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| | fadB | Alpha-subunit of fatty acid oxidation complex. (678 aa) |
| | fadA | Beta-subunit of fatty acid oxidation complex, 3-keto-acyl-CoA-thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa) |
| | c2A172 | beta-Ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa) |
| | c2A173 | 3-Hydroxyacyl-CoA dehydrogenase. (506 aa) |
| | gpmB | Phosphoglycerate mutase 2; Belongs to the phosphoglycerate mutase family. (216 aa) |
| | glyA | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (249 aa) |
| | rpiA | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (220 aa) |
| | prk | Phosphoribulokinase. (291 aa) |
| | tktA | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (677 aa) |
| | gapA | Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa) |
| | pykA | Pyruvate kinase II protein; Belongs to the pyruvate kinase family. (482 aa) |
| | fbaA | Fructose-bisphosphate aldolase protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | ppc | Putative phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (990 aa) |
| | folD | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (312 aa) |
| | fbp | Fructose-1,6-bisphosphatase. (333 aa) |
| | acsA | Putative acetyl-coenzyme A synthetase. (563 aa) |
| | sucD | Succinyl-CoA synthetase, alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa) |
| | sucC | Succinyl-CoA synthetase, beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | aceE | Pyruvate dehydrogenase multienzyme complex, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (891 aa) |
| | aceF | Pyruvate dehydrogenase multienzyme complex, dihydrolipoamide acetyltransferase component (E2); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (583 aa) |
| | lpd | Pyruvate dehydrogenase multienzyme complex, Dihydrolipoamide dehydrogenase component. (615 aa) |
| | prs | Phosphoribosyl transferase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | accB | Acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (150 aa) |
| | accC | Putative biotin carboxylase protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa) |
| | acsA-2 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (662 aa) |
| | fumA | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (510 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase oxidoreductase protein; Belongs to the methylenetetrahydrofolate reductase family. (277 aa) |
| | ebA2038 | Fusion of 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase. (671 aa) |
| | sbmA | Methylmalonyl-CoA mutase subunit alpha. (537 aa) |
| | katA | Catalase; Belongs to the catalase family. (480 aa) |
| | pdhA | Putative pyruvate dehydrogenase E1 component (alpha subunit) oxidoreductase protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (362 aa) |
| | ebA2187 | Putative pyruvate decarboxylase E1 (Beta subunit) oxidoreductase protein. (326 aa) |
| | ebA2188 | Putative dihydrolipoamide acetyltransferase. (367 aa) |
| | pta | Putative phosphate acetyltransferase (EC 2.3.1.8), gene: PTA OR RPA4567. (470 aa) |
| | ackA | Putative acetate kinase (EC 2.7.2.1),gene: ACKA OR RPA4566; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa) |
| | ebA2315 | Fusion of 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase. (797 aa) |
| | fdhA | Formate dehydrogenase alpha subunit,molybdenum or tungsten enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (950 aa) |
| | fdhB | Formate dehydrogenase, NAD(P) reducing, beta subunit. (585 aa) |
| | fdhC | Putative Formate dehydrogenase subunit C. (375 aa) |
| | fdhB-2 | Formate dehydrogenase iron-sulfur subunit. (201 aa) |
| | fdhA-2 | Formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (968 aa) |
| | ppsB | Phenylphosphate synthase beta subunit. (374 aa) |
| | ppsA | Phenylphosphate synthase alpha subunit. (612 aa) |
| | korA2 | 2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (636 aa) |
| | korB2 | 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (341 aa) |
| | xccC | Biotin carboxylase subunit of acetyl-CoA carboxylase-like enzyme. (460 aa) |
| | ebA3224 | Putative ribose-phosphate pyrophosphokinase. (313 aa) |
| | ilvA-2 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (506 aa) |
| | ilvA | Putative threonine dehydratase. (413 aa) |
| | thrH | Homoserine kinase. (203 aa) |
| | paaH | 3-Hydroxyacyl-CoA dehydrogenase PaaH involved in aerobic phenylacetate metabolism. (509 aa) |
| | ebA3639 | Putative acyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa) |
| | ebA3640 | Putative acyl CoA dehydrogenase oxidoreductase protein. (377 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa) |
| | sbmB | Methylmalonyl-CoA mutase, beta subunit. (722 aa) |
| | pccB | Propionyl-CoA carboxylase beta subunit. (510 aa) |
| | pccA | Propionyl-CoA carboxylase, alpha subunit. (666 aa) |
| | maeB2 | NADP-dependent malic enzyme. (758 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (380 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (231 aa) |
