STRINGSTRING
topB_5 topB_5 dnaB_3 dnaB_3 topA_1 topA_1 parC_2 parC_2 mukB mukB AKA12772.1 AKA12772.1 mukE mukE mukF mukF AKA11177.1 AKA11177.1 AKA10552.1 AKA10552.1 AKA10492.1 AKA10492.1 recG_1 recG_1 AKA11140.1 AKA11140.1 AKA11134.1 AKA11134.1 AKA11125.1 AKA11125.1 AKA11103.1 AKA11103.1 AKA11099.1 AKA11099.1 AKA11098.1 AKA11098.1 AKA11095.1 AKA11095.1 AKA11093.1 AKA11093.1 gyrB gyrB AKA11064.1 AKA11064.1 parE_3 parE_3 priA_2 priA_2 recD_3 recD_3 ruvA ruvA ruvB ruvB rep rep topA_2 topA_2 uvrD uvrD hupA hupA helD_1 helD_1 AKA12414.1 AKA12414.1 mfd_2 mfd_2 gyrA gyrA recQ recQ rapA_4 rapA_4 recB_5 recB_5 topB_2 topB_2 dnaB_1 dnaB_1 AKA11581.1 AKA11581.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
topB_5DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (683 aa)
dnaB_3DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (487 aa)
topA_1DNA topoisomerase I; Catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; Derived by automated computational analysis using gene prediction method: Protein Homology. (868 aa)
parC_2DNA topoisomerase IV subunit A; Decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; Derived by automated computational analysis using gene prediction method: Protein Homology. (748 aa)
mukBCell division protein MukB; SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; Derived by automated computational analysis using gene prediction method: Protein Homology. (1486 aa)
AKA12772.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
mukECondesin subunit E; Acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
mukFCondesin subunit F; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. (447 aa)
AKA11177.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
AKA10552.1Terminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
AKA10492.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Dps family. (168 aa)
recG_1ATP-dependent DNA helicase RecG; Catalyzes branch migration in Holliday junction intermediates; Derived by automated computational analysis using gene prediction method: Protein Homology. (693 aa)
AKA11140.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
AKA11134.1DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
AKA11125.1Bacteriophage terminase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
AKA11103.1Host specificity protein J; Derived by automated computational analysis using gene prediction method: Protein Homology. (2349 aa)
AKA11099.1CRISPR-associated protein Cas2; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
AKA11098.1CRISPR-associated protein Cas1; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
AKA11095.1CRISPR-associated protein Csd2; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
AKA11093.1CRISPR-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
gyrBDNA gyrase subunit B; Negatively supercoils closed circular double-stranded DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (810 aa)
AKA11064.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (496 aa)
parE_3DNA topoisomerase IV subunit B; Decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; Derived by automated computational analysis using gene prediction method: Protein Homology. (635 aa)
priA_2Primosomal protein N; Derived by automated computational analysis using gene prediction method: Protein Homology. (732 aa)
recD_3Exodeoxyribonuclease V subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (653 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
repATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (672 aa)
topA_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
uvrDDNA-dependent helicase II; Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair; Derived by automated computational analysis using gene prediction method: Protein Homology. (732 aa)
hupADNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
helD_1Derived by automated computational analysis using gene prediction method: Protein Homology. (926 aa)
AKA12414.1Exodeoxyribonuclease V subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. (1096 aa)
mfd_2Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1177 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (898 aa)
recQATP-dependent DNA helicase RecQ; Functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (599 aa)
rapA_4ATP-dependent helicase; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (970 aa)
recB_5Exodeoxyribonuclease V subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (1174 aa)
topB_2DNA topoisomerase III; Decatenates replicating daughter chromosomes; Derived by automated computational analysis using gene prediction method: Protein Homology. (639 aa)
dnaB_1DNA helicase; Unwinds double stranded DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
AKA11581.1Primosomal replication protein N; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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