STRINGSTRING
AKA10280.1 AKA10280.1 dppF dppF dppD dppD ccmA_1 ccmA_1 tcyC tcyC recA recA lolD lolD hmuV_4 hmuV_4 gsiA_7 gsiA_7 potA potA ftsY ftsY ftsE ftsE lptB_2 lptB_2 malK_2 malK_2 ruvB ruvB gsiA_13 gsiA_13 AKA11036.1 AKA11036.1 malK_1 malK_1 cydD cydD AKA11080.1 AKA11080.1 znuC znuC gsiA_11 gsiA_11 pstB pstB macB_3 macB_3 araG araG dnaB_3 dnaB_3 hflB hflB msbA_2 msbA_2 metN2 metN2 uvrA_1 uvrA_1 radA radA gsiA_10 gsiA_10 oppD oppD gsiA_3 gsiA_3 der der AKA11892.1 AKA11892.1 lon lon metN metN AKA12015.1 AKA12015.1 cysA cysA metN_1 metN_1 dnaX_1 dnaX_1 ettA ettA hmuV_2 hmuV_2 fhuC_2 fhuC_2 AKA12175.1 AKA12175.1 rbsA_2 rbsA_2 gsiA_5 gsiA_5 thiQ thiQ mglA_3 mglA_3 xylG_2 xylG_2 fbpC fbpC ffh_1 ffh_1 hslU hslU lktB lktB xylG_2-2 xylG_2-2 xylG_1 xylG_1 kpsT kpsT hmuV_1 hmuV_1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKA10280.1Molybdenum ABC transporter ATP-binding protein; Contains 2 ATP-binding cassettes; involved in the transport of molybdenum; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
dppFPart of the ABC transporter complex DppABCDF involved in the transport of dipeptides; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
dppDDppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
ccmA_1Heme ABC transporter ATP-binding protein; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. (213 aa)
tcyCAmino acid ABC transporter ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (368 aa)
lolDABC transporter ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. (227 aa)
hmuV_4Hemin ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
gsiA_7Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (531 aa)
potAPutrescine/spermidine ABC transporter ATPase; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (371 aa)
ftsYCell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (498 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (217 aa)
lptB_2Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
malK_2Maltose/maltodextrin transporter ATP-binding protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. (372 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
gsiA_13Peptide ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
AKA11036.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (643 aa)
malK_1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
cydDCysteine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (588 aa)
AKA11080.1Amino acid ABC transporter permease; In Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; Derived by automated computational analysis using gene prediction method: Protein Homology. (554 aa)
znuCZinc ABC transporter ATPase; Involved in transport of zinc(II) with ZnuA and C; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
gsiA_11Peptide ABC transporter ATP-binding protein; Involved in resistance to antimibial peptides; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
pstBPhosphate ABC transporter ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (256 aa)
macB_3Macrolide transporter; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (640 aa)
araGLipase; Derived by automated computational analysis using gene prediction method: Protein Homology. (496 aa)
dnaB_3DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (487 aa)
hflBInner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AAA ATPase family. (647 aa)
msbA_2Lipid transporter ATP-binding/permease; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. (587 aa)
metN2ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
uvrA_1Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (942 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (459 aa)
gsiA_10Peptide ABC transporter ATP-binding protein; With OppABCD is involved in the transport of oligopeptides; OppF and OppD are ATP-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
oppDOligopeptide transporter ATP-binding component; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (330 aa)
gsiA_3ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
derGTP-binding protein Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (511 aa)
AKA11892.1ATP-dependent helicase HrpA; Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; Derived by automated computational analysis using gene prediction method: Protein Homology. (1328 aa)
lonDNA-binding protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (800 aa)
metNDL-methionine transporter ATP-binding subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (344 aa)
AKA12015.1ABC transporter ATPase; Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (654 aa)
cysAMolybdenum ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
metN_1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
dnaX_1DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (685 aa)
ettAABC transporter ATP-binding protein; ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; Derived by automated computational analysis using gene prediction method: Protein Homology. (556 aa)
hmuV_2Heme ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
fhuC_2ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
AKA12175.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
rbsA_2Sugar ABC transporter ATP-binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (498 aa)
gsiA_5ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (470 aa)
thiQThiamine ABC transporter ATP-binding protein; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. (216 aa)
mglA_3Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
xylG_2D-ribose transporter ATP-binding protein; With RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; Derived by automated computational analysis using gene prediction method: Protein Homology. (514 aa)
fbpCFerric transporter ATP-binding subunit; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (349 aa)
ffh_1Signal recognition particle; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
hslUATP-dependent protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (440 aa)
lktBPeptidase C39; Part of the ABC transporter complex LktBD involved in leukotoxin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable). (708 aa)
xylG_2-2Xylose transporter; Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family. (504 aa)
xylG_1Sugar ABC transporter ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
kpsTATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
hmuV_1Peptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.