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fkpA fkpA rpoB rpoB rpoC_4 rpoC_4 AKA10394.1 AKA10394.1 dppC dppC dppB dppB dppA_1 dppA_1 luxB luxB tuf tuf AKA10684.1 AKA10684.1 AKA10721.1 AKA10721.1 gsiA_7 gsiA_7 oppC_1 oppC_1 oppB oppB ybbN ybbN trxB_2 trxB_2 sodA sodA msrAB_2 msrAB_2 trxA trxA AKA10972.1 AKA10972.1 secA secA AKA11237.1 AKA11237.1 sucB_2 sucB_2 dppA_6 dppA_6 sotB_1 sotB_1 sotB_2 sotB_2 pstS_1 pstS_1 ibpA ibpA AKA11403.1 AKA11403.1 lrp_2 lrp_2 ompH ompH aceF aceF msbA_2 msbA_2 AKA11658.1 AKA11658.1 AKA11708.1 AKA11708.1 AKA11788.1 AKA11788.1 fklB_3 fklB_3 AKA11840.1 AKA11840.1 luxA_2 luxA_2 AKA11856.1 AKA11856.1 bcp bcp AKA11862.1 AKA11862.1 gsiC_1 gsiC_1 gsiD_2 gsiD_2 ribD ribD bcr bcr secE secE tpx tpx ulaG ulaG fklB_1 fklB_1 AKA10254.1 AKA10254.1 AKA12680.1 AKA12680.1 AKA12679.1 AKA12679.1 asnC asnC nikC nikC rpoZ rpoZ AKA12334.1 AKA12334.1 AKA12335.1 AKA12335.1 AKA12362.1 AKA12362.1 AKA12376.1 AKA12376.1 hxuA hxuA hbpA_4 hbpA_4 rpoA rpoA secY secY tuf-2 tuf-2 AKA12610.1 AKA12610.1 hbpA_1 hbpA_1 ndk ndk secD secD secF secF AKA12029.1 AKA12029.1 AKA12033.1 AKA12033.1 pcaK pcaK AKA12094.1 AKA12094.1 mlaD_1 mlaD_1 yhjE yhjE AKA12272.1 AKA12272.1 nikB nikB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fkpAPeptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1341 aa)
rpoC_4DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1427 aa)
AKA10394.1Porin; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
dppCPeptide transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
dppBPeptide ABC transporter permease; Transports peptides consisting of two or three amino acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
dppA_1Peptide transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (533 aa)
luxBDehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
tufElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa)
AKA10684.1Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (615 aa)
AKA10721.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
gsiA_7Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (531 aa)
oppC_1Peptide ABC transporter permease; With OppABDF is involved in the transport of oligopeptides of up to 5 amino acids into the cell; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
oppBOligopeptide transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
ybbNHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
trxB_2Thioredoxin reductase; Catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
sodASuperoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (213 aa)
msrAB_2Methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (168 aa)
trxAThioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family. (109 aa)
AKA10972.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
secAPreprotein translocase subunit SecA; Functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not es [...] (908 aa)
AKA11237.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
sucB_2Dihydrolipoamide succinyltransferase; Component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
dppA_6Peptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)
sotB_1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
sotB_2Sugar efflux transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
pstS_1Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
ibpAFilamentous hemagglutinin; Derived by automated computational analysis using gene prediction method: Protein Homology. (3214 aa)
AKA11403.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
lrp_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
ompHMembrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
aceFE2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; Derived by automated computational analysis using gene prediction method: Protein Homology. (636 aa)
msbA_2Lipid transporter ATP-binding/permease; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. (587 aa)
AKA11658.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
AKA11708.1Preprotein translocase subunit SecG; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
AKA11788.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
fklB_3Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
AKA11840.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
luxA_2Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
AKA11856.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
bcpBacterioferritin comigratory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
AKA11862.1Peptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (527 aa)
gsiC_1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
gsiD_2ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (656 aa)
ribDRiboflavin biosynthesis protein RibD; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
bcrBicyclomycin/multidrug efflux system; Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
secEPreprotein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (137 aa)
tpxPeroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (165 aa)
ulaGAscorbate 6-phosphate lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
fklB_1Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
AKA10254.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (102 aa)
AKA12680.1Transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
AKA12679.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
asnCTranscriptional repressor of asnA which codes for aspartate-ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
nikCABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (93 aa)
AKA12334.1Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
AKA12335.1Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
AKA12362.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
AKA12376.1Ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
hxuAHeme transporter CcmD; Derived by automated computational analysis using gene prediction method: Protein Homology. (938 aa)
hbpA_4Peptide transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa)
secYPreprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (439 aa)
tuf-2Elongation factor Tu; EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
AKA12610.1Alkylhydroperoxidase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (180 aa)
hbpA_1Peptide transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (138 aa)
secDPreprotein translocase subunit SecD; Part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; Derived by automated computational analysis using gene prediction method: Protein Homology. (602 aa)
secFPreprotein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (324 aa)
AKA12029.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
AKA12033.1Ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
pcaKMFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
AKA12094.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
mlaD_1Toluene ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
yhjETransporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
AKA12272.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (524 aa)
nikBABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
Your Current Organism:
Mannheimia haemolytica
NCBI taxonomy Id: 75985
Other names: ATCC 33396, CCUG 12392, CCUG 408, CIP 103426, DSM 10531, M. haemolytica, NCTC 9380, Pasteurella haemolytica, strain J.A. Watt 1266AB
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