STRINGSTRING
mutS mutS ALO47926.1 ALO47926.1 ALO49791.1 ALO49791.1 ruvA ruvA ALO49808.1 ALO49808.1 ALO49812.1 ALO49812.1 ALO48143.1 ALO48143.1 ALO48161.1 ALO48161.1 ALO48180.1 ALO48180.1 dnaX dnaX ALO48460.1 ALO48460.1 uvrB uvrB ALO48501.1 ALO48501.1 ALO48502.1 ALO48502.1 ALO48584.1 ALO48584.1 ALO48623.1 ALO48623.1 ALO48624.1 ALO48624.1 dnaG dnaG ALO48762.1 ALO48762.1 ALO48763.1 ALO48763.1 ALO48764.1 ALO48764.1 ALO49900.1 ALO49900.1 dnaA dnaA ALO48788.1 ALO48788.1 ruvC ruvC ligA ligA ALO48967.1 ALO48967.1 ALO49016.1 ALO49016.1 ALO49118.1 ALO49118.1 ALO49124.1 ALO49124.1 ALO49125.1 ALO49125.1 radA radA dinB dinB ALO49214.1 ALO49214.1 recA recA mutL mutL recG recG ALO49456.1 ALO49456.1 ALO49998.1 ALO49998.1 polA polA uvrC uvrC ruvB ruvB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (871 aa)
ALO47926.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1235 aa)
ALO49791.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (204 aa)
ALO49808.1ABC-ATPase UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (948 aa)
ALO49812.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (898 aa)
ALO48143.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (792 aa)
ALO48161.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (615 aa)
ALO48180.1DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (688 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (594 aa)
ALO48460.1DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (685 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (675 aa)
ALO48501.1Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (636 aa)
ALO48502.1single-stranded-DNA-specific exonuclease RecJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (585 aa)
ALO48584.1DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (694 aa)
ALO48623.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
ALO48624.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (374 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (660 aa)
ALO48762.1Nuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (957 aa)
ALO48763.1DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. (1079 aa)
ALO48764.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (678 aa)
ALO49900.1RNA polymerase subunit sigma; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (290 aa)
dnaAChromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (469 aa)
ALO48788.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (503 aa)
ruvCHolliday junction resolvase; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (206 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (667 aa)
ALO48967.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
ALO49016.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
ALO49118.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
ALO49124.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
ALO49125.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (67 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (472 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (362 aa)
ALO49214.1ABC-ATPase UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (939 aa)
recADNA recombination/repair protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (339 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (608 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (690 aa)
ALO49456.1Thiamine biosynthesis protein ThiJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
ALO49998.1RecX family transcriptional regulator; Modulates RecA activity; Belongs to the RecX family. (155 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (920 aa)
uvrCD-tyrosyl-tRNA(Tyr) deacylase; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (620 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (345 aa)
Your Current Organism:
Prevotella enoeca
NCBI taxonomy Id: 76123
Other names: ATCC 51261, CIP 104472, JCM 12259, NCTC 13068, P. enoeca, VPI D194A-25A
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