STRINGSTRING
AEA33002.1 AEA33002.1 AEA33361.1 AEA33361.1 AEA33362.1 AEA33362.1 AEA33363.1 AEA33363.1 hslU hslU hslV hslV clpX clpX clpP clpP hrcA hrcA grpE grpE dnaK dnaK dnaJ dnaJ AEA33910.1 AEA33910.1 cysS cysS AEA34047.1 AEA34047.1 AEA34048.1 AEA34048.1 AEA34049.1 AEA34049.1 clpB clpB groS groS groL groL AEA34580.1 AEA34580.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AEA33002.1COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; IPR005881; KEGG: ddf:DEFDS_2169 serine O-acetyltransferase; PRIAM: Serine O-acetyltransferase; SPTR: Serine O-acetyltransferase; TIGRFAM: Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase. (271 aa)
AEA33361.1COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR000192; KEGG: nam:NAMH_0812 cysteine desulfurase; PFAM: Aminotransferase, class V/Cysteine desulfurase; PRIAM: Cysteine desulfurase; SPTR: Cysteine desulfurase; PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurase, NifS family, epsilon proteobacteria type. (390 aa)
AEA33362.1Nitrogen-fixing NifU domain protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. (322 aa)
AEA33363.1Transcriptional regulator, BadM/Rrf2 family; COGs: COG1959 transcriptional regulator protein; InterPro IPR000944; KEGG: cbf:CLI_2632 rrF2 family protein; PFAM: Transcription regulator Rrf2; SPTR: RrF2 family protein; TIGRFAM: Transcription regulator Rrf2; PFAM: Transcriptional regulator; TIGRFAM: rrf2 family protein (putative transcriptional regulator). (143 aa)
hslUATP-dependent hsl protease ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (450 aa)
hslVATP-dependent protease hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (179 aa)
clpXATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (418 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (205 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (336 aa)
grpEProtein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (186 aa)
dnaKChaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (638 aa)
dnaJChaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (365 aa)
AEA33910.1Heat shock protein DnaJ domain protein; COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterPro IPR001623; IPR019734; IPR001440; KEGG: ddf:DEFDS_1649 hypothetical protein; PFAM: Heat shock protein DnaJ, N-terminal; Tetratricopeptide TPR-1; SMART: Heat shock protein DnaJ, N-terminal; Tetratricopeptide repeat; SPTR: Putative uncharacterized protein; PFAM: DnaJ domain; Tetratricopeptide repeat. (204 aa)
cysSCOGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR015273; IPR015803; KEGG: tye:THEYE_A1975 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase, class Ia; Cysteinyl-tRNA synthetase, class Ia, DALR; PRIAM: Cysteine--tRNA ligase; SMART: Cysteinyl-tRNA synthetase, class Ia, DALR; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (474 aa)
AEA34047.1Transcriptional regulator, MerR family; COGs: COG0789 transcriptional regulator protein; InterPro IPR000551; KEGG: ddf:DEFDS_1926 MerR family transcriptional regulator; PFAM: HTH transcriptional regulator, MerR; SMART: HTH transcriptional regulator, MerR; SPTR: Transcriptional regulator, MerR family; PFAM: MerR family regulatory protein. (125 aa)
AEA34048.1Heat shock protein DnaJ domain protein; COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterPro IPR001623; IPR002939; KEGG: rca:Rcas_2836 chaperone DnaJ domain-containing protein; PFAM: Heat shock protein DnaJ, N-terminal; Chaperone DnaJ, C-terminal; SMART: Heat shock protein DnaJ, N-terminal; SPTR: Chaperone DnaJ domain protein; PFAM: DnaJ domain; DnaJ C terminal region. (283 aa)
AEA34049.1Heat shock protein Hsp20; COGs: COG0071 Molecular chaperone (small heat shock protein); InterPro IPR002068; KEGG: ddf:DEFDS_1928 heat shock protein Hsp20; PFAM: Heat shock protein Hsp20; SPTR: Heat shock protein Hsp20; PFAM: Hsp20/alpha crystallin family; Belongs to the small heat shock protein (HSP20) family. (147 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (868 aa)
groS10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (88 aa)
groL60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (546 aa)
AEA34580.1COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: dth:DICTH_1733 cysteine synthase A; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A. (283 aa)
Your Current Organism:
Hippea maritima
NCBI taxonomy Id: 760142
Other names: H. maritima DSM 10411, Hippea maritima DSM 10411, Hippea maritima MS2, Hippea maritima MS[subscript]2, Hippea maritima str. DSM 10411, Hippea maritima strain DSM 10411
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