STRINGSTRING
dut dut ALO47741.1 ALO47741.1 ALO47742.1 ALO47742.1 ALO47787.1 ALO47787.1 ALO47834.1 ALO47834.1 ALO49768.1 ALO49768.1 pyrH pyrH tdk tdk ALO47958.1 ALO47958.1 surE surE ALO48019.1 ALO48019.1 ALO48031.1 ALO48031.1 ALO48051.1 ALO48051.1 ALO48097.1 ALO48097.1 purA purA purD purD purN purN ALO48407.1 ALO48407.1 ALO49852.1 ALO49852.1 ALO48418.1 ALO48418.1 carA carA ALO48420.1 ALO48420.1 ALO48436.1 ALO48436.1 ALO48476.1 ALO48476.1 ALO48477.1 ALO48477.1 ALO48478.1 ALO48478.1 guaA guaA ALO48554.1 ALO48554.1 ALO49869.1 ALO49869.1 purC purC ALO48643.1 ALO48643.1 ALO48766.1 ALO48766.1 ALO49903.1 ALO49903.1 glyA glyA pyrI pyrI pyrB pyrB ALO49907.1 ALO49907.1 pyrD pyrD pyrK pyrK nadE nadE ALO49173.1 ALO49173.1 xpt xpt ALO49202.1 ALO49202.1 ALO49206.1 ALO49206.1 ALO49207.1 ALO49207.1 folD folD ALO49376.1 ALO49376.1 guaB guaB purL purL ppnK ppnK gmk gmk nadD nadD purE purE ALO49564.1 ALO49564.1 pyrE pyrE fhs fhs apt apt ALO49725.1 ALO49725.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
ALO47741.1NAD-dependent deacylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
ALO47742.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
ALO47787.1Formiminotransferase-cyclodeaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)
ALO47834.1Pyrazinamidase/nicotinamidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
ALO49768.1Guanine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
ALO47958.1IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
surEStationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa)
ALO48019.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa)
ALO48031.1Purine nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
ALO48051.1Phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
ALO48097.1Competence protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. (168 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (424 aa)
purDPhosphoribosylamine--glycine ligase; Catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (422 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (189 aa)
ALO48407.1Uracil transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
ALO49852.1Thiamine biosynthesis protein ThiF; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
ALO48418.1Amidophosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (631 aa)
carACarbamoyl-phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (358 aa)
ALO48420.1Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1075 aa)
ALO48436.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
ALO48476.1Guanine permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
ALO48477.1NADH pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
ALO48478.1Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (587 aa)
guaAGMP synthetase; Catalyzes the synthesis of GMP from XMP. (514 aa)
ALO48554.1Orotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
ALO49869.1Phosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
ALO48643.1CMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
ALO48766.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (159 aa)
ALO49903.12-polyprenylphenol hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (783 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (151 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (315 aa)
ALO49907.1Dihydroorotase; Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate. (303 aa)
pyrKDiguanylate cyclase; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (258 aa)
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (655 aa)
ALO49173.1Xanthine permease XanP; High-affinity transporter for xanthine; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (188 aa)
ALO49202.15-aminoimidazole-4-carboxamide ribonucleotide transformylase; Catalyzes the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
ALO49206.1Metallophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
ALO49207.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa)
ALO49376.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (448 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (494 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1240 aa)
ppnKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
nadDNicotinate-nicotinamide nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (190 aa)
purEPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa)
ALO49564.1Uracil phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa)
fhsFormate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. (555 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
ALO49725.1Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (406 aa)
Your Current Organism:
Prevotella enoeca
NCBI taxonomy Id: 76123
Other names: ATCC 51261, CIP 104472, JCM 12259, NCTC 13068, P. enoeca, VPI D194A-25A
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