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aldA aldA coaBC coaBC dut dut putA putA AKA12503.1 AKA12503.1 iolD_2 iolD_2 iolE iolE mmsA mmsA iolB iolB gabD gabD AKA12576.1 AKA12576.1 kynB kynB garR_2 garR_2 mltC mltC glpK glpK nanE nanE nanK nanK nanA nanA dlgD_1 dlgD_1 glpD glpD udp udp garR_1 garR_1 AKA10265.1 AKA10265.1 uxuA_2 uxuA_2 AKA10327.1 AKA10327.1 yfkN yfkN ulaG ulaG AKA10343.1 AKA10343.1 mtnN_1 mtnN_1 slyX slyX pdxT pdxT pemK pemK rppH rppH AKA10436.1 AKA10436.1 AKA10445.1 AKA10445.1 katA_3 katA_3 yafQ yafQ dtd dtd AKA10487.1 AKA10487.1 surE surE gnd gnd mltF mltF rutB rutB rne rne AKA10654.1 AKA10654.1 rnhB rnhB AKA10706.1 AKA10706.1 hpaC hpaC malS malS AKA10789.1 AKA10789.1 atzC atzC gloA gloA AKA10830.1 AKA10830.1 rdxA rdxA deoC deoC deoD deoD AKA10897.1 AKA10897.1 cdd_1 cdd_1 yafQ_2 yafQ_2 AKA12712.1 AKA12712.1 rhlB_1 rhlB_1 AKA11127.1 AKA11127.1 AKA11156.1 AKA11156.1 AKA11202.1 AKA11202.1 AKA11225.1 AKA11225.1 sucB_2 sucB_2 yhaX yhaX AKA11263.1 AKA11263.1 AKA11284.1 AKA11284.1 rnb_2 rnb_2 csrA csrA AKA11355.1 AKA11355.1 deaD_2 deaD_2 pnp_3 pnp_3 ushA ushA AKA11414.1 AKA11414.1 mazG_1 mazG_1 mazG_2 mazG_2 cpdB cpdB kamA_1 kamA_1 AKA11559.1 AKA11559.1 xseA xseA rnhA_2 rnhA_2 pgpB pgpB ycbX ycbX xseB xseB glgX glgX gloB gloB murQ_2 murQ_2 anmK_2 anmK_2 cof cof grcA grcA AKA11930.1 AKA11930.1 AKA12029.1 AKA12029.1 AKA12197.1 AKA12197.1 nudC nudC nagB nagB AKA12261.1 AKA12261.1 rph rph AKA12294.1 AKA12294.1 AKA12358.1 AKA12358.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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aldAAldehyde dehydrogenase; NAD-linked; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (480 aa)
coaBCBifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (151 aa)
putAProline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1199 aa)
AKA12503.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
iolD_23D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (644 aa)
iolEInosose dehydratase; Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol). Belongs to the IolE/MocC family. (298 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
iolB5-deoxyglucuronate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
gabDSuccinate-semialdehyde dehydrogenase; Catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
AKA12576.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0597 family. (433 aa)
kynBCyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
garR_2Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
mltCMurein transglycosylase; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (363 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (503 aa)
nanEN-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (229 aa)
nanKN-acetylmannosamine kinase; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. (300 aa)
nanAN-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (292 aa)
dlgD_12,3-diketo-L-gulonate reductase; NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH2/MDH2 oxidoreductase family. (332 aa)
glpDFAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa)
garR_13-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AKA10265.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
uxuA_2Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (394 aa)
AKA10327.12', 3'-cyclic nucleotide 2'-phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
yfkNHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (353 aa)
ulaGAscorbate 6-phosphate lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
AKA10343.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1030 aa)
mtnN_15'-methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa)
slyXSlyX; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SlyX family. (73 aa)
pdxTGlutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (190 aa)
pemKPemk protein; Toxic component of a type II toxin-antitoxin (TA) system. (110 aa)
rppHRNA pyrophosphohydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (214 aa)
AKA10436.1S-formylglutathione hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
AKA10445.1NAD(P)H nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
katA_3Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)
yafQAddiction module antitoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (89 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. (144 aa)
AKA10487.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
surEStationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (262 aa)
gnd6-phosphogluconate dehydrogenase; Catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
mltFMurein transglycosylase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (497 aa)
rutBIsochorismatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
rneRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (977 aa)
AKA10654.1Purine nucleoside phosphoramidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (198 aa)
AKA10706.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0267 family. (103 aa)
hpaC4-hydroxyphenylacetate 3-monooxygenase; Catalyzes the reduction of MN, FAD and riboflavin by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
malSAlpha-amylase; Periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; Derived by automated computational analysis using gene prediction method: Protein Homology. (685 aa)
AKA10789.1PTS mannose transporter subunit IID; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
atzCHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
gloAGlyoxalase I; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (135 aa)
AKA10830.1Phosphatidylglycerophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
rdxANitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (258 aa)
deoDPurine nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
AKA10897.1NADH-dependent flavin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
cdd_1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
yafQ_2Toxin RelE; Derived by automated computational analysis using gene prediction method: Protein Homology. (89 aa)
AKA12712.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
rhlB_1RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
AKA11127.1Lysozyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
AKA11156.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
AKA11202.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
AKA11225.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
sucB_2Dihydrolipoamide succinyltransferase; Component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
yhaXHAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
AKA11263.1Nucleoside-triphosphate diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
AKA11284.1Lysozyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
rnb_2Exoribonuclease II; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. (658 aa)
csrACarbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa)
AKA11355.1NAD(P)H nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
deaD_2DEAD/DEAH box helicase; Participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; Derived by automated computational analysis using gene prediction method: Protein Homology. (602 aa)
pnp_3Polynucleotide phosphorylase/polyadenylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (716 aa)
ushA5'-nucleotidase; Catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
AKA11414.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
mazG_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
mazG_2Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (42 aa)
cpdBPeriplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (658 aa)
kamA_1Lysine 2,3-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
AKA11559.1VanZ family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (511 aa)
rnhA_2Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (153 aa)
pgpBPhosphatidylglycerophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
ycbXFe-S protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (76 aa)
glgXGlycogen debranching protein; Catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 13 family. (670 aa)
gloBHydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (235 aa)
murQ_2N-acetylmuramic acid-6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (291 aa)
anmK_2anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (377 aa)
cofMembrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
grcAAutonomous glycyl radical cofactor GrcA; Acts as a radical domain for damaged PFL and possibly other radical proteins. (127 aa)
AKA11930.1Deoxyguanosinetriphosphate triphosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
AKA12029.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
AKA12197.1Cytotoxic translational repressor of toxin-antitoxin stability system; Derived by automated computational analysis using gene prediction method: Protein Homology. (83 aa)
nudCNADH pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. NudC subfamily. (253 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
AKA12261.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa)
AKA12294.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
AKA12358.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (99 aa)
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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