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sucD sucD sucC sucC aceE aceE aceF aceF lpd lpd nagK nagK fumA fumA pdhA pdhA ebA2187 ebA2187 ebA2188 ebA2188 gabD gabD korA2 korA2 korB2 korB2 ebA3300 ebA3300 fumC fumC maeB2 maeB2 maeB1 maeB1 ebA4535 ebA4535 sdhD sdhD sdhB sdhB korA korA korB korB ldp ldp sucB sucB sucA sucA gltA gltA sdhB-2 sdhB-2 sdhA sdhA mdh mdh merA merA icd2 icd2 sdhC sdhC sdhD-2 sdhD-2 sdhC-2 sdhC-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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sucDSuccinyl-CoA synthetase, alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)
sucCSuccinyl-CoA synthetase, beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
aceEPyruvate dehydrogenase multienzyme complex, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (891 aa)
aceFPyruvate dehydrogenase multienzyme complex, dihydrolipoamide acetyltransferase component (E2); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (583 aa)
lpdPyruvate dehydrogenase multienzyme complex, Dihydrolipoamide dehydrogenase component. (615 aa)
nagKFumarylpyruvate hydrolase. (236 aa)
fumAFumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (510 aa)
pdhAPutative pyruvate dehydrogenase E1 component (alpha subunit) oxidoreductase protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (362 aa)
ebA2187Putative pyruvate decarboxylase E1 (Beta subunit) oxidoreductase protein. (326 aa)
ebA2188Putative dihydrolipoamide acetyltransferase. (367 aa)
gabDSuccinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)
korA22-oxoglutarate ferredoxin oxidoreductase alpha subunit. (636 aa)
korB22-oxoglutarate ferredoxin oxidoreductase beta subunit. (341 aa)
ebA3300Potential fumarylacetoacetate hydrolase (extradiol catechol pathway). (342 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
maeB2NADP-dependent malic enzyme. (758 aa)
maeB1NADP-dependent malic enzyme. (767 aa)
ebA4535Fragment of conserved hypothetical protein, predicted Pyridine nucleotide-disulphide oxidoreductase family. (360 aa)
sdhDSuccinate dehydrogenase,hydrophobic membrane anchor protein. (114 aa)
sdhBSuccinate dehydrogenase (Iron-sulfur subunit) oxidoreductase protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (231 aa)
korA2-ketoglutarate: NADP oxidoreductase,alpha subunit. (615 aa)
korB2-ketoglutarate: NADP oxidoreductase, beta subunit. (351 aa)
ldp2-oxoglutarate dehydrogenase complex, E3 component, Dihydrolipoamide dehydrogenase. (476 aa)
sucB2-oxoglutarate dehydrogenase complex, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (394 aa)
sucA2-oxoglutarate dehydrogenase complex, E1 component. (942 aa)
gltACitrate synthase; Belongs to the citrate synthase family. (431 aa)
sdhB-2Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (236 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (597 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
merASimilar to mercuric reductase. (511 aa)
icd2Isocitrate dehydrogenase isozyme 2,monomeric type, NADP-specific; Belongs to the monomeric-type IDH family. (745 aa)
sdhCPutative succinate dehydrogenase cytochrome B subunit (Succinate dehydrogenase, cytochrome b556 subunit. (128 aa)
sdhD-2Succinate dehydrogenase (membrane anchor subunit). (115 aa)
sdhC-2Succinate dehydrogenase cytochrome b-556 subunit (EC 1.3.99.1). (129 aa)
Your Current Organism:
Aromatoleum aromaticum
NCBI taxonomy Id: 76114
Other names: A. aromaticum EbN1, Aromatoleum aromaticum EbN1, Aromatoleum aromaticum str. EbN1, Aromatoleum aromaticum strain EbN1, Azoarcus sp. EbN1
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