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fadA fadA c2A172 c2A172 pykA pykA ppc ppc acsA acsA aceE aceE aceF aceF lpd lpd accB accB accC accC poxB poxB acsA-2 acsA-2 fumA fumA pdhA pdhA ebA2187 ebA2187 ebA2188 ebA2188 ebA2194 ebA2194 dhaL dhaL pta pta ackA ackA ebA2717 ebA2717 xccA xccA ppsB ppsB ppsA ppsA korA2 korA2 korB2 korB2 xccC xccC ebA3639 ebA3639 fumC fumC ebA3749 ebA3749 dldH dldH ppcK ppcK maeB2 maeB2 accA accA maeB1 maeB1 korA korA korB korB betB betB aldB aldB ebA4717 ebA4717 accD accD ackA-2 ackA-2 ebA5202 ebA5202 ebA5319 ebA5319 ferA ferA ferA-2 ferA-2 ebA5673 ebA5673 xccB xccB xccC-2 xccC-2 ppsA-2 ppsA-2 ppsB-2 ppsB-2 pps pps ebA6190 ebA6190 gloB gloB ldp ldp mdh mdh leuA leuA glcB glcB gloA gloA xccB-2 xccB-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fadABeta-subunit of fatty acid oxidation complex, 3-keto-acyl-CoA-thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa)
c2A172beta-Ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
pykAPyruvate kinase II protein; Belongs to the pyruvate kinase family. (482 aa)
ppcPutative phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (990 aa)
acsAPutative acetyl-coenzyme A synthetase. (563 aa)
aceEPyruvate dehydrogenase multienzyme complex, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (891 aa)
aceFPyruvate dehydrogenase multienzyme complex, dihydrolipoamide acetyltransferase component (E2); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (583 aa)
lpdPyruvate dehydrogenase multienzyme complex, Dihydrolipoamide dehydrogenase component. (615 aa)
accBAcetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (150 aa)
accCPutative biotin carboxylase protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa)
poxBPyruvate oxidase; Belongs to the TPP enzyme family. (598 aa)
acsA-2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (662 aa)
fumAFumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (510 aa)
pdhAPutative pyruvate dehydrogenase E1 component (alpha subunit) oxidoreductase protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (362 aa)
ebA2187Putative pyruvate decarboxylase E1 (Beta subunit) oxidoreductase protein. (326 aa)
ebA2188Putative dihydrolipoamide acetyltransferase. (367 aa)
ebA2194Predicted Acetyl-CoA synthetase. (727 aa)
dhaLAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (506 aa)
ptaPutative phosphate acetyltransferase (EC 2.3.1.8), gene: PTA OR RPA4567. (470 aa)
ackAPutative acetate kinase (EC 2.7.2.1),gene: ACKA OR RPA4566; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
ebA2717Putative metallo-beta-lactamase family protein. (213 aa)
xccAPutative carboxylase subunit of acetyl-CoA carboxylase-like enzyme. (495 aa)
ppsBPhenylphosphate synthase beta subunit. (374 aa)
ppsAPhenylphosphate synthase alpha subunit. (612 aa)
korA22-oxoglutarate ferredoxin oxidoreductase alpha subunit. (636 aa)
korB22-oxoglutarate ferredoxin oxidoreductase beta subunit. (341 aa)
xccCBiotin carboxylase subunit of acetyl-CoA carboxylase-like enzyme. (460 aa)
ebA3639Putative acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
ebA3749Conserved hypothetical protein. (158 aa)
dldHD-lactate dehydrogenase (acceptor: cytochrome). (469 aa)
ppcKPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (614 aa)
maeB2NADP-dependent malic enzyme. (758 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (380 aa)
maeB1NADP-dependent malic enzyme. (767 aa)
korA2-ketoglutarate: NADP oxidoreductase,alpha subunit. (615 aa)
korB2-ketoglutarate: NADP oxidoreductase, beta subunit. (351 aa)
betBPutative betaine aldehyde dehydrogenase (BADH) oxidoreductase protein; Belongs to the aldehyde dehydrogenase family. (475 aa)
aldBPutative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (504 aa)
ebA4717Acyl-CoA synthetase. (663 aa)
accDPutative acetyl-coenzyme A carboxylase carboxyl transferase (Subunit beta) protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa)
ackA-2Similar to acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (774 aa)
ebA5202Putative thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
ebA5319Putative beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa)
ferAOrganic acid-CoA ligase (ADP forming),similar to feruloyl-CoA synthetase. (712 aa)
ferA-2Organic acid-CoA ligase (ADP forming) similar to feruloyl-CoA synthetase. (716 aa)
ebA5673Predicted Acetyl-CoA acetyltransferase (thiolase). (387 aa)
xccBBiotin carboxyl carrier subunit of acetyl-CoA carboxylase-like protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa)
xccC-2Biotin carboxylase subunit of unknown acetyl-CoA carboxylase-like enzyme. (451 aa)
ppsA-2Similar to subunit A of phenylphosphate synthetase and phosphoenolpyruvate synthase. (592 aa)
ppsB-2Similar to subunit B of phenylphosphate synthetase or phosphoenolpyruvate synthase. (348 aa)
ppsPhosphoenolpyruvate synthetase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (788 aa)
ebA6190Putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (501 aa)
gloBZn-dependent hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (263 aa)
ldp2-oxoglutarate dehydrogenase complex, E3 component, Dihydrolipoamide dehydrogenase. (476 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (511 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
gloALactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (127 aa)
xccB-2Biotin carboxyl carrier protein of unknown carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (163 aa)
Your Current Organism:
Aromatoleum aromaticum
NCBI taxonomy Id: 76114
Other names: A. aromaticum EbN1, Aromatoleum aromaticum EbN1, Aromatoleum aromaticum str. EbN1, Aromatoleum aromaticum strain EbN1, Azoarcus sp. EbN1
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