| | maeB1 | NADP-dependent malic enzyme. (767 aa) |
| | ebA4434 | Putative maoC-like dehydratase. (149 aa) |
| | aceA | Isocitrate lyase. (433 aa) |
| | sdhD | Succinate dehydrogenase,hydrophobic membrane anchor protein. (114 aa) |
| | sdhB | Succinate dehydrogenase (Iron-sulfur subunit) oxidoreductase protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (231 aa) |
| | korA | 2-ketoglutarate: NADP oxidoreductase,alpha subunit. (615 aa) |
| | korB | 2-ketoglutarate: NADP oxidoreductase, beta subunit. (351 aa) |
| | hfr | Hydroxypyruvate reductase. (424 aa) |
| | talA | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (359 aa) |
| | cysK | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (325 aa) |
| | ebA4717 | Acyl-CoA synthetase. (663 aa) |
| | phbB | Acetoacetyl-CoA reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa) |
| | adh-2 | Short-chain dehydrogenase/reductase,possibly involved in polyhydroxybutyrate (PHB) synthesis; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa) |
| | hbdA | 3-hydroxybutyryl-CoA dehydrogenase. (283 aa) |
| | accD | Putative acetyl-coenzyme A carboxylase carboxyl transferase (Subunit beta) protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (271 aa) |
| | ackA-2 | Similar to acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (774 aa) |
| | ebA5004 | Iron-sulfur cluster-binding protein; potential subunit of aldehyde oxidoreductase. (158 aa) |
| | ebA5005 | Aldehyde:ferredoxin oxidoreductase,tungsten-containing. (616 aa) |
| | pfkA | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (418 aa) |
| | ebA5202 | Putative thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | pgi | Glucose-6-phosphate isomerase. (559 aa) |
| | acnA | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa) |
| | acnB | Aconitase; Belongs to the aconitase/IPM isomerase family. (869 aa) |
| | ebA5319 | Putative beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa) |
| | ebA5355 | Putative tungsten-containing aldehyde ferredoxin oxidoreductase (AOR-1). (774 aa) |
| | ebA5620 | 3-hydroxyacyl-CoA dehydrogenase. (443 aa) |
| | ebA5673 | Predicted Acetyl-CoA acetyltransferase (thiolase). (387 aa) |
| | ebA5712 | Putative esterase/lipase/thioesterase; Serine hydrolase involved in the detoxification of formaldehyde. (281 aa) |
| | fdhG | Putative formaldehyde dehydrogenase (Glutathione-dependent); Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (371 aa) |
| | xccB | Biotin carboxyl carrier subunit of acetyl-CoA carboxylase-like protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa) |
| | xccC-2 | Biotin carboxylase subunit of unknown acetyl-CoA carboxylase-like enzyme. (451 aa) |
| | ppsA-2 | Similar to subunit A of phenylphosphate synthetase and phosphoenolpyruvate synthase. (592 aa) |
| | ppsB-2 | Similar to subunit B of phenylphosphate synthetase or phosphoenolpyruvate synthase. (348 aa) |
| | pps | Phosphoenolpyruvate synthetase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (788 aa) |
| | glk | Glucokinase; Belongs to the bacterial glucokinase family. (331 aa) |
| | serB | Phosphoserine phosphatase protein. (276 aa) |
| | gcvP1 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (972 aa) |
| | gcvT | Aminomethyltransferase of Glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. (360 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | cysE | O-acetylserine synthase. (255 aa) |
| | ldp | 2-oxoglutarate dehydrogenase complex, E3 component, Dihydrolipoamide dehydrogenase. (476 aa) |
| | sucB | 2-oxoglutarate dehydrogenase complex, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (394 aa) |
| | sucA | 2-oxoglutarate dehydrogenase complex, E1 component. (942 aa) |
| | gltA | Citrate synthase; Belongs to the citrate synthase family. (431 aa) |
| | sdhB-2 | Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (236 aa) |
| | sdhA | Succinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (597 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa) |
| | acnA2 | Aconitase. (937 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa) |
| | ebA720 | Enoyl-CoA hydratase. (253 aa) |
| | glcB | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa) |
| | icd | Isocitrate dehydrogenase. (414 aa) |
| | icd2 | Isocitrate dehydrogenase isozyme 2,monomeric type, NADP-specific; Belongs to the monomeric-type IDH family. (745 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (366 aa) |
| | sdhC | Putative succinate dehydrogenase cytochrome B subunit (Succinate dehydrogenase, cytochrome b556 subunit. (128 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | sdhD-2 | Succinate dehydrogenase (membrane anchor subunit). (115 aa) |
| | xccB-2 | Biotin carboxyl carrier protein of unknown carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (163 aa) |
| | sdhC-2 | Succinate dehydrogenase cytochrome b-556 subunit (EC 1.3.99.1). (129 aa) |
| | SbmB | Methylmalonyl-CoA mutase, C-terminal domain/subunit (Cobalamin-binding). (139 aa) |
