 AKA11749.1 hscA hscA recB_5 recB_5 lon lon nudJ nudJ ettA ettA clpX clpX AKA12118.1 AKA12118.1 nudB nudB nudC nudC ychF ychF prfC prfC srmB srmB nudF nudF dut dut helD_1 helD_1 tuf-2 tuf-2 ffh_1 ffh_1 hslU hslU selB_3 selB_3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKA12015.1ABC transporter ATPase; Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (654 aa)
recG_1ATP-dependent DNA helicase RecG; Catalyzes branch migration in Holliday junction intermediates; Derived by automated computational analysis using gene prediction method: Protein Homology. (693 aa)
htpGHeat shock protein 90; Molecular chaperone. Has ATPase activity. (627 aa)
trmEtRNA modification GTPase TrmE; In Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; Derived by automated computational analysis using gene prediction method: Protein Homology. (452 aa)
obgEGTPase CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (388 aa)
lpxHUDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (233 aa)
ppaInorganic pyrophosphatase; Catalyzes the hydrolysis of pyrophosphate to phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
rppHRNA pyrophosphohydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (214 aa)
hflX_1GTPase HflX; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. (461 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (627 aa)
fusAElongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (700 aa)
tufElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa)
typA_3GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology. (615 aa)
hisEphosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the PRA-CH family. (212 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (415 aa)
rsgAGTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (345 aa)
uvrDDNA-dependent helicase II; Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair; Derived by automated computational analysis using gene prediction method: Protein Homology. (732 aa)
repATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (672 aa)
ftsYCell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (498 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
apbCSodium:proton antiporter; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (365 aa)
copAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (730 aa)
clpB_3Protein disaggregation chaperone; Derived by automated computational analysis using gene prediction method: Protein Homology. (855 aa)
mutT8-oxo-dGTP diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
lepA_1Elongation factor 4; Derived by automated computational analysis using gene prediction method: Protein Homology. (597 aa)
eraGTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (305 aa)
rhlB_1RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
AKA11090.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
AKA12715.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
AKA11103.1Host specificity protein J; Derived by automated computational analysis using gene prediction method: Protein Homology. (2349 aa)
AKA11134.1DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
AKA11140.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
AKA11177.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
AKA11229.1DNA packaging protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (703 aa)
AKA11263.1Nucleoside-triphosphate diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
apaHDiadenosine tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (266 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (523 aa)
infB_1Translation initiation factor IF-2; Derived by automated computational analysis using gene prediction method: Protein Homology. (844 aa)
deaD_2DEAD/DEAH box helicase; Participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; Derived by automated computational analysis using gene prediction method: Protein Homology. (602 aa)
ppxExopolyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GppA/Ppx family. (500 aa)
AKA11414.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
mazG_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
mazG_2Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (42 aa)
uvrB_2The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa)
dnaB_3DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (487 aa)
hflBInner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AAA ATPase family. (647 aa)
uvrA_1Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (942 aa)
dnaB_1DNA helicase; Unwinds double stranded DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
rarA_2Recombination factor protein RarA; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
AKA11749.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
hscAChaperone protein HscA; Involved in the maturation of iron-sulfur cluster-containing proteins; Derived by automated computational analysis using gene prediction method: Protein Homology. (617 aa)
recB_5Exodeoxyribonuclease V subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (1174 aa)
lonDNA-binding protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (800 aa)
nudJPhosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. NudJ subfamily. (157 aa)
ettAABC transporter ATP-binding protein; ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; Derived by automated computational analysis using gene prediction method: Protein Homology. (556 aa)
clpXClp protease ClpX; Binds and unfolds substrates as part of the ClpXP protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
AKA12118.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
nudBDihydroneopterin triphosphate pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
nudCNADH pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. NudC subfamily. (253 aa)
ychFGTP-binding protein; EngD; translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
prfCPeptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (526 aa)
srmBATP-dependent RNA helicase SrmB; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily. (444 aa)
nudFADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (151 aa)
helD_1Derived by automated computational analysis using gene prediction method: Protein Homology. (926 aa)
tuf-2Elongation factor Tu; EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
ffh_1Signal recognition particle; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
hslUATP-dependent protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (440 aa)
selB_3Translation elongation factor; Derived by automated computational analysis using gene prediction method: Protein Homology. (615 aa)
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